Coprelotamab / 5tdn

A4DAB072_5tdn_D_C | Source PDB: 5tdn | Chains: D, C | Done
98.68
Yes
10 Å
Yes
Avg A4D Score
-0.6936
Max Score
1.5053
Min Score
-3.6428
Total Score
-291.99
Score CDR
-0.4911
Score non-CDR
-0.719

Calculation Parameters

Chain Sequence(s) EVLVESGGGLQPGGSLRLSCAASGFNIKDTYIHWVREAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPGTAALGCLVKDYFPEPVTVSWNSGALTGVHTFPAVLQSSGLYLKSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQKKPGKAPKLLIYSASFLESGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVECLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) D (Heavy), C (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6428
Maximum Score 1.5053
Average Score -0.6936
Total Score -291.9856

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E D -1.7460 Soluble
2 V D -0.5704 Soluble
4 L D 0.9638 Aggregation-prone
5 V D 1.5053 Aggregation-prone
6 E D 0.0000 Buried
7 S D -0.3393 Soluble
8 G D -0.9077 Soluble
9 G D -0.3636 Soluble
11 G D 0.1815 Aggregation-prone
12 L D 0.3570 Aggregation-prone
14 Q D -1.5722 Soluble
15 P D -1.7007 Soluble
16 G D -1.4679 Soluble
17 G D -1.1619 Soluble
18 S D -1.0843 Soluble
19 L D -1.0207 Soluble
20 R D -1.9881 Soluble
21 L D 0.0000 Buried
22 S D -0.2802 Soluble
23 C D 0.0000 Buried
24 A D 0.2872 Aggregation-prone
25 A D -0.1124 Soluble
26 S D -0.4836 Soluble
27 G D -1.0505 Soluble
28 F D -1.2478 Soluble
29 N D -2.3589 Soluble
30 I D 0.0000 Buried
35 K D -3.0204 Soluble
36 D D -3.0952 Soluble
37 T D 0.0000 Buried
38 Y D -0.6287 Soluble
39 I D 0.0000 Buried
40 H D 0.0000 Buried
41 W D 0.0000 Buried
42 V D 0.0000 Buried
43 R D 0.0000 Buried
44 E D -0.9995 Soluble
45 A D -1.2978 Soluble
46 P D -1.2991 Soluble
47 G D -1.6451 Soluble
48 K D -2.4637 Soluble
49 G D -1.6648 Soluble
50 L D 0.0000 Buried
51 E D -1.1498 Soluble
52 W D 0.0000 Buried
53 V D 0.0000 Buried
54 A D 0.0000 Buried
55 R D -0.5822 Soluble
56 I D 0.0000 Buried
57 Y D -0.4478 Soluble
58 P D -1.1823 Soluble
59 T D -1.3896 Soluble
62 N D -1.1661 Soluble
63 G D -0.4497 Soluble
64 Y D 0.4690 Aggregation-prone
65 T D -0.4642 Soluble
66 R D -1.9958 Soluble
67 Y D -1.8384 Soluble
68 A D -1.8112 Soluble
69 D D -2.6344 Soluble
70 S D -1.7207 Soluble
71 V D 0.0000 Buried
72 K D -2.8149 Soluble
74 G D -1.6983 Soluble
75 R D -1.2264 Soluble
76 F D 0.0000 Buried
77 T D -1.0104 Soluble
78 I D 0.0000 Buried
79 S D -0.0575 Soluble
80 A D -0.7816 Soluble
81 D D -1.4749 Soluble
82 T D -1.9574 Soluble
83 S D -1.6265 Soluble
84 K D -2.2198 Soluble
85 N D -1.8365 Soluble
86 T D -0.9519 Soluble
87 A D 0.0000 Buried
88 Y D -0.4080 Soluble
89 L D 0.0000 Buried
90 Q D -1.0458 Soluble
91 M D 0.0000 Buried
92 N D -1.2979 Soluble
93 S D -1.2463 Soluble
94 L D 0.0000 Buried
95 R D -2.4374 Soluble
96 A D -1.7710 Soluble
97 E D -2.3204 Soluble
98 D D 0.0000 Buried
