Tixagevimab / 7l7d

A4DAB270_7l7d_H_L | Source PDB: 7l7d | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7296
Max Score
1.8163
Min Score
-3.6482
Total Score
-316.63
Score CDR
-0.3179
Score non-CDR
-0.7856

Calculation Parameters

Chain Sequence(s) QMQLVQSGPEVKKPGTSVKVSCKASGFTFMSSAVQWVRQARGQRLEWIGWIVIGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPYCSSISCNDGFDIWGQGTMVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHYGSSRGWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6482
Maximum Score 1.8163
Average Score -0.7296
Total Score -316.6306

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.2535 Soluble
2 M H -0.3936 Soluble
3 Q H -1.0878 Soluble
4 L H 0.0000 Buried
5 V H -0.3453 Soluble
6 Q H 0.0000 Buried
7 S H -0.7462 Soluble
8 G H -0.7181 Soluble
9 P H -0.2883 Soluble
11 E H -0.4606 Soluble
12 V H 0.4693 Aggregation-prone
13 K H -1.0232 Soluble
14 K H -2.1680 Soluble
15 P H -1.7169 Soluble
16 G H -1.4260 Soluble
17 T H -1.1077 Soluble
18 S H -1.2453 Soluble
19 V H 0.0000 Buried
20 K H -1.9099 Soluble
21 V H 0.0000 Buried
22 S H 0.0000 Buried
23 C H 0.0000 Buried
24 K H -1.3270 Soluble
25 A H 0.0000 Buried
26 S H -0.8127 Soluble
27 G H -0.6142 Soluble
28 F H -0.0181 Soluble
29 T H 0.4029 Aggregation-prone
30 F H 0.0000 Buried
35 M H 0.3553 Aggregation-prone
36 S H 0.3111 Aggregation-prone
37 S H 0.0000 Buried
38 A H 0.0994 Aggregation-prone
39 V H 0.0000 Buried
40 Q H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H 0.0000 Buried
45 A H -1.8257 Soluble
46 R H -2.6536 Soluble
47 G H -2.2308 Soluble
48 Q H -2.7339 Soluble
49 R H -2.3800 Soluble
50 L H 0.0000 Buried
51 E H -0.7585 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 W H -0.1762 Soluble
56 I H 0.0000 Buried
57 V H -0.0655 Soluble
58 I H 0.0000 Buried
59 G H -0.4835 Soluble
62 S H -0.7355 Soluble
63 G H -0.9171 Soluble
64 N H -1.3327 Soluble
65 T H -0.7969 Soluble
66 N H -1.0874 Soluble
67 Y H -1.3684 Soluble
68 A H -1.9111 Soluble
69 Q H -2.8250 Soluble
70 K H -2.7945 Soluble
71 F H 0.0000 Buried
72 Q H -2.5035 Soluble
74 E H -2.7666 Soluble
75 R H -1.6683 Soluble
76 V H 0.0000 Buried
77 T H -0.7584 Soluble
78 I H 0.0000 Buried
79 T H -0.4081 Soluble
80 R H -0.7910 Soluble
81 D H -1.0499 Soluble
82 M H -0.1780 Soluble
83 S H -0.3008 Soluble
84 T H -0.6250 Soluble
85 S H -0.6072 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.5409 Soluble
89 M H 0.0000 Buried
90 E H -1.2209 Soluble
91 L H 0.0000 Buried
92 S H -1.1449 Soluble
93 S H -1.1939 Soluble
94 L H 0.0000 Buried
95 R H -2.6630 Soluble
96 S H -2.1803 Soluble
97 E H -2.4139 Soluble
98 D H 0.0000 Buried
99 T H -0.9681 Soluble
100 A H 0.0000 Buried
101 V H -0.0341 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 A H 0.0000 Buried
107 P H -0.5676 Soluble
108 Y H -0.2261 Soluble
109 C H 0.0000 Buried
110 S H 0.5327 Aggregation-prone
111 S H 0.7710 Aggregation-prone
111A I H 1.8163 Aggregation-prone
112B S H 0.4677 Aggregation-prone
112A C H -0.1876 Soluble
112 N H -1.4374 Soluble
113 D H -1.9930 Soluble
114 G H 0.0000 Buried
115 F H 0.0000 Buried
116 D H -1.0008 Soluble
117 I H 0.0000 Buried
118 W H -0.4544 Soluble
119 G H 0.0000 Buried
120 Q H -1.2298 Soluble
121 G H -0.5333 Soluble
122 T H 0.0000 Buried
123 M H 0.3245 Aggregation-prone
124 V H 0.0000 Buried
125 T H -0.3852 Soluble
126 V H 0.0000 Buried
127 S H -1.1458 Soluble
128 S H -0.8452 Soluble
129 A H -0.5308 Soluble
130 S H -0.5637 Soluble
131 T H -0.5455 Soluble
132 K H -1.2501 Soluble
