Conatumumab

A4DAB070 | Phase-II
TNFRSF10B/CD262/DR5/TRAILR2
G1 / None
Amgen Takeda
Phase-II
Whole mAb
AMG-655 AMG655
—
IMGT PubChem (135311444) PubChem (160677288) PubChem (347911222) PubChem (349975224) PubChem (472220497) PubChem (472386192) PubChem (474488706) PubChem (474489041) PubChem (498125034) PubChem (505574321) Thera-SAbDab YAbS
Avg A4D Score
-0.7386
Score Range
-0.78 to -0.71
Structures
3
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB070_4n90_D_E 4n90 100% -0.7114 6.5 4.0 -0.4403 -0.7469
A4DAB070_4n90_F_G 4n90 100% -0.7289 6.5 9.0 -0.4456 -0.7663
A4DAB070_4n90_H_I 4n90 100% -0.7754 6.5 4.0 -0.4613 -0.8169