99 T D -0.7001 Soluble
100 A D 0.0000 Buried
101 V D 0.1885 Aggregation-prone
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
105 S D 0.0000 Buried
106 R D -0.3700 Soluble
107 W D -0.3866 Soluble
108 G D 0.0000 Buried
109 G D -0.9492 Soluble
110 D D -1.8005 Soluble
111 G D 0.0000 Buried
112 F D 0.8108 Aggregation-prone
113 Y D 0.7280 Aggregation-prone
114 A D 0.0000 Buried
115 M D 0.0000 Buried
116 D D 0.1153 Aggregation-prone
117 Y D 0.5462 Aggregation-prone
118 W D 0.0834 Aggregation-prone
119 G D 0.0000 Buried
120 Q D -1.1572 Soluble
121 G D 0.0000 Buried
122 T D 0.1706 Aggregation-prone
123 L D 0.6155 Aggregation-prone
124 V D 0.0000 Buried
125 T D -0.2487 Soluble
126 V D 0.0000 Buried
127 S D -0.7175 Soluble
128 S D -0.6754 Soluble
129 A D -0.4106 Soluble
130 S D -0.5225 Soluble
131 T D -0.6734 Soluble
132 K D -1.1189 Soluble
133 G D -1.3307 Soluble
134 P D 0.0000 Buried
135 S D -0.4368 Soluble
136 V D 0.0000 Buried
137 F D 0.0000 Buried
138 P D -1.0537 Soluble
139 L D 0.0000 Buried
140 A D -0.7942 Soluble
141 P D -0.4141 Soluble
142 G D -0.6474 Soluble
143 T D -0.4642 Soluble
144 A D -0.2048 Soluble
145 A D 0.0000 Buried
146 L D 0.0000 Buried
147 G D 0.0000 Buried
148 C D 0.0000 Buried
149 L D 0.0000 Buried
150 V D 0.0000 Buried
151 K D -0.2635 Soluble
152 D D -0.3767 Soluble
153 Y D 0.0000 Buried
154 F D 0.0000 Buried
155 P D 0.0000 Buried
156 E D -0.5181 Soluble
157 P D -0.7654 Soluble
158 V D -0.7553 Soluble
159 T D -0.6394 Soluble
160 V D -0.2237 Soluble
161 S D -0.3955 Soluble
162 W D 0.0000 Buried
163 N D -0.6617 Soluble
164 S D -0.6378 Soluble
165 G D -0.4844 Soluble
166 A D -0.1700 Soluble
167 L D 0.1239 Aggregation-prone
168 T D -0.0866 Soluble
170 G D -0.3374 Soluble
171 V D 0.1294 Aggregation-prone
172 H D -0.3422 Soluble
173 T D -0.1690 Soluble
174 F D 0.0000 Buried
175 P D -0.4246 Soluble
176 A D 0.0689 Aggregation-prone
177 V D 0.3273 Aggregation-prone
178 L D 1.0632 Aggregation-prone
179 Q D 0.2194 Aggregation-prone
180 S D -0.0863 Soluble
181 S D -0.2013 Soluble
182 G D 0.0402 Aggregation-prone
183 L D 0.1198 Aggregation-prone
184 Y D 0.3795 Aggregation-prone
186 L D 0.0000 Buried
187 K D 0.0000 Buried
188 S D 0.0000 Buried
189 V D 0.0000 Buried
190 V D 0.0000 Buried
191 T D -0.1913 Soluble
192 V D 0.0000 Buried
193 P D -0.4843 Soluble
194 S D -0.4979 Soluble
195 S D -0.5480 Soluble
196 S D -0.5025 Soluble
197 L D -0.6619 Soluble
198 G D -1.0363 Soluble
199 T D -0.6417 Soluble
200 Q D -1.0864 Soluble
201 T D -1.0577 Soluble
202 Y D 0.0000 Buried
203 I D -1.0961 Soluble
204 C D 0.0000 Buried
205 N D -1.4563 Soluble
206 V D 0.0000 Buried
207 N D -2.0710 Soluble
208 H D 0.0000 Buried
209 K D -2.7876 Soluble
210 P D -1.5597 Soluble
211 S D -1.8337 Soluble
212 N D -2.5937 Soluble
213 T D -2.1167 Soluble
