Eculizumab

A4DAB097 | Immune-mediated / inflammatory disorders | Approved
C5
G2 / IgG2/4
Alexion Pharmaceuticals Brigham and Womens Hospital Chiba University Handok Inc
Approved
Whole mAb
5G1-1 5G1.1 Soliris
7
IMGT PubChem (46505429) PubChem (50070199) PubChem (103771526) PubChem (135288438) PubChem (178103466) PubChem (329976982) PubChem (354355052) PubChem (387060186) PubChem (440790757) PubChem (464013606) PubChem (468568938) PubChem (469691029) PubChem (472264644) PubChem (472422565) PubChem (481101607) PubChem (481155333) PubChem (485726231) PubChem (488204050) PubChem (496156062) PubChem (498145775) PubChem (508644802) Thera-SAbDab YAbS
Avg A4D Score
-0.7165
Score Range
-0.72 to -0.71
Structures
2
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB097_5i5k_H_L 5i5k 100% -0.7101 6.5 4.0 -0.1817 -0.7774
A4DAB097_5i5k_X_Y 5i5k 100% -0.7228 6.5 4.0 -0.1203 -0.7995