Erenumab

A4DAB109 | Neurological disorders | Approved
CALCRL
G2 / IgG2
Amgen Novartis
Approved
Whole mAb
Aimovig AMG-334 AMG334
5.2
IMGT PubChem (315661325) PubChem (336908642) PubChem (381127645) PubChem (404771503) PubChem (464013609) PubChem (468569153) PubChem (472245749) PubChem (472407793) PubChem (481155576) PubChem (483928628) Thera-SAbDab YAbS
Avg A4D Score
-0.6912
Score Range
-0.71 to -0.68
Structures
6
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB109_6umj_H_L 6umj 100% -0.6812 6.0 9.0 -0.2764 -0.7438
A4DAB109_6umh_h_l 6umh 100% -0.7092 6.0 9.0 -0.2998 -0.773
A4DAB109_6umg_H_L 6umg 100% -0.6984 6.0 9.0 -0.3488 -0.7533
A4DAB109_6umg_h_l 6umg 100% -0.6756 6.0 9.0 -0.3507 -0.7278
A4DAB109_6umh_H_L 6umh 100% -0.6758 6.0 9.0 -0.0234 -0.7772
A4DAB109_6umi_H_L 6umi 100% -0.7068 6.0 9.0 -0.2914 -0.7722