Ipilimumab

A4DAB144 | Cancer | Approved
CTLA4/CD152
G1 / IgG1
Aduro BioTech AIO Studien gGmbH Australian and New Zealand Urogenital and Prostate Cancer Group Bavarian Nordic Big Ten Cancer Research Consortium BioGene Pharmaceutical Bristol-Myers Squibb Canadian Cancer Trials Group Dana-Farber Cancer Institute European Thoracic Oncology Platform Grupo Espanol Multidisciplinar de Melanoma Icahn School of Medicine at Mount Sinai Intergroupe Francophone de Cancerologie Thoracique Ludwig Institute for Cancer Research Massachusetts General Hospital Medarex Memorial Sloan-Kettering Cancer Center National Cancer Institute (USA) National University Hospital (Singapore) Northwestern University Olivia Newton-John Cancer Research Institute OncoTherapy Science Ono Pharmaceutical Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University College London University of California at San Francisco University of Texas M. D. Anderson Cancer Center
Approved
Whole mAb
BMS-734016 BMS734016 MDX-010 MDX010 MDX 010 MDX-10 MDX10 MDX 10 Yervoy
7
IMGT PubChem (131273201) PubChem (135287563) PubChem (178103470) PubChem (329976988) PubChem (347910341) PubChem (349072362) PubChem (354355037) PubChem (384647090) PubChem (385327547) PubChem (387061107) PubChem (442104697) PubChem (472264650) PubChem (472422344) PubChem (472634117) PubChem (475546933) PubChem (481101721) PubChem (481155433) PubChem (488211787) PubChem (496156065) PubChem (498214777) PubChem (505185876) PubChem (508534487) PubChem (508644820) PubChem (513253722) PubChem (519883502) Thera-SAbDab YAbS
Avg A4D Score
-0.6732
Score Range
-0.74 to -0.6
Structures
13
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB144_5xj3_G_H 5xj3 100% -0.6227 7.0 4.0 -0.1722 -0.7384
A4DAB144_6rp8_H_L 6rp8 100% -0.6732 6.5 4.0 -0.134 -0.7388
A4DAB144_5xj3_D_E 5xj3 100% -0.6282 7.0 4.0 -0.1827 -0.7427
A4DAB144_6rp8_h_l 6rp8 100% -0.692 6.5 4.0 -0.1115 -0.7629
A4DAB144_7elx_H_L 7elx 100% -0.6754 7.0 4.0 -0.1751 -0.7364
A4DAB144_7su1_H_L 7su1 97% -0.7371 6.5 4.0 -0.4127 -0.7763
A4DAB144_7su0_H_L 7su0 97% -0.7255 6.5 4.0 -0.4861 -0.7545
A4DAB144_5tru_H_L 5tru 100% -0.7054 6.5 4.0 -0.1892 -0.7676
A4DAB144_7su0_I_M 7su0 97% -0.7184 6.5 4.0 -0.4763 -0.7481
A4DAB144_6jc2_H_L 6jc2 100% -0.6931 6.5 4.0 -0.1845 -0.7546
A4DAB144_5xj3_A_B 5xj3 100% -0.5972 7.0 4.0 -0.154 -0.7111
A4DAB144_5tru_h_l 5tru 100% -0.6806 6.5 4.0 -0.1955 -0.7398
A4DAB144_5xj3_J_K 5xj3 100% -0.6031 7.0 4.0 -0.1936 -0.7084