133 G H -1.3610 Soluble
134 P H -0.5882 Soluble
135 S H -0.3312 Soluble
136 V H 0.0000 Buried
137 F H -0.5404 Soluble
138 P H 0.0000 Buried
139 L H 0.0000 Buried
140 A H -1.0877 Soluble
141 P H 0.0000 Buried
142 S H -0.7844 Soluble
143 G H -0.6560 Soluble
144 T H -0.4985 Soluble
145 A H -0.2719 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.5360 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H -0.4375 Soluble
157 E H -0.5996 Soluble
158 P H -0.7688 Soluble
159 V H -0.6411 Soluble
160 T H -0.4881 Soluble
161 V H -0.0825 Soluble
162 S H -0.2841 Soluble
163 W H 0.0000 Buried
164 N H -0.6569 Soluble
165 S H -0.5864 Soluble
166 G H -0.3824 Soluble
167 A H -0.1866 Soluble
168 L H 0.0313 Aggregation-prone
169 T H -0.1543 Soluble
170 S H -0.1843 Soluble
171 G H -0.2042 Soluble
172 V H 0.1687 Aggregation-prone
173 H H -0.3184 Soluble
174 T H 0.0067 Aggregation-prone
175 F H 0.0000 Buried
176 P H -0.5938 Soluble
177 A H 0.1041 Aggregation-prone
178 V H 0.3071 Aggregation-prone
179 L H 0.9006 Aggregation-prone
180 Q H -0.0087 Soluble
181 S H -0.1145 Soluble
182 S H -0.2708 Soluble
183 G H -0.0623 Soluble
184 L H -0.0548 Soluble
185 Y H 0.0000 Buried
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1358 Soluble
193 V H 0.0000 Buried
194 P H -0.5244 Soluble
195 S H -0.5678 Soluble
196 S H -0.6417 Soluble
197 S H -0.6726 Soluble
198 L H -0.8605 Soluble
199 G H -0.9876 Soluble
200 T H -0.7345 Soluble
201 Q H -1.2103 Soluble
202 T H -1.0571 Soluble
203 Y H 0.0000 Buried
204 I H -1.1518 Soluble
205 C H 0.0000 Buried
206 N H 0.0000 Buried
207 V H 0.0000 Buried
208 N H -1.7785 Soluble
209 H H 0.0000 Buried
210 K H -2.7185 Soluble
211 P H -1.6876 Soluble
212 S H -1.8767 Soluble
213 N H -2.5581 Soluble
214 T H -2.0406 Soluble
215 K H -2.5938 Soluble
216 V H -1.6285 Soluble
217 D H -2.3856 Soluble
218 K H -1.9676 Soluble
219 K H -2.2517 Soluble
220 V H 0.0000 Buried
221 E H -2.7704 Soluble
222 P H -2.0831 Soluble
223 K H -2.3532 Soluble
224 S H -1.2960 Soluble
1 E L -1.7979 Soluble
2 I L -0.3664 Soluble
3 V L 0.3054 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.6637 Soluble
6 Q L 0.0000 Buried
7 S L -0.7057 Soluble
8 P L -0.4649 Soluble
9 G L -0.7663 Soluble
10 T L -0.4088 Soluble
11 L L -0.2048 Soluble
12 S L -0.5228 Soluble
13 L L -0.8175 Soluble
14 S L -1.3310 Soluble
15 P L -1.7230 Soluble
16 G L -2.0381 Soluble
17 E L -2.5126 Soluble
18 R L -2.9826 Soluble
19 A L 0.0000 Buried
20 T L -0.5780 Soluble
21 L L 0.0000 Buried
22 S L -0.7837 Soluble
23 C L 0.0000 Buried
24 R L -2.0360 Soluble
25 A L -1.0489 Soluble
26 S L -1.0303 Soluble
27 Q L -1.6525 Soluble
28 S L -1.1903 Soluble
29 V L -0.4361 Soluble
30 S L -0.2359 Soluble
36 S L -0.3102 Soluble
37 S L -0.2164 Soluble
38 Y L 0.3408 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.2922 Soluble
46 P L -1.4171 Soluble
47 G L -1.2939 Soluble
48 Q L -1.4916 Soluble
49 A L -1.0227 Soluble
50 P L 0.0000 Buried
51 R L -0.9556 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.6098 Soluble
56 G L -0.5038 Soluble
57 A L 0.0000 Buried
65 S L -0.7246 Soluble
66 S L -0.9741 Soluble
67 R L -1.5825 Soluble
68 A L 0.0000 Buried
69 T L -0.6174 Soluble
70 G L -0.8462 Soluble
71 I L -0.9525 Soluble
72 P L -1.2555 Soluble
74 D L -2.1996 Soluble
75 R L -1.9983 Soluble
76 F L 0.0000 Buried
77 S L -0.9373 Soluble
78 G L -0.5752 Soluble
79 S L -0.7232 Soluble
80 G L -1.1124 Soluble
83 S L -1.0689 Soluble
84 G L -1.1498 Soluble
85 T L -1.6540 Soluble
