Canakinumab

A4DAB057 | Immune-mediated / inflammatory disorders | Approved
IL1B
G1 / IgG1
Charite - Universitatsmedizin Berlin Novartis Triemli hospital University Hospital Tubingen University Hospital Zurich
Approved
Whole mAb
ACZ-885 ACZ885 Ilaris
—
IMGT PubChem (103771532) PubChem (135332926) PubChem (178103379) PubChem (329976978) PubChem (347910340) PubChem (381124992) PubChem (381124993) PubChem (440790483) PubChem (472211472) PubChem (472422543) PubChem (472437798) PubChem (472440170) PubChem (481101555) PubChem (481155460) PubChem (498124530) PubChem (519933425) Thera-SAbDab YAbS
Avg A4D Score
-0.7451
Score Range
-0.76 to -0.72
Structures
7
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB057_5bvj_H_G 5bvj 100% -0.7446 6.5 4.0 -0.3855 -0.7865
A4DAB057_4g5z_H_L 4g5z 99% -0.7559 6.5 4.0 -0.448 -0.7919
A4DAB057_5bvj_F_E 5bvj 100% -0.7212 6.5 4.0 -0.4079 -0.7583
A4DAB057_5bvp_H_L 5bvp 100% -0.755 6.5 4.0 -0.3945 -0.7969
A4DAB057_4g6j_H_L 4g6j 99% -0.7301 6.5 4.0 -0.4087 -0.7677
A4DAB057_5bvj_D_C 5bvj 100% -0.756 6.5 4.0 -0.425 -0.7941
A4DAB057_5bvj_B_A 5bvj 100% -0.7526 6.5 4.0 -0.3963 -0.7935