Daratumumab

A4DAB081 | Cancer | Approved
ADPRC1/CD38
G1 / IgG1
Boston Medical Center Bristol-Myers Squibb Dana-Farber Cancer Institute French Innovative Leukemia Organisation Genentech Genmab Janssen Biotech Janssen Research & Development M. D. Anderson Cancer Center Syros Pharmaceuticals
Approved
Whole mAb
DALINVI Darasarex DARZALEX HuMax-CD38 JNJ-54767414 JNJ54767414
5.5
IMGT PubChem (135304352) PubChem (160671954) PubChem (178103967) PubChem (347910441) PubChem (354355058) PubChem (387060189) PubChem (440806798) PubChem (461629168) PubChem (463561439) PubChem (469691026) PubChem (472264640) PubChem (472398913) PubChem (475546927) PubChem (481101587) PubChem (481155332) PubChem (488237781) PubChem (498123744) PubChem (500131955) PubChem (513259907) Thera-SAbDab YAbS
Avg A4D Score
-0.6838
Score Range
-0.69 to -0.67
Structures
3
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB081_7dha_C_B 7dha 100% -0.6915 6.5 4.0 -0.2234 -0.7511
A4DAB081_7dun_H_L 7dun 100% -0.6903 6.5 4.0 -0.1783 -0.7563
A4DAB081_7duo_H_L 7duo 100% -0.6697 6.5 4.0 -0.1706 -0.7351