Briakinumab

A4DAB055 | Immune-mediated / inflammatory disorders | Preregistration (w)
IL12B/CLMFp40
G1 / IgG1
Cambridge Antibody Technology Abbott GmbH & Co. KG
Preregistration (w)
Whole mAb
A-796874.0 ABT-874 ABT874 BSF 415977 BSF-415977 BSF415977 J 695 J695 J-695 LU 415977 LU-415977 LU415977 Ozespa WAY-165772 WAY165772
—
IMGT PubChem (135292757) PubChem (160687953) PubChem (315661289) PubChem (347910151) PubChem (472220729) PubChem (472398910) PubChem (476262816) PubChem (476269484) PubChem (488233834) PubChem (498138517) PubChem (505565957) Thera-SAbDab YAbS
Avg A4D Score
-0.6908
Score Range
-0.72 to -0.66
Structures
12
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB055_5n2k_D_C 5n2k 100% -0.7199 6.5 9.0 -0.5906 -0.7355
A4DAB055_5n2k_L_K 5n2k 100% -0.7008 6.5 9.0 -0.5851 -0.7153
A4DAB055_5n2k_B_A 5n2k 100% -0.7058 6.5 9.0 -0.5817 -0.7212
A4DAB055_5njd_T_S 5njd 100% -0.7068 6.0 9.0 -0.6293 -0.7166
A4DAB055_5n2k_N_M 5n2k 100% -0.6862 6.5 9.0 -0.5755 -0.7002
A4DAB055_5njd_P_O 5njd 100% -0.7042 6.0 9.0 -0.6293 -0.7136
A4DAB055_5njd_N_M 5njd 100% -0.6598 6.0 9.0 -0.6008 -0.6672
A4DAB055_5njd_V_U 5njd 100% -0.6857 6.5 9.0 -0.5616 -0.7014
A4DAB055_5n2k_F_E 5n2k 100% -0.6887 6.0 9.0 -0.5595 -0.7048
A4DAB055_5njd_X_W 5njd 100% -0.6885 6.5 9.0 -0.552 -0.7057
A4DAB055_5n2k_P_O 5n2k 100% -0.6665 6.5 9.0 -0.6317 -0.671
A4DAB055_5njd_R_Q 5njd 100% -0.6767 6.5 9.0 -0.6827 -0.6759