Ofatumumab

A4DAB188 | Cancer | Approved
MS4A1/CD20
G1 / IgG1
Genmab GlaxoSmithKline Mundipharma International National Cancer Centre (Singapore) Novartis Roswell Park Cancer Institute University Health Network
Approved
Whole mAb
Arzerra GSK-1841157 GSK1841157 GSK 1841157 Kesimpta OMB-157 OMB157 OMB 157
['6.5', '5.5']
IMGT PubChem (103771534) PubChem (135302238) PubChem (178103384) PubChem (329976991) PubChem (347910355) PubChem (349995626) PubChem (387060162) PubChem (440790866) PubChem (464013613) PubChem (468568984) PubChem (472264657) PubChem (472399120) PubChem (481101769) PubChem (481155375) PubChem (486382384) PubChem (488413003) PubChem (498129214) PubChem (505187026) PubChem (508534104) Thera-SAbDab YAbS
Avg A4D Score
-0.701
Score Range
-0.71 to -0.69
Structures
3
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB188_6y92_C_D 6y92 100% -0.7117 7.0 4.0 -0.2257 -0.7747
A4DAB188_6y92_H_L 6y92 100% -0.702 7.0 4.0 -0.1958 -0.7677
A4DAB188_3giz_H_L 3giz 100% -0.6894 6.5 4.0 -0.1793 -0.7556