214 K D -2.7575 Soluble
215 V D -1.6159 Soluble
216 D D -2.4595 Soluble
217 K D -2.0199 Soluble
218 K D -2.3086 Soluble
219 V D 0.0000 Buried
220 E D -2.4301 Soluble
221 P D -1.3466 Soluble
2 I C -0.4575 Soluble
3 Q C -1.5878 Soluble
4 M C 0.0000 Buried
5 T C -1.3752 Soluble
6 Q C 0.0000 Buried
7 S C -0.8877 Soluble
8 P C -0.6390 Soluble
9 S C -0.8987 Soluble
10 S C -0.8209 Soluble
11 L C -0.6050 Soluble
12 S C -0.9597 Soluble
13 A C -1.0995 Soluble
14 S C -0.9070 Soluble
15 V C 0.0725 Aggregation-prone
16 G C -0.4948 Soluble
17 D C -1.6650 Soluble
18 R C -2.2070 Soluble
19 V C 0.0000 Buried
20 T C -0.6157 Soluble
21 I C 0.0000 Buried
22 T C -0.7967 Soluble
23 C C 0.0000 Buried
24 R C -2.7870 Soluble
25 A C 0.0000 Buried
26 S C -1.7192 Soluble
27 Q C -2.1559 Soluble
28 D C -2.3519 Soluble
29 V C 0.0000 Buried
36 N C -1.8172 Soluble
37 T C -0.8405 Soluble
38 A C 0.0875 Aggregation-prone
39 V C 0.0000 Buried
40 A C 0.0000 Buried
41 W C 0.0000 Buried
42 Y C 0.0000 Buried
43 Q C 0.0000 Buried
44 K C 0.0000 Buried
45 K C -1.5355 Soluble
46 P C -1.4215 Soluble
47 G C -1.6503 Soluble
48 K C -2.5366 Soluble
49 A C -1.5413 Soluble
50 P C 0.0000 Buried
51 K C -1.2371 Soluble
52 L C 0.0000 Buried
53 L C 0.0000 Buried
54 I C 0.0000 Buried
55 Y C 0.0000 Buried
56 S C 0.4796 Aggregation-prone
57 A C 0.0000 Buried
65 S C 0.2650 Aggregation-prone
66 F C 1.4635 Aggregation-prone
67 L C 0.9045 Aggregation-prone
68 E C 0.1031 Aggregation-prone
69 S C -0.2289 Soluble
70 G C -0.4995 Soluble
71 V C -0.3165 Soluble
72 P C -0.3307 Soluble
74 S C -0.4190 Soluble
75 R C -0.6898 Soluble
76 F C 0.0000 Buried
77 S C -0.0348 Soluble
78 G C -0.1107 Soluble
79 S C -0.7656 Soluble
80 R C -1.7746 Soluble
83 S C -1.4315 Soluble
84 G C -1.8128 Soluble
85 T C -2.1488 Soluble
86 D C -2.0479 Soluble
87 F C 0.0000 Buried
88 T C -0.8149 Soluble
89 L C 0.0000 Buried
90 T C -0.6158 Soluble
91 I C 0.0000 Buried
92 S C -1.3205 Soluble
93 S C -0.9922 Soluble
94 L C 0.0000 Buried
95 Q C -0.6276 Soluble
96 P C -1.3697 Soluble
97 E C -2.0507 Soluble
98 D C 0.0000 Buried
99 F C -0.9251 Soluble
100 A C 0.0000 Buried
101 T C -0.8383 Soluble
102 Y C 0.0000 Buried
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 Q C 0.0000 Buried
106 Q C 0.0000 Buried
107 H C 0.4926 Aggregation-prone
108 Y C 0.5543 Aggregation-prone
109 T C 0.5183 Aggregation-prone
114 T C -0.1654 Soluble
115 P C -0.5229 Soluble
116 P C 0.0000 Buried
117 T C -0.2869 Soluble
118 F C -0.4341 Soluble
119 G C 0.0000 Buried
120 Q C -1.9060 Soluble
121 G C 0.0000 Buried
122 T C 0.0000 Buried
123 K C -1.4992 Soluble
124 V C 0.0000 Buried
125 E C -1.2697 Soluble
126 I C 0.0000 Buried
127 K C -1.8164 Soluble
128 R C -1.0991 Soluble
129 T C -0.2334 Soluble
130 V C 0.2402 Aggregation-prone
131 A C 0.0850 Aggregation-prone
132 A C -0.1165 Soluble
