Bleselumab

A4DAB050 | Phase-II

Target TNFRSF5/CD40

Isotype / Subclass G4 / None

Company

Kirin Brewery Astellas Pharma Kyowa Hakko Kirin

Clinical Status Phase-II

Format Whole mAb

Synonyms

ASKP 1240 ASKP1240 ASKP-1240

pH Formulation —

IMGT PubChem (374364072) PubChem (381127499) PubChem (404772686) PubChem (472408007) PubChem (474488703) PubChem (474489038) PubChem (505565379) Thera-SAbDab YAbS

Avg A4D Score

-0.6452

Score Range

-0.66 to -0.63

Structures

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB050_8yx1_A_B	8yx1	100%	-0.6331	6.0	9.0	-0.2788	-0.6769
A4DAB050_8yx1_H_L	8yx1	100%	-0.6574	6.0	9.0	-0.2925	-0.7025

Bleselumab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2