Adintrevimab / 7u2d

A4DAB006_7u2d_H_L | Source PDB: 7u2d | Chains: H, L | Done
99.58
Yes
10 Å
Yes
Avg A4D Score
-0.6331
Max Score
1.3155
Min Score
-3.1629
Total Score
-274.75
Score CDR
-0.2532
Score non-CDR
-0.6905

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYYMNWVRQAPGKGLEWVSSISEDGYSTYYPDSLKGRFTISRDSAKNSLYLQMNSLRADDTAVYYCARDFSGHTAWAGTGFEYWGQGTLVTVSSASTKGPSVFPLAPGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSQPVLTQPPSVSGAPGQRITISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGSSSRNSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSVLYTFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1629
Maximum Score 1.3155
Average Score -0.6331
Total Score -274.7451

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -2.1326 Soluble
2 V H -1.2485 Soluble
3 Q H -1.5117 Soluble
4 L H 0.0000 Buried
5 V H 0.1592 Aggregation-prone
6 E H 0.0000 Buried
7 S H -0.7572 Soluble
8 G H -1.1070 Soluble
9 G H -0.7891 Soluble
11 G H 0.0000 Buried
12 L H -0.2451 Soluble
13 V H 0.0000 Buried
14 K H -2.0390 Soluble
15 P H -2.1779 Soluble
16 G H -1.7804 Soluble
17 G H -1.4132 Soluble
18 S H -1.4661 Soluble
19 L H -1.2177 Soluble
20 R H -2.0972 Soluble
21 L H 0.0000 Buried
22 S H -0.5564 Soluble
23 C H 0.0000 Buried
24 A H -0.4294 Soluble
25 A H 0.0000 Buried
26 S H -1.0103 Soluble
27 G H -1.2758 Soluble
28 F H -0.5193 Soluble
29 T H -0.1925 Soluble
30 F H 0.0000 Buried
35 S H -1.0535 Soluble
36 S H -0.6466 Soluble
37 Y H -0.3694 Soluble
38 Y H -0.2585 Soluble
39 M H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H -0.5676 Soluble
44 Q H -0.8827 Soluble
45 A H -1.2543 Soluble
46 P H -0.9998 Soluble
47 G H -1.4753 Soluble
48 K H -2.2359 Soluble
49 G H -1.4205 Soluble
50 L H 0.0000 Buried
51 E H -0.8557 Soluble
52 W H 0.0000 Buried
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 S H 0.0000 Buried
56 I H 0.0000 Buried
57 S H 0.0000 Buried
58 E H -1.4379 Soluble
59 D H -1.9020 Soluble
62 G H -0.7579 Soluble
63 Y H 0.4989 Aggregation-prone
64 S H 0.1131 Aggregation-prone
65 T H 0.3849 Aggregation-prone
66 Y H 0.4783 Aggregation-prone
67 Y H -0.1559 Soluble
68 P H 0.0000 Buried
69 D H -2.3606 Soluble
70 S H -1.8857 Soluble
71 L H 0.0000 Buried
72 K H -2.5905 Soluble
74 G H -1.7940 Soluble
75 R H -1.3229 Soluble
76 F H 0.0000 Buried
77 T H -0.5384 Soluble
78 I H 0.0000 Buried
79 S H -0.2205 Soluble
80 R H -1.1169 Soluble
81 D H -1.5985 Soluble
82 S H -1.6716 Soluble
83 A H -1.2261 Soluble
84 K H -2.1976 Soluble
85 N H -1.7329 Soluble
86 S H 0.0000 Buried
87 L H 0.0000 Buried
88 Y H -0.6266 Soluble
89 L H 0.0000 Buried
90 Q H -1.2426 Soluble
91 M H 0.0000 Buried
92 N H -1.5122 Soluble
93 S H -1.4493 Soluble
94 L H 0.0000 Buried
95 R H -3.0212 Soluble
96 A H -2.0504 Soluble
