Golimumab

A4DAB133 | Immune-mediated / inflammatory disorders | Approved
TNF/TNFA
G1 / IgG1
Centocor Centocor Ortho Biotech Janssen Biotech Merck & Co Mitsubishi Tanabe Pharma Corporation Medarex
Approved
Whole mAb
CNTO-148 CNTO148 CNTO 148 MK-8259 MK8259 MK 8259 SCH 900259 SCH900259 SCH-900259 Shinponi Simponi Symposony Xinpini
5.5
IMGT PubChem (103771531) PubChem (135329319) PubChem (178103382) PubChem (329976985) PubChem (347910358) PubChem (349071996) PubChem (354355047) PubChem (440791136) PubChem (471144009) PubChem (471145846) PubChem (472219882) PubChem (472386363) PubChem (481101645) PubChem (498135571) PubChem (513904903) Thera-SAbDab YAbS
Avg A4D Score
-0.5842
Score Range
-0.61 to -0.56
Structures
6
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB133_5yoy_R_O 5yoy 100% -0.5894 7.0 4.0 N/A N/A
A4DAB133_5yoy_H_E 5yoy 100% -0.5821 7.0 4.0 -0.2162 -0.6919
A4DAB133_5yoy_P_M 5yoy 100% -0.5802 7.0 4.0 -0.2663 -0.6744
A4DAB133_5yoy_I_F 5yoy 100% -0.5866 7.0 4.0 N/A N/A
A4DAB133_5yoy_Q_N 5yoy 100% -0.5602 7.0 4.0 -0.1403 -0.6861
A4DAB133_5yoy_G_D 5yoy 100% -0.6066 7.0 4.0 -0.1708 -0.7373