Bentracimab

A4DAB040 | Cardiovascular / hemostasis disorders | Phase-III

Target AR-C124910XX

Isotype / Subclass G1 / None

Company

MedImmune AstraZeneca PhaseBio

Clinical Status Phase-III

Format Whole mAb

Synonyms

MEDI-2452 MEDI2452 PB-2452 PB2452

pH Formulation —

IMGT PubChem (404914104) PubChem (440234812) PubChem (472420255) PubChem (476262799) PubChem (476269467) PubChem (505557009) PubChem (507750309) PubChem (521253748) Thera-SAbDab YAbS

Avg A4D Score

-0.6296

Score Range

-0.66 to -0.6

Structures

2

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB040_5alb_H_L	5alb	100%	-0.6575	6.5	9.0	-0.2849	-0.7167
A4DAB040_5alc_H_L	5alc	96%	-0.6016	6.5	9.0	-0.1686	-0.7143

Bentracimab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2