97 D H -2.3683 Soluble
98 D H 0.0000 Buried
99 T H -0.8420 Soluble
100 A H 0.0000 Buried
101 V H 0.1416 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 D H 0.0000 Buried
108 F H 0.0000 Buried
109 S H -0.5201 Soluble
110 G H -0.9464 Soluble
111 H H -1.1977 Soluble
111A T H -0.5898 Soluble
111B A H -0.2535 Soluble
112B W H -0.0131 Soluble
112A A H -0.1964 Soluble
112 G H -0.0064 Soluble
113 T H 0.0949 Aggregation-prone
114 G H 0.0000 Buried
115 F H 0.0000 Buried
116 E H -0.3522 Soluble
117 Y H -0.1233 Soluble
118 W H -0.4157 Soluble
119 G H 0.0000 Buried
120 Q H -1.1006 Soluble
121 G H -0.4051 Soluble
122 T H -0.1861 Soluble
123 L H 0.0265 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.6543 Soluble
126 V H 0.0000 Buried
127 S H -0.9736 Soluble
128 S H -0.9764 Soluble
129 A H -0.5108 Soluble
130 S H -0.6328 Soluble
131 T H -0.6146 Soluble
132 K H -1.1505 Soluble
133 G H -1.3370 Soluble
134 P H -0.5495 Soluble
135 S H -0.1972 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.0017 Soluble
139 L H 0.0000 Buried
140 A H -1.0722 Soluble
141 P H -0.9011 Soluble
142 G H -0.6537 Soluble
143 T H -0.5162 Soluble
144 A H -0.3381 Soluble
145 A H -0.1101 Soluble
146 L H 0.0000 Buried
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.0000 Buried
150 V H 0.0000 Buried
151 K H 0.0000 Buried
152 D H -0.1869 Soluble
153 Y H 0.0000 Buried
154 F H 0.0000 Buried
155 P H 0.0000 Buried
156 E H -0.8392 Soluble
157 P H -0.8532 Soluble
158 V H -0.7763 Soluble
159 T H -0.6092 Soluble
160 V H -0.2911 Soluble
161 S H -0.3277 Soluble
162 W H 0.0000 Buried
163 N H -0.6986 Soluble
164 S H -0.6053 Soluble
165 G H -0.4542 Soluble
166 A H -0.1903 Soluble
167 L H 0.0511 Aggregation-prone
168 T H -0.1186 Soluble
169 S H -0.2511 Soluble
170 G H -0.3080 Soluble
171 V H 0.2435 Aggregation-prone
172 H H -0.0252 Soluble
173 T H 0.0540 Aggregation-prone
174 F H 0.0000 Buried
175 P H -0.1489 Soluble
176 A H 0.1660 Aggregation-prone
177 V H 0.0000 Buried
178 L H 1.0089 Aggregation-prone
179 Q H 0.2062 Aggregation-prone
180 S H -0.1476 Soluble
181 S H -0.1830 Soluble
182 G H 0.0369 Aggregation-prone
183 L H 0.1435 Aggregation-prone
184 Y H 0.3328 Aggregation-prone
185 S H 0.0000 Buried
186 L H 0.0000 Buried
187 S H 0.0000 Buried
188 S H 0.0000 Buried
189 V H 0.2085 Aggregation-prone
190 V H 0.0000 Buried
191 T H -0.2533 Soluble
192 V H 0.0000 Buried
193 P H -0.5766 Soluble
194 S H -0.6199 Soluble
195 S H -0.6614 Soluble
196 S H -0.6292 Soluble
197 L H -0.8413 Soluble
198 G H -0.9847 Soluble
199 T H -0.7682 Soluble
200 Q H -1.2625 Soluble
201 T H -1.2048 Soluble
202 Y H 0.0000 Buried
203 I H -1.3037 Soluble
204 C H 0.0000 Buried
205 N H 0.0000 Buried
206 V H 0.0000 Buried
207 N H -1.9207 Soluble
208 H H 0.0000 Buried