86 D L -2.0700 Soluble
87 F L 0.0000 Buried
88 T L -0.7369 Soluble
89 L L 0.0000 Buried
90 T L -0.8282 Soluble
91 I L 0.0000 Buried
92 S L -2.4045 Soluble
93 R L -3.2544 Soluble
94 L L 0.0000 Buried
95 E L -2.2281 Soluble
96 P L -1.4254 Soluble
97 E L -1.9514 Soluble
98 D L 0.0000 Buried
99 F L -0.5505 Soluble
100 A L 0.0000 Buried
101 V L -0.2231 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 H L 0.0000 Buried
107 Y L 0.0000 Buried
108 G L 0.0000 Buried
109 S L -0.6435 Soluble
113 S L -1.1549 Soluble
114 R L -2.1769 Soluble
115 G L -1.6828 Soluble
116 W L 0.0000 Buried
117 T L -0.3230 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.3877 Soluble
121 G L -1.0509 Soluble
122 T L 0.0000 Buried
123 K L -0.5136 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.6155 Soluble
127 K L -1.3118 Soluble
128 R L -1.0113 Soluble
129 T L -0.0668 Soluble
130 V L 0.5262 Aggregation-prone
131 A L 0.0836 Aggregation-prone
132 A L -0.2015 Soluble
133 P L 0.0000 Buried
134 S L -0.1172 Soluble
135 V L 0.0000 Buried
136 F L 0.2598 Aggregation-prone
137 I L 0.2264 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5106 Soluble
140 P L 0.0000 Buried
141 S L -1.4041 Soluble
142 D L -2.7335 Soluble
143 E L -2.4147 Soluble
144 Q L 0.0000 Buried
145 L L -1.8513 Soluble
146 K L -2.6498 Soluble
147 S L -1.6063 Soluble
148 G L -1.2389 Soluble
149 T L -0.9574 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.7962 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.5754 Soluble
162 R L -2.8561 Soluble
163 E L -3.1227 Soluble
164 A L -2.2848 Soluble
165 K L -2.4393 Soluble
166 V L -1.2148 Soluble
167 Q L -0.6979 Soluble
168 W L 0.0000 Buried
169 K L -0.5612 Soluble
170 V L 0.0000 Buried
171 D L -1.6842 Soluble
172 N L -1.4563 Soluble
173 A L -0.1704 Soluble
174 L L 0.7399 Aggregation-prone
175 Q L -0.3767 Soluble
176 S L -0.6090 Soluble
177 G L -1.3762 Soluble
178 N L -1.7891 Soluble
179 S L -1.6378 Soluble
180 Q L -1.6788 Soluble
181 E L -2.0070 Soluble
182 S L -1.0768 Soluble
183 V L -0.9074 Soluble
184 T L -1.1995 Soluble
185 E L -2.2831 Soluble
186 Q L -1.8754 Soluble
187 D L -1.9292 Soluble
188 S L -1.7058 Soluble
189 K L -2.2161 Soluble
190 D L -1.6197 Soluble
191 S L -1.6638 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7885 Soluble
199 L L 0.0000 Buried
200 T L -0.8058 Soluble
201 L L 0.0000 Buried
202 S L -1.2304 Soluble
203 K L -2.0072 Soluble
204 A L -1.8682 Soluble
205 D L -2.6365 Soluble
206 Y L 0.0000 Buried
207 E L -3.6474 Soluble
208 K L -3.6482 Soluble
209 H L -3.1802 Soluble
210 K L -3.3749 Soluble
211 V L -1.6706 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7524 Soluble
216 V L 0.0000 Buried
217 T L -1.4919 Soluble
218 H L 0.0000 Buried
219 Q L -1.9700 Soluble
220 G L -0.6405 Soluble
221 L L -0.9517 Soluble
222 R L -2.0899 Soluble
223 S L -1.2112 Soluble
224 P L -1.0368 Soluble
225 V L -0.2991 Soluble
226 T L -0.4502 Soluble
227 K L -0.5778 Soluble
228 S L -0.4570 Soluble
229 F L -0.9262 Soluble
230 N L -2.0161 Soluble
231 R L -2.7090 Soluble
232 G L -2.3759 Soluble
233 E L -2.5568 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.8095 2.0325 CSV PDB
4.5 -0.8499 1.9902 CSV PDB
5.0 -0.8985 1.9333 CSV PDB
5.5 -0.9457 1.8721 CSV PDB
6.0 -0.98 1.8235 CSV PDB
6.5 -0.992 1.8235 CSV PDB
7.0 -0.9809 1.8235 CSV PDB
7.5 -0.9537 1.8235 CSV PDB
8.0 -0.9174 1.8235 CSV PDB
8.5 -0.8751 1.8235 CSV PDB
9.0 -0.8277 1.8235 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH