Volrustomig

A4DAB299 | Cancer | Phase-III
CTLA4/CD152;PDCD1/CD279/PD1
G1 / IgG1
AstraZeneca
Phase-III
Bispecific mAb
MEDI-5752 MEDI5752 MEDI 5752
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IMGT PubChem (462764893) PubChem (472420293) PubChem (476000956) Thera-SAbDab YAbS
Avg A4D Score
-0.6508
Score Range
-0.67 to -0.64
Structures
3
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB299_5ggu_H_L 5ggu 100% -0.6364 6.5 4.0 -0.0231 -0.7205
A4DAB299_5ggv_H_L 5ggv 100% -0.6749 6.5 4.0 -0.0458 -0.7596
A4DAB299_5ggu_A_B 5ggu 100% -0.641 6.5 4.0 -0.049 -0.7223