Ontamalimab

A4DAB194 | Immune-mediated / inflammatory disorders | Phase-III

Target MADCAM1

Isotype / Subclass G2 / IgG2

Company

Pfizer Takeda

Clinical Status Phase-III

Format Whole mAb

Synonyms

PF-00547659 PF00547659 PF-547659 PF547659 SHP-647 SHP647 SHP 647 TAK-647 TAK647 TAK 647

pH Formulation —

IMGT PubChem (160682419) PubChem (328083443) PubChem (381128284) PubChem (404772730) PubChem (472406628) PubChem (476262744) PubChem (476269352) Thera-SAbDab YAbS

Avg A4D Score

-0.7058

Score Range

-0.71 to -0.7

Structures

2

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB194_4hcr_H_L	4hcr	100%	-0.7034	6.5	4.0	-0.3121	-0.7614
A4DAB194_4hcr_M_N	4hcr	100%	-0.7082	6.5	4.0	-0.3511	-0.7614

Ontamalimab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2