Guselkumab

A4DAB137 | Immune-mediated / inflammatory disorders | Approved

Target IL23A

Isotype / Subclass G1 / IgG1

Company

Janssen Biotech MorphoSys Taiho Pharmaceutical

Clinical Status Approved

Format Whole mAb

Synonyms

CNTO-1959 CNTO 1959 CNTO1959 TREMFYA

pH Formulation 5.8

IMGT PubChem (164136017) PubChem (249565678) PubChem (347911245) PubChem (381127047) PubChem (461629172) PubChem (468568978) PubChem (472264647) PubChem (472404808) PubChem (481101646) PubChem (481154871) PubChem (498153475) PubChem (517704481) Thera-SAbDab YAbS

Avg A4D Score

-0.6623

Score Range

-0.68 to -0.65

Structures

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB137_4m6m_H_L	4m6m	100%	-0.6492	6.0	9.0	-0.3558	-0.6869
A4DAB137_4m6n_H_L	4m6n	100%	-0.6753	6.0	9.0	-0.414	-0.709

Guselkumab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2