Global Registry
A4D-Ab
Sarilumab
A4DAB234
|
Immune-mediated / inflammatory disorders
|
Approved
Target
IL6R/CD126
Isotype / Subclass
G1 / IgG1
Company
Asahi Kasei Pharma Corp
Regeneron Pharmaceuticals
Sanofi
Clinical Status
Approved
Format
Whole mAb
Synonyms
Kevzara
REGN-88
REGN88
REGN 88
SAR-153191
SAR153191
SAR 153191
pH Formulation
6
IMGT
PubChem (160687628)
PubChem (249565679)
PubChem (347911238)
PubChem (381126483)
PubChem (406846983)
PubChem (406850446)
PubChem (472264661)
PubChem (472400783)
PubChem (481101845)
PubChem (481155380)
PubChem (518314158)
Thera-SAbDab
YAbS
Avg A4D Score
-0.7434
Score Range
-0.74
Structures
1
Show Structure Profiles
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity
Associated Structural Profiles
Level 2
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Column Filters
Min Seq. Identity (%)
0
Min Avg A4D Score
-5.0
Max Avg A4D Score
2.0
Min pH (min agg. prop.)
0.0
Max pH (max agg. prop.)
14.0
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Structure ID
Source PDB
Seq. Identity
Avg. A4D Score
pH (Min Agg.)
pH (Max Agg.)
Score CDR
Score non-CDR
A4DAB234_8iow_H_L
8iow
100%
-0.7434
7.0
4.0
-0.7916
-0.7379