Necitumumab

A4DAB177 | Cancer | Approved
EGFR/ERBB1/HER1
G1 / IgG1
ImClone Systems Eli Lilly
Approved
Whole mAb
IMC-11F8 IMC 11F8 IMC11F8 LY 3012211 LY3012211 LY-3012211 Portraza Portrazza
6
Avg A4D Score
-0.6425
Score Range
-0.69 to -0.61
Structures
13
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB177_3b2u_C_D 3b2u 100% -0.6133 6.5 9.0 -0.0336 -0.6869
A4DAB177_3b2v_H_L 3b2v 100% -0.6868 6.0 9.0 -0.0768 -0.7634
A4DAB177_6b3s_H_L 6b3s 100% -0.6332 6.5 9.0 -0.0303 -0.7098
A4DAB177_6b3s_C_D 6b3s 100% -0.6461 6.5 4.0 -0.0518 -0.7216
A4DAB177_3b2u_J_K 3b2u 100% -0.6608 6.5 9.0 -0.037 -0.7392
A4DAB177_3b2u_H_L 3b2u 100% -0.6387 6.5 9.0 -0.0471 -0.713
A4DAB177_6b3s_F_G 6b3s 100% -0.6381 6.5 9.0 -0.0377 -0.7141
A4DAB177_3b2u_N_O 3b2u 100% -0.638 6.5 9.0 0.0074 -0.7189
A4DAB177_3b2u_W_X 3b2u 100% -0.663 6.5 4.0 -0.0478 -0.7405
A4DAB177_6b3s_J_K 6b3s 100% -0.6279 6.5 9.0 -0.0368 -0.7029
A4DAB177_3b2u_F_G 3b2u 100% -0.6515 6.5 9.0 -0.007 -0.7329
A4DAB177_3b2u_Q_R 3b2u 100% -0.6423 6.5 9.0 -0.0198 -0.7205
A4DAB177_3b2u_T_U 3b2u 100% -0.6133 6.5 9.0 0.0155 -0.6926