Nipocalimab

A4DAB180 | Immune-mediated / inflammatory disorders | Preregistration

Target FCGRT/FcRn

Isotype / Subclass G1 / IgG1

Company

Momenta

Clinical Status Preregistration

Format Whole mAb

Synonyms

JNJ 80202135 JNJ-80202135 JNJ80202135 M 281 M-281 M281

pH Formulation —

IMGT PubChem (385610257) PubChem (440234683) PubChem (472419996) PubChem (481155570) PubChem (498145564) PubChem (505057000) PubChem (505850122) PubChem (507510720) PubChem (513757561) Thera-SAbDab YAbS

Avg A4D Score

-0.7032

Score Range

-0.73 to -0.68

Structures

2

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB180_5whj_H_L	5whj	97%	-0.7288	6.0	9.0	-0.3067	-0.7809
A4DAB180_5whk_H_L	5whk	97%	-0.6776	6.0	9.0	-0.2681	-0.729

Nipocalimab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2