133 P C 0.0000 Buried
134 S C -0.1543 Soluble
135 V C 0.0000 Buried
136 F C 0.1725 Aggregation-prone
137 I C 0.1725 Aggregation-prone
138 F C 0.0000 Buried
139 P C -0.5118 Soluble
140 P C 0.0000 Buried
141 S C -1.5250 Soluble
142 D C -2.7717 Soluble
143 E C -2.5768 Soluble
144 Q C 0.0000 Buried
145 L C -2.1651 Soluble
146 K C -2.7779 Soluble
147 S C -1.7756 Soluble
148 G C -1.2963 Soluble
149 T C -1.2180 Soluble
150 A C 0.0000 Buried
151 S C 0.0000 Buried
152 V C 0.0000 Buried
153 E C 0.0000 Buried
154 C C 0.0000 Buried
155 L C 0.0000 Buried
156 L C 0.0000 Buried
157 N C 0.0000 Buried
158 N C -0.8948 Soluble
159 F C 0.0000 Buried
160 Y C 0.0000 Buried
161 P C -1.8877 Soluble
162 R C -3.1267 Soluble
163 E C -3.2788 Soluble
164 A C -2.3689 Soluble
165 K C -2.2485 Soluble
166 V C -0.9640 Soluble
167 Q C -0.3980 Soluble
168 W C 0.0000 Buried
169 K C -0.4449 Soluble
170 V C 0.0000 Buried
171 D C -2.1332 Soluble
172 N C -1.6073 Soluble
173 A C -0.2867 Soluble
174 L C 0.7680 Aggregation-prone
175 Q C -0.2221 Soluble
176 S C -0.6394 Soluble
177 G C -1.2950 Soluble
178 N C -1.6378 Soluble
179 S C -1.4897 Soluble
180 Q C -1.5043 Soluble
181 E C -1.9197 Soluble
182 S C -1.0249 Soluble
183 V C -0.8352 Soluble
184 T C 0.0000 Buried
185 E C -2.1548 Soluble
186 Q C 0.0000 Buried
187 D C -1.9649 Soluble
188 S C -1.9718 Soluble
189 K C -2.3312 Soluble
190 D C -1.5129 Soluble
191 S C 0.0000 Buried
192 T C 0.0000 Buried
193 Y C 0.0000 Buried
194 S C 0.0000 Buried
195 L C 0.0000 Buried
196 S C 0.0000 Buried
197 S C 0.0000 Buried
198 T C 0.0000 Buried
199 L C 0.0000 Buried
200 T C -0.7376 Soluble
201 L C -0.8661 Soluble
202 S C -1.3128 Soluble
203 K C -2.0916 Soluble
204 A C -1.9200 Soluble
205 D C -2.6252 Soluble
206 Y C 0.0000 Buried
207 E C -3.4214 Soluble
208 K C -3.6428 Soluble
209 H C -3.0344 Soluble
210 K C -3.3391 Soluble
211 V C -1.6144 Soluble
212 Y C 0.0000 Buried
213 A C 0.0000 Buried
214 C C 0.0000 Buried
215 E C -0.6569 Soluble
216 V C 0.0000 Buried
217 T C -1.1774 Soluble
218 H C 0.0000 Buried
219 Q C -1.5701 Soluble
220 G C -0.4264 Soluble
221 L C -0.2239 Soluble
222 S C -0.4559 Soluble
223 S C -0.4255 Soluble
224 P C -0.5528 Soluble
225 V C -0.0568 Soluble
226 T C -0.4430 Soluble
227 K C -0.6525 Soluble
228 S C -0.5308 Soluble
229 F C -0.8367 Soluble
230 N C -1.8726 Soluble
231 R C -2.4486 Soluble
232 G C -1.9541 Soluble
233 E C -2.1627 Soluble
234 C C -0.4020 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7024 3.1121 CSV PDB
4.5 -0.7474 3.0278 CSV PDB
5.0 -0.7996 2.9186 CSV PDB
5.5 -0.8498 2.7982 CSV PDB
6.0 -0.8865 2.6738 CSV PDB
6.5 -0.8999 2.547 CSV PDB
7.0 -0.8891 2.419 CSV PDB
7.5 -0.8618 2.3624 CSV PDB
8.0 -0.825 2.3617 CSV PDB
8.5 -0.7808 2.3614 CSV PDB
9.0 -0.7293 2.3611 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH