Bezlotoxumab

A4DAB046 | Infectious diseases | Approved

Target Clostridium difficile Toxin A

Isotype / Subclass G1 / IgG1

Company

Medarex University of Massachusetts Medical School Merck & Co Merck Sharp & Dohme

Clinical Status Approved

Format Whole mAb

Synonyms

CDB1 CDB-1 MBL-CDB1 MBLCDB1 MDX 1388 MDX1388 MDX-1388 MK 6072 MK6072 MK-6072 Zinplava

pH Formulation 6

IMGT PubChem (160671640) PubChem (347911429) PubChem (377483929) PubChem (472213863) PubChem (472405119) PubChem (480403086) PubChem (481101543) PubChem (481985734) PubChem (496703304) Thera-SAbDab YAbS

Avg A4D Score

-0.7328

Score Range

-0.74 to -0.72

Structures

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB046_4np4_I_M	4np4	100%	-0.7443	6.5	9.0	-0.41	-0.7849
A4DAB046_4np4_H_L	4np4	100%	-0.7213	6.5	4.0	-0.4278	-0.7576

Bezlotoxumab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2