Motavizumab / 4zyp

A4DAB172_4zyp_J_L | Source PDB: 4zyp | Chains: J, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7082
Max Score
2.6765
Min Score
-3.4929
Total Score
-300.29
Score CDR
-0.3514
Score non-CDR
-0.7517

Calculation Parameters

Chain Sequence(s) QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPDIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) J (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4929
Maximum Score 2.6765
Average Score -0.7082
Total Score -300.2909

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q J -1.2671 Soluble
2 V J -0.7156 Soluble
3 T J -0.7048 Soluble
4 L J 0.0000 Buried
5 R J -1.0724 Soluble
6 E J 0.0000 Buried
7 S J -0.3822 Soluble
8 G J -0.2791 Soluble
9 P J -0.1218 Soluble
11 A J 0.1454 Aggregation-prone
12 L J 0.0753 Aggregation-prone
13 V J 0.0000 Buried
14 K J -2.2206 Soluble
15 P J -1.9801 Soluble
16 T J -2.0047 Soluble
17 Q J -2.1631 Soluble
18 T J -1.4541 Soluble
19 L J 0.0000 Buried
20 T J -0.5661 Soluble
21 L J 0.0000 Buried
22 T J -0.2762 Soluble
23 C J 0.0000 Buried
24 T J -0.8947 Soluble
25 F J 0.0000 Buried
26 S J -0.9334 Soluble
27 G J -0.8657 Soluble
28 F J -0.4037 Soluble
29 S J -0.4597 Soluble
30 L J 0.0000 Buried
31 S J -0.7960 Soluble
34 T J -0.2075 Soluble
35 A J 0.0501 Aggregation-prone
36 G J 0.0000 Buried
37 M J 0.0000 Buried
38 S J 0.0000 Buried
39 V J 0.0000 Buried
40 G J 0.0000 Buried
41 W J 0.0000 Buried
42 I J 0.0000 Buried
43 R J 0.0000 Buried
44 Q J -0.8645 Soluble
45 P J -0.9939 Soluble
46 P J -1.1273 Soluble
47 G J -1.4766 Soluble
48 K J -2.1824 Soluble
49 A J -1.2383 Soluble
50 L J 0.0000 Buried
51 E J -0.6780 Soluble
52 W J 0.0000 Buried
53 L J 0.0000 Buried
54 A J 0.0000 Buried
55 D J 0.0000 Buried
56 I J 0.0000 Buried
57 W J 0.0000 Buried
58 W J -1.4387 Soluble
59 D J -2.7644 Soluble
63 D J -3.4929 Soluble
64 K J -3.3276 Soluble
65 K J -2.6075 Soluble
66 H J -1.2359 Soluble
67 Y J -0.6278 Soluble
68 N J -0.8249 Soluble
69 P J -1.1321 Soluble
70 S J -0.9088 Soluble
71 L J -0.8167 Soluble
72 K J -1.8655 Soluble
74 D J -2.3389 Soluble
75 R J -1.8888 Soluble
76 L J 0.0000 Buried
77 T J -0.9510 Soluble
78 I J 0.0000 Buried
79 S J -1.2209 Soluble
80 K J -1.5340 Soluble
81 D J -2.2042 Soluble
82 T J -1.5999 Soluble
83 S J -1.7197 Soluble
84 K J -2.5016 Soluble
85 N J -1.8420 Soluble
86 Q J -1.5033 Soluble
87 V J 0.0000 Buried
88 V J -0.1786 Soluble
89 L J 0.0000 Buried
90 K J -1.0599 Soluble
91 V J 0.0000 Buried
92 T J -1.7958 Soluble
93 N J -2.2714 Soluble
94 M J 0.0000 Buried
95 D J -2.3253 Soluble
96 P J -1.2229 Soluble
97 A J -0.6302 Soluble
98 D J 0.0000 Buried
99 T J -0.3673 Soluble
