Duligotuzumab

A4DAB092 | Phase-II
ERBB3/HER3
G1 / None
Genentech Roche
Phase-II
Whole mAb
MEHD-7945A MEGD7945A RG 7597 RG7597 RG-7597 RO-5541078 RO5541078
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IMGT PubChem (194168553) PubChem (347911288) PubChem (381126959) PubChem (472423075) PubChem (485482297) PubChem (485511937) PubChem (505586193) Thera-SAbDab YAbS
Avg A4D Score
-0.6912
Score Range
-0.71 to -0.67
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB092_3p0v_H_L 3p0v 98% -0.6872 6.5 4.0 -0.3902 -0.7245
A4DAB092_3p11_H_L 3p11 98% -0.7003 6.5 4.0 -0.3204 -0.7481
A4DAB092_3p0v_I_M 3p0v 98% -0.6664 6.5 4.0 -0.3317 -0.7083
A4DAB092_3p0y_H_L 3p0y 98% -0.7108 6.5 4.0 -0.3667 -0.754