Global Registry
A4D-Ab
Tanezumab
A4DAB256
|
Neurological disorders
|
Phase-III
Target
NGFB
Isotype / Subclass
G2 / IgG2
Company
Rinat Neuroscience
Pfizer
Clinical Status
Phase-III
Format
Whole mAb
Synonyms
PF-04383119
PF04383119
PF-4383119
PF4383119
RI-624
RI624
RI 624
RN-624
RN624
RN 624
pH Formulation
—
IMGT
PubChem (135325228)
PubChem (160682307)
PubChem (252166625)
PubChem (347911318)
PubChem (349404150)
PubChem (472422556)
PubChem (472435544)
PubChem (472440370)
PubChem (482588855)
PubChem (498125446)
PubChem (505886998)
Thera-SAbDab
YAbS
Avg A4D Score
-0.624
Score Range
-0.62
Structures
1
Show Structure Profiles
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity
Associated Structural Profiles
Level 2
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Column Filters
Min Seq. Identity (%)
0
Min Avg A4D Score
-5.0
Max Avg A4D Score
2.0
Min pH (min agg. prop.)
0.0
Max pH (max agg. prop.)
14.0
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Structure ID
Source PDB
Seq. Identity
Avg. A4D Score
pH (Min Agg.)
pH (Max Agg.)
Score CDR
Score non-CDR
A4DAB256_4edw_H_L
4edw
100%
-0.624
6.5
9.0
-0.1151
-0.6881