Global Registry
A4D-Ab
Ocrelizumab
A4DAB186
|
Immune-mediated / inflammatory disorders
|
Approved
Target
MS4A1/CD20
Isotype / Subclass
G1 / IgG1
Company
Biogen
Biogen Idec
Chugai Pharmaceutical
Genentech
Roche
Clinical Status
Approved
Format
Whole mAb
Synonyms
Ocrevus
PRO 70769
PRO-70769
PRO70769
R 1594
R1594
R-1594
RG 1594
RG-1594
RG1594
RO4964913
RO-4964913
RO 4964913
pH Formulation
5.3
IMGT
PubChem (135357140)
PubChem (160698363)
PubChem (223365915)
PubChem (347911266)
PubChem (472264656)
PubChem (472386062)
PubChem (481101767)
PubChem (481155374)
PubChem (483558691)
PubChem (483559307)
PubChem (517704478)
Thera-SAbDab
YAbS
Avg A4D Score
-0.6659
Score Range
-0.67
Structures
1
Show Structure Profiles
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity
Associated Structural Profiles
Level 2
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Column Filters
Min Seq. Identity (%)
0
Min Avg A4D Score
-5.0
Max Avg A4D Score
2.0
Min pH (min agg. prop.)
0.0
Max pH (max agg. prop.)
14.0
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Structure ID
Source PDB
Seq. Identity
Avg. A4D Score
pH (Min Agg.)
pH (Max Agg.)
Score CDR
Score non-CDR
A4DAB186_4k7p_Y_X
4k7p
98%
-0.6659
6.5
9.0
-0.0795
-0.7393