209 K H -2.8641 Soluble
210 P H -1.6152 Soluble
211 S H -1.8321 Soluble
212 N H -2.5975 Soluble
213 T H -2.0925 Soluble
214 K H -2.5979 Soluble
215 V H -1.5248 Soluble
216 D H -2.3759 Soluble
217 K H -1.9619 Soluble
218 R H -2.6963 Soluble
219 V H 0.0000 Buried
220 E H -2.9777 Soluble
221 P H -2.1590 Soluble
222 K H -2.4110 Soluble
223 S H -1.2945 Soluble
1 Q L -1.1138 Soluble
2 P L 0.1636 Aggregation-prone
3 V L 1.3155 Aggregation-prone
4 L L 0.0000 Buried
5 T L 0.2070 Aggregation-prone
6 Q L 0.0000 Buried
7 P L -0.5074 Soluble
8 P L -0.7706 Soluble
9 S L -0.9332 Soluble
11 V L -0.3962 Soluble
12 S L -0.2509 Soluble
13 G L 0.0000 Buried
14 A L -0.5035 Soluble
15 P L -0.9419 Soluble
16 G L -1.4951 Soluble
17 Q L -2.1607 Soluble
18 R L -2.5112 Soluble
19 I L 0.0000 Buried
20 T L -0.5295 Soluble
21 I L 0.0000 Buried
22 S L -0.3485 Soluble
23 C L 0.0000 Buried
24 T L -0.1325 Soluble
25 G L -0.1295 Soluble
26 S L -0.3268 Soluble
27 S L -0.6748 Soluble
28 S L -0.4429 Soluble
29 N L 0.0000 Buried
30 I L 0.0000 Buried
31 G L -0.9534 Soluble
35 A L -0.5589 Soluble
36 G L -0.6436 Soluble
37 Y L -0.2534 Soluble
38 D L -0.5950 Soluble
39 V L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.8310 Soluble
44 Q L -0.9355 Soluble
45 L L -0.6889 Soluble
46 P L -0.6008 Soluble
47 G L -0.6419 Soluble
48 T L -0.7522 Soluble
49 A L -0.8460 Soluble
50 P L 0.0000 Buried
51 K L -1.7171 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.2699 Soluble
56 G L -0.3784 Soluble
57 S L 0.0000 Buried
65 S L -0.7409 Soluble
66 S L -0.7333 Soluble
67 R L -1.6554 Soluble
68 N L -1.1942 Soluble
69 S L -0.7914 Soluble
70 G L -0.9296 Soluble
71 V L -0.9702 Soluble
72 P L -1.3623 Soluble
74 D L -2.2153 Soluble
75 R L -1.6742 Soluble
76 F L 0.0000 Buried
77 S L -0.9054 Soluble
78 G L -0.5463 Soluble
79 S L -0.7118 Soluble
80 K L -0.9945 Soluble
83 S L -0.8713 Soluble
84 G L -0.9507 Soluble
85 T L -0.8090 Soluble
86 S L -0.7020 Soluble
87 A L 0.0000 Buried
88 S L -0.4429 Soluble
89 L L 0.0000 Buried
90 A L -0.6024 Soluble
91 I L 0.0000 Buried
92 T L -1.7015 Soluble
93 G L -1.4097 Soluble
94 L L 0.0000 Buried
95 Q L -1.3456 Soluble
96 A L -1.2825 Soluble
97 E L -2.1753 Soluble
98 D L 0.0000 Buried
99 E L 0.0000 Buried
100 A L 0.0000 Buried
101 D L -1.0207 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 S L 0.0000 Buried
107 Y L 0.0899 Aggregation-prone
108 D L 0.0000 Buried
109 S L 0.1770 Aggregation-prone
110 S L 0.5686 Aggregation-prone
112 L L 1.3109 Aggregation-prone
113 S L 0.0101 Aggregation-prone
114 V L 0.1753 Aggregation-prone
115 L L 0.0000 Buried
116 Y L 0.0000 Buried
117 T L 0.0000 Buried
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 T L -0.1165 Soluble
121 G L -0.9095 Soluble
