Natalizumab

A4DAB174 | Immune-mediated / inflammatory disorders | Approved
ITGA4/CD49D
G4 / IgG4
Biogen Biogen Idec Elan Corporation Perrigo
Approved
Whole mAb
AN 10022 AN10022 AN-10022 AN 100226 AN-100226 AN100226 Antegren BG-00002 BG 00002 BG00002 BG-0002 BG0002 BG 0002 BG2 BG-2 BG 2 Tysabri
6.1
IMGT PubChem (46505849) PubChem (50069162) PubChem (103771320) PubChem (135314782) PubChem (178103204) PubChem (329976990) PubChem (354355048) PubChem (402354775) PubChem (402355924) PubChem (440790360) PubChem (472207180) PubChem (472399420) PubChem (472677714) PubChem (481101759) PubChem (485727148) PubChem (488221355) PubChem (496156076) PubChem (496720466) PubChem (498149682) PubChem (505238003) PubChem (507700823) PubChem (508644822) PubChem (513262136) PubChem (513686217) PubChem (519958020) PubChem (521868416) Thera-SAbDab YAbS
Avg A4D Score
-0.7352
Score Range
-0.75 to -0.73
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB174_6fg2_H_L 6fg2 99% -0.7325 6.5 4.0 -0.6274 -0.7462
A4DAB174_4irz_H_L 4irz 99% -0.7276 6.5 9.0 -0.5588 -0.7497
A4DAB174_6fg1_H_L 6fg1 99% -0.752 6.5 9.0 -0.5659 -0.776
A4DAB174_6fg2_I_M 6fg2 99% -0.7288 6.5 9.0 -0.6039 -0.7449