100 A J 0.0000 Buried
101 T J -0.3374 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 A J 0.0000 Buried
106 R J -0.1222 Soluble
107 D J 0.0000 Buried
108 M J 1.5248 Aggregation-prone
109 I J 2.5648 Aggregation-prone
110 F J 2.6765 Aggregation-prone
112 N J 1.2534 Aggregation-prone
113 F J 1.2240 Aggregation-prone
114 Y J 0.0000 Buried
115 F J 0.0000 Buried
116 D J -0.7812 Soluble
117 V J -0.6018 Soluble
118 W J -0.6451 Soluble
119 G J 0.0000 Buried
120 Q J -1.8025 Soluble
121 G J -1.1891 Soluble
122 T J -0.5166 Soluble
123 T J -0.0870 Soluble
124 V J 0.0000 Buried
125 T J -0.3951 Soluble
126 V J 0.0000 Buried
127 S J -0.9090 Soluble
128 S J -0.7519 Soluble
129 A J -0.6464 Soluble
130 S J -0.7610 Soluble
131 T J -1.0836 Soluble
132 K J -1.9314 Soluble
133 G J -1.7931 Soluble
134 P J 0.0000 Buried
135 S J -0.6285 Soluble
136 V J 0.0000 Buried
137 F J 0.0000 Buried
138 P J -1.1837 Soluble
139 L J 0.0000 Buried
140 A J -0.9899 Soluble
141 P J 0.0000 Buried
142 S J -0.4183 Soluble
143 T J -0.2704 Soluble
144 A J -0.1797 Soluble
145 A J 0.0000 Buried
146 L J 0.0000 Buried
147 G J 0.0000 Buried
148 C J 0.0000 Buried
149 L J 0.0000 Buried
150 V J 0.0000 Buried
151 K J 0.0000 Buried
152 D J -0.8380 Soluble
153 Y J 0.0000 Buried
154 F J 0.0000 Buried
155 P J -1.1149 Soluble
156 E J -1.3199 Soluble
157 P J -1.2419 Soluble
158 V J 0.0000 Buried
159 T J -0.8263 Soluble
160 V J -0.3384 Soluble
161 S J -0.5413 Soluble
162 W J 0.0000 Buried
163 N J -0.9329 Soluble
164 S J -0.7844 Soluble
165 G J -0.6053 Soluble
166 A J -0.3160 Soluble
167 L J -0.1020 Soluble
168 T J -0.2456 Soluble
169 S J -0.2116 Soluble
170 G J -0.2641 Soluble
171 V J 0.0746 Aggregation-prone
172 H J -0.4154 Soluble
173 T J -0.2221 Soluble
174 F J 0.0000 Buried
175 P J -0.2631 Soluble
176 A J 0.0658 Aggregation-prone
177 V J 0.5241 Aggregation-prone
178 L J 0.8831 Aggregation-prone
179 Q J 0.0431 Aggregation-prone
180 S J -0.2085 Soluble
181 S J -0.3489 Soluble
182 G J -0.2605 Soluble
183 L J 0.0000 Buried
184 Y J 0.1739 Aggregation-prone
185 S J 0.0000 Buried
186 L J 0.0000 Buried
187 S J 0.0000 Buried
188 S J 0.0000 Buried
189 V J 0.0000 Buried
190 V J 0.0000 Buried
191 T J -0.1588 Soluble
192 V J 0.0000 Buried
193 P J -0.4943 Soluble
194 S J -0.4687 Soluble
195 S J -0.5276 Soluble
196 S J -0.5612 Soluble
197 L J -0.7909 Soluble
198 G J -1.0911 Soluble
199 T J -0.6693 Soluble
200 Q J -1.1754 Soluble
201 T J -1.2055 Soluble
202 Y J 0.0000 Buried
203 I J -1.4893 Soluble
204 C J 0.0000 Buried
205 N J -1.8659 Soluble
206 V J 0.0000 Buried
207 N J -2.4635 Soluble
208 H J 0.0000 Buried
209 K J -3.0446 Soluble