122 T L 0.0000 Buried
123 K L -1.7543 Soluble
124 V L 0.0000 Buried
125 T L -0.4449 Soluble
126 V L 0.0000 Buried
127 L L 0.8796 Aggregation-prone
128 G L -0.2397 Soluble
129 Q L -0.6734 Soluble
130 P L -1.1170 Soluble
131 K L -2.2608 Soluble
132 A L -1.2749 Soluble
133 A L -0.7632 Soluble
134 P L 0.0000 Buried
135 S L -0.5502 Soluble
136 V L 0.0000 Buried
137 T L -0.4615 Soluble
138 L L 0.0000 Buried
139 F L 0.0000 Buried
140 P L -0.1083 Soluble
141 P L -0.4263 Soluble
142 S L 0.0000 Buried
143 S L -1.5693 Soluble
144 E L -2.2529 Soluble
145 E L 0.0000 Buried
146 L L -1.8006 Soluble
147 Q L -2.2321 Soluble
148 A L -1.7491 Soluble
149 N L -2.3906 Soluble
150 K L -2.0739 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.6558 Soluble
159 D L -1.4449 Soluble
160 F L 0.0000 Buried
161 Y L -1.0206 Soluble
162 P L -0.8295 Soluble
163 G L -0.4294 Soluble
164 A L -0.1975 Soluble
165 V L -0.1137 Soluble
166 T L -0.0605 Soluble
167 V L 0.1233 Aggregation-prone
168 A L -0.3710 Soluble
169 W L 0.0000 Buried
170 K L -1.2547 Soluble
171 A L -1.4291 Soluble
172 D L -2.1869 Soluble
173 S L -1.2806 Soluble
174 S L -0.9998 Soluble
175 P L -0.9230 Soluble
176 V L -0.7856 Soluble
177 K L -1.5557 Soluble
178 A L -0.7173 Soluble
179 G L -0.5044 Soluble
180 V L -0.1992 Soluble
181 E L -0.2114 Soluble
182 T L 0.0393 Aggregation-prone
183 T L 0.0073 Aggregation-prone
184 T L -0.1202 Soluble
185 P L -0.2426 Soluble
186 S L -0.4964 Soluble
187 K L -1.0073 Soluble
188 Q L -1.2904 Soluble
189 S L -1.3278 Soluble
190 N L -1.7754 Soluble
191 N L -1.4470 Soluble
192 K L -1.3450 Soluble
193 Y L -0.6988 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.3488 Soluble
201 L L 0.0000 Buried
202 T L -1.6693 Soluble
203 P L -2.3029 Soluble
204 E L -3.1436 Soluble
205 Q L -2.4666 Soluble
206 W L 0.0000 Buried
207 K L -3.1629 Soluble
208 S L -2.4105 Soluble
209 H L -2.6268 Soluble
210 R L -2.7318 Soluble
211 S L -1.7561 Soluble
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -0.9743 Soluble
216 V L 0.0000 Buried
217 T L -0.6689 Soluble
218 H L 0.0000 Buried
219 E L -2.2851 Soluble
220 G L -1.4425 Soluble
221 S L -0.8776 Soluble
222 T L -0.6932 Soluble
223 V L -0.5997 Soluble
224 E L -1.8698 Soluble
225 K L -1.5809 Soluble
226 T L -0.9882 Soluble
227 V L -0.3131 Soluble
228 A L -0.8884 Soluble
229 P L -0.9835 Soluble
230 T L -0.5669 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.606 1.9093 CSV PDB
4.5 -0.6429 1.9093 CSV PDB
5.0 -0.6833 1.9093 CSV PDB
5.5 -0.7194 1.9093 CSV PDB
6.0 -0.7423 1.9093 CSV PDB
6.5 -0.7461 1.9093 CSV PDB
7.0 -0.7325 1.9093 CSV PDB
7.5 -0.7079 1.9093 CSV PDB
8.0 -0.6771 1.9093 CSV PDB
8.5 -0.641 1.9093 CSV PDB
9.0 -0.5997 1.9093 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH