Ruplizumab

A4DAB232 | Phase-II
CD40LG/CD154
G1 / None
Biogen
Phase-II
Whole mAb
BG 9588 BG-9588 BG9588
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IMGT PubChem (135337719) PubChem (160709140) PubChem (404770272) PubChem (472408190) PubChem (474488747) PubChem (474489071) PubChem (505879904) PubChem (513906257) PubChem (517704475) Thera-SAbDab YAbS
Avg A4D Score
-0.7209
Score Range
-0.73 to -0.71
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB232_1i9r_X_Y 1i9r 100% -0.7226 6.5 9.0 -0.4474 -0.7576
A4DAB232_6w4w_H_L 6w4w 100% -0.7265 6.5 9.0 -0.3921 -0.7691
A4DAB232_1i9r_H_L 1i9r 100% -0.7137 6.0 9.0 -0.4143 -0.7518
A4DAB232_1i9r_K_M 1i9r 100% -0.7207 6.5 9.0 -0.4371 -0.7568