Tezepelumab

A4DAB262 | Immune-mediated / inflammatory disorders | Approved
TSLP
G2 / IgG2
Amgen AstraZeneca Bispebjerg Hospital Lund University MedImmune University of Copenhagen University of Newcastle in Australia
Approved
Whole mAb
AMG 157 AMG-157 AMG157 MEDI-9929 MEDI9929 MEDI 9929 Tezspire
5.2
IMGT PubChem (310264714) PubChem (318464472) PubChem (381127637) PubChem (404772532) PubChem (472404557) PubChem (476262700) PubChem (476269307) PubChem (483928625) PubChem (498151999) PubChem (513906464) Thera-SAbDab YAbS
Avg A4D Score
-0.7077
Score Range
-0.71
Structures
1
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB262_5j13_C_B 5j13 100% -0.7077 6.5 4.0 -0.6069 -0.7216