Dinutuximab

A4DAB086 | Cancer | Approved
Ganglioside GD2
G1 / IgG1
National Cancer Institute (USA) New Approaches to Neuroblastoma Therapy Consortium St. John of God Foundation United Therapeutics Corporation
Approved
Whole mAb
ch14.18 Ch14.18OP 08 OP08 OP-08
6.8
IMGT PubChem (194168552) PubChem (249565662) PubChem (347910402) PubChem (377483933) PubChem (472264642) PubChem (472406980) PubChem (481101594) PubChem (481155367) PubChem (483764322) PubChem (483765023) Thera-SAbDab YAbS
Avg A4D Score
-0.6777
Score Range
-0.72 to -0.65
Structures
7
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB086_4tuj_C_D 4tuj 95% -0.6498 6.5 4.0 N/A N/A
A4DAB086_4trp_H_L 4trp 95% -0.7177 6.5 4.0 -0.4224 -0.7509
A4DAB086_4tuo_A_B 4tuo 95% -0.6805 6.5 4.0 -0.3565 -0.7201
A4DAB086_4tuk_H_L 4tuk 95% -0.6549 6.5 4.0 -0.3192 -0.6961
A4DAB086_4tul_H_L 4tul 95% -0.6654 6.5 4.0 -0.2931 -0.7096
A4DAB086_4tuj_A_B 4tuj 95% -0.6712 6.5 4.0 -0.274 -0.7195
A4DAB086_4tuo_C_D 4tuo 95% -0.7042 6.5 4.0 -0.3851 -0.7425