Atoltivimab

A4DAB028 | Phase-I

Target Zaire Ebolavirus Glycoprotein

Isotype / Subclass G1 / None

Company

Regeneron Pharmaceuticals

Clinical Status Phase-I

Format Whole mAb

Synonyms

REGN 3470 REGN3470 REGN-3470 INMAZEB (combination with Maftivimab and Odesivimab)

pH Formulation —

IMGT PubChem (381609025) PubChem (404720559) PubChem (472407746) PubChem (505057018) PubChem (505556050) PubChem (508534649) PubChem (513906962) Thera-SAbDab YAbS

Avg A4D Score

-0.5636

Score Range

-0.6 to -0.52

Structures

2

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB028_7tn9_G_H	7tn9	100%	-0.6035	6.5	4.0	-0.4341	-0.6454
A4DAB028_7tn9_I_J	7tn9	100%	-0.5238	6.5	4.0	-0.4105	-0.5553

Atoltivimab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2