Bimekizumab

A4DAB048 | Immune-mediated / inflammatory disorders | Approved

Target IL17A

Isotype / Subclass G1 / IgG1

Company

UCB

Clinical Status Approved

Format Whole mAb

Synonyms

Bimzelx CDP-4940 CDP4940 UCB-4940 UCB4940

pH Formulation 5.1

IMGT PubChem (328083513) PubChem (347911408) PubChem (381127331) PubChem (404719817) PubChem (472405709) PubChem (474488722) PubChem (474489058) PubChem (475546941) PubChem (498152918) PubChem (505564081) Thera-SAbDab YAbS

Avg A4D Score

-0.754

Score Range

-0.76 to -0.75

Structures

2

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB048_8ruu_B_C	8ruu	100%	-0.7563	6.5	4.0	-0.8047	-0.7497
A4DAB048_8ruu_H_L	8ruu	100%	-0.7518	6.5	4.0	-0.6992	-0.759

Bimekizumab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2