210 P J -1.9308 Soluble
211 S J -2.1074 Soluble
212 N J -2.7849 Soluble
213 T J -2.5204 Soluble
214 K J -3.0339 Soluble
215 V J -2.0786 Soluble
216 D J -2.8653 Soluble
217 K J -2.4497 Soluble
218 K J -2.7234 Soluble
219 V J 0.0000 Buried
220 E J -2.5406 Soluble
221 P J -1.2193 Soluble
1 D L -2.0085 Soluble
2 I L -1.5137 Soluble
3 Q L -1.6482 Soluble
4 M L -0.8619 Soluble
5 T L -0.5917 Soluble
6 Q L 0.0000 Buried
7 S L -0.4931 Soluble
8 P L -0.4380 Soluble
9 S L -0.5983 Soluble
10 T L -0.3650 Soluble
11 L L -0.1007 Soluble
12 S L 0.0000 Buried
13 A L 0.0000 Buried
14 S L -0.8227 Soluble
15 V L 0.4694 Aggregation-prone
16 G L -1.0671 Soluble
17 D L -2.5593 Soluble
18 R L -2.7200 Soluble
19 V L 0.0000 Buried
20 T L -0.7178 Soluble
21 I L 0.0000 Buried
22 T L -0.5194 Soluble
23 C L 0.0000 Buried
24 S L -1.0659 Soluble
25 A L -1.1238 Soluble
26 S L -1.3145 Soluble
27 S L -1.6311 Soluble
28 R L -2.0969 Soluble
29 V L -0.9511 Soluble
37 G L -0.3626 Soluble
38 Y L 0.6563 Aggregation-prone
39 M L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.3603 Soluble
46 P L -1.1434 Soluble
47 G L -1.6613 Soluble
48 K L -2.5584 Soluble
49 A L -1.7353 Soluble
50 P L 0.0000 Buried
51 K L -1.6542 Soluble
52 L L -0.6267 Soluble
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.3444 Soluble
56 D L -0.4995 Soluble
57 T L 0.0000 Buried
65 S L -0.8890 Soluble
66 K L -1.5700 Soluble
67 L L -0.3725 Soluble
68 A L -0.5002 Soluble
69 S L -0.4481 Soluble
70 G L -0.3866 Soluble
71 V L -0.1763 Soluble
72 P L -0.2288 Soluble
74 S L -0.3086 Soluble
75 R L -0.4808 Soluble
76 F L 0.0000 Buried
77 S L -0.5402 Soluble
78 G L -0.6755 Soluble
79 S L -0.8143 Soluble
80 G L -0.9246 Soluble
83 S L -1.0285 Soluble
84 G L -1.2948 Soluble
85 T L -1.5158 Soluble
86 E L -1.9454 Soluble
87 F L 0.0000 Buried
88 T L -0.6258 Soluble
89 L L 0.0000 Buried
90 T L -0.5873 Soluble
91 I L 0.0000 Buried
92 S L -1.4342 Soluble
93 S L -1.3809 Soluble
94 L L 0.0000 Buried
95 Q L -1.2034 Soluble
96 P L -0.9003 Soluble
97 D L -2.0249 Soluble
98 D L 0.0000 Buried
99 F L -0.4322 Soluble
100 A L 0.0000 Buried
101 T L -0.3352 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 F L 0.0000 Buried
106 Q L 0.0000 Buried
107 G L 0.1817 Aggregation-prone
108 S L -0.1214 Soluble
109 G L -0.3372 Soluble
114 Y L -0.2075 Soluble
115 P L -0.6507 Soluble
116 F L 0.0000 Buried
117 T L -0.6790 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -1.0564 Soluble
121 G L -0.8146 Soluble
122 T L 0.0000 Buried
123 K L -0.6965 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.2767 Soluble
127 K L -1.5913 Soluble
128 R L -1.9043 Soluble
129 T L -0.3075 Soluble
130 V L 0.9216 Aggregation-prone
131 A L 0.3742 Aggregation-prone
132 A L 0.0850 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.1501 Soluble
135 V L 0.0000 Buried
136 F L 0.0727 Aggregation-prone
137 I L 0.0833 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.6107 Soluble
140 P L 0.0000 Buried
141 S L -1.6651 Soluble
142 D L -3.0337 Soluble
143 E L -3.1661 Soluble
144 Q L 0.0000 Buried
145 L L -2.3134 Soluble
146 K L -2.9144 Soluble
147 S L -1.8567 Soluble
148 G L -1.3546 Soluble
149 T L -1.1209 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.6968 Soluble
159 F L 0.0000 Buried
160 Y L -0.5572 Soluble
161 P L -1.2354 Soluble
162 R L -1.9592 Soluble
163 E L -2.8779 Soluble
164 A L -2.2706 Soluble
165 K L -2.5538 Soluble
166 V L 0.0000 Buried
167 Q L -0.9716 Soluble
168 W L 0.0000 Buried
169 K L -0.6562 Soluble
170 V L 0.0000 Buried
171 D L -2.0174 Soluble
172 N L -1.5750 Soluble
173 A L -0.3334 Soluble
174 L L 0.6334 Aggregation-prone
175 Q L -0.1916 Soluble
176 S L -0.4291 Soluble
177 G L -0.8495 Soluble
178 N L -0.6973 Soluble
179 S L -1.0253 Soluble
180 Q L -1.1479 Soluble
181 E L -1.4672 Soluble
182 S L -0.4113 Soluble
183 V L -0.4047 Soluble
184 T L 0.0000 Buried
185 E L -2.0203 Soluble
186 Q L -1.8704 Soluble
187 D L -2.1235 Soluble
188 S L -1.8467 Soluble
189 K L -2.5227 Soluble
190 D L -2.2416 Soluble
191 S L -1.3910 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.5328 Soluble
199 L L 0.0000 Buried
200 T L -0.4002 Soluble
201 L L -0.5802 Soluble
202 S L -1.1918 Soluble
203 K L -2.0471 Soluble
204 A L -1.7733 Soluble
205 D L -2.4120 Soluble
206 Y L 0.0000 Buried
207 E L -3.1628 Soluble
208 K L -3.4600 Soluble
209 H L -2.9283 Soluble
210 K L -3.2121 Soluble
211 V L -1.7947 Soluble
212 Y L 0.0000 Buried
213 A L -0.8421 Soluble
214 C L 0.0000 Buried
215 E L -1.0874 Soluble
216 V L 0.0000 Buried
217 T L -1.3347 Soluble
218 H L 0.0000 Buried
219 Q L -1.6434 Soluble
220 G L -0.3196 Soluble
221 L L -0.3431 Soluble
222 S L -0.4362 Soluble
223 S L -0.3893 Soluble
224 P L -0.4969 Soluble
225 V L 0.0308 Aggregation-prone
226 T L -0.5584 Soluble
227 K L -0.8390 Soluble
228 S L -0.8138 Soluble
229 F L -1.0083 Soluble
230 N L -2.1211 Soluble
231 R L -2.3529 Soluble
232 G L -1.4298 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6576 5.4766 CSV PDB
4.5 -0.7035 5.4766 CSV PDB
5.0 -0.7558 5.4766 CSV PDB
5.5 -0.8044 5.4766 CSV PDB
6.0 -0.8381 5.4766 CSV PDB
6.5 -0.8487 5.4766 CSV PDB
7.0 -0.837 5.4766 CSV PDB
7.5 -0.8108 5.4766 CSV PDB
8.0 -0.776 5.4766 CSV PDB
8.5 -0.7336 5.4766 CSV PDB
9.0 -0.6825 5.4766 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH