Ociperlimab / 8jen

Calculation Parameters

Chain Sequence(s)	`EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYYMYWVRQAPGKGLEWVAYITKGGGSTYYPDSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARQTNYDFTMDYWGQGTLVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCEIVMTQSPATLSVSPGERATLSCKASQDVGTSVAWYQQKPGQAPRLLIYWASARHTGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYSSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC` input.pdb
Selected Chain(s)	C (Heavy), D (Light)
Distance of Aggregation	10 Å
FoldX Energy Minimization	Yes
pH Calculations	Yes
Downloads	Download all data (.tar.gz)

Aggrescan4D Profile

Chain: Show buried residues (score = 0)

Aggregation-prone (score > 0)

Soluble (score < 0)

Buried (score = 0)

Per-Residue A4D Scores

Download CSV

Minimum Score -3.3387

Maximum Score 1.2154

Average Score -0.6952

Total Score -299.6213

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Classification:

Index	Residue	Chain	A4D Score	Classification
1	E	C	-2.0173	Soluble
2	V	C	-1.0185	Soluble
3	Q	C	-0.9840	Soluble
4	L	C	0.0000	Buried
5	V	C	0.9327	Aggregation-prone
6	E	C	0.0000	Buried
7	S	C	-0.2702	Soluble
8	G	C	-0.8807	Soluble
9	G	C	-0.4705	Soluble
11	G	C	-0.2552	Soluble
12	L	C	-0.0165	Soluble
13	V	C	-0.6004	Soluble
14	Q	C	-1.5554	Soluble
15	P	C	-1.6848	Soluble
16	G	C	-1.4728	Soluble
17	G	C	-1.1857	Soluble
18	S	C	-1.3722	Soluble
19	L	C	-1.1712	Soluble
20	R	C	-2.0294	Soluble
21	L	C	0.0000	Buried
22	S	C	-0.3868	Soluble
23	C	C	0.0000	Buried
24	A	C	-0.0605	Soluble
25	A	C	0.0000	Buried
26	S	C	-0.7564	Soluble
27	G	C	-1.1422	Soluble
28	F	C	-0.7446	Soluble
29	T	C	-0.7437	Soluble
30	F	C	0.0000	Buried
35	S	C	-1.6785	Soluble
36	D	C	-2.2575	Soluble
37	Y	C	-1.2014	Soluble
38	Y	C	-0.4687	Soluble
39	M	C	0.0000	Buried
40	Y	C	0.0000	Buried
41	W	C	0.0000	Buried
42	V	C	0.0000	Buried
43	R	C	0.0000	Buried
44	Q	C	-0.8154	Soluble
45	A	C	-1.1743	Soluble
46	P	C	-0.9772	Soluble
47	G	C	-1.4846	Soluble
48	K	C	-2.2879	Soluble
49	G	C	-1.4186	Soluble
50	L	C	0.0000	Buried
51	E	C	-0.9792	Soluble
52	W	C	0.0000	Buried
53	V	C	0.0000	Buried
54	A	C	0.0000	Buried
55	Y	C	0.0000	Buried
56	I	C	0.0000	Buried
57	T	C	-0.8274	Soluble
58	K	C	-1.7833	Soluble
59	G	C	-1.6821	Soluble
62	G	C	-1.2216	Soluble
63	G	C	-0.9569	Soluble
64	S	C	-0.4233	Soluble
65	T	C	0.2859	Aggregation-prone
66	Y	C	0.7125	Aggregation-prone
67	Y	C	-0.3956	Soluble
68	P	C	-1.3956	Soluble
69	D	C	-2.4227	Soluble
70	S	C	-1.5090	Soluble
71	V	C	0.0000	Buried
72	K	C	-2.4789	Soluble
74	G	C	-1.7957	Soluble
75	R	C	-1.5422	Soluble
76	F	C	0.0000	Buried
77	T	C	-0.7801	Soluble
78	I	C	0.0000	Buried
79	S	C	-0.6542	Soluble
80	R	C	-1.3823	Soluble
81	D	C	-1.9335	Soluble
82	N	C	-2.2253	Soluble
83	A	C	-1.5309	Soluble
84	K	C	-2.3969	Soluble
85	N	C	-1.8507	Soluble
86	T	C	-1.0821	Soluble
87	L	C	0.0000	Buried
88	Y	C	-0.6483	Soluble
89	L	C	0.0000	Buried
90	Q	C	-1.2808	Soluble
91	M	C	0.0000	Buried
92	N	C	-1.6172	Soluble
93	S	C	-1.3508	Soluble
94	L	C	0.0000	Buried
95	R	C	-2.2993	Soluble
96	A	C	-1.7337	Soluble
97	E	C	-2.2115	Soluble
98	D	C	0.0000	Buried
99	T	C	-0.6944	Soluble
100	A	C	0.0000	Buried
101	V	C	0.2354	Aggregation-prone
102	Y	C	0.0000	Buried
103	Y	C	0.0000	Buried
104	C	C	0.0000	Buried
105	A	C	0.0000	Buried
106	R	C	0.0000	Buried
107	Q	C	0.0000	Buried
108	T	C	0.0000	Buried
109	N	C	-0.6949	Soluble
110	Y	C	0.8870	Aggregation-prone
112	D	C	0.7666	Aggregation-prone
113	F	C	1.2154	Aggregation-prone
114	T	C	0.0000	Buried
115	M	C	0.0000	Buried
116	D	C	0.0000	Buried
117	Y	C	0.1413	Aggregation-prone
118	W	C	-0.1573	Soluble
119	G	C	0.0000	Buried
120	Q	C	-1.1058	Soluble
121	G	C	0.0000	Buried
122	T	C	0.0183	Aggregation-prone
123	L	C	0.1108	Aggregation-prone
124	V	C	0.0000	Buried
125	T	C	-0.3891	Soluble
126	V	C	0.0000	Buried
127	S	C	-0.9437	Soluble
128	S	C	-0.6776	Soluble
129	A	C	-0.5402	Soluble
130	S	C	-0.7385	Soluble
131	T	C	-0.9854	Soluble
132	K	C	-1.9450	Soluble
133	G	C	-1.6828	Soluble
134	P	C	-0.6571	Soluble
135	S	C	-0.2626	Soluble
136	V	C	-0.1504	Soluble
137	F	C	-0.4607	Soluble
138	P	C	-0.8603	Soluble
139	L	C	0.0000	Buried
140	A	C	-1.0320	Soluble
141	P	C	0.0000	Buried
142	S	C	-0.6471	Soluble
143	S	C	-0.2998	Soluble
144	G	C	-0.6471	Soluble
145	T	C	-0.4854	Soluble
146	A	C	0.0000	Buried
147	A	C	0.0000	Buried
148	L	C	0.0000	Buried
149	G	C	0.0000	Buried
150	C	C	0.0000	Buried
151	L	C	0.0000	Buried
152	V	C	0.0000	Buried
153	K	C	0.0000	Buried
154	D	C	-0.5993	Soluble
155	Y	C	0.0000	Buried
156	F	C	0.0000	Buried
157	P	C	0.0000	Buried
158	E	C	-0.6315	Soluble
159	P	C	-0.6798	Soluble
160	V	C	-0.6483	Soluble
161	T	C	-0.5136	Soluble
162	V	C	-0.3901	Soluble
163	S	C	-0.3395	Soluble
164	W	C	0.0000	Buried
165	N	C	-0.7221	Soluble
166	S	C	-0.6356	Soluble
167	G	C	-0.5562	Soluble
168	A	C	-0.2650	Soluble
169	L	C	-0.0682	Soluble
170	T	C	-0.2312	Soluble
171	S	C	-0.2459	Soluble
172	G	C	-0.3285	Soluble
173	V	C	0.0545	Aggregation-prone
174	H	C	-0.2937	Soluble
175	T	C	0.0207	Aggregation-prone
176	F	C	0.0000	Buried
177	P	C	-0.2878	Soluble
178	A	C	0.1929	Aggregation-prone
179	V	C	0.4508	Aggregation-prone
180	L	C	1.1995	Aggregation-prone
181	Q	C	0.1285	Aggregation-prone
182	S	C	-0.2361	Soluble
183	S	C	-0.2230	Soluble
184	G	C	-0.0205	Soluble
185	L	C	-0.0310	Soluble
186	Y	C	0.3123	Aggregation-prone
187	S	C	0.0000	Buried
188	L	C	0.0000	Buried
189	S	C	0.0000	Buried
190	S	C	0.0000	Buried
191	V	C	0.0000	Buried
192	V	C	0.0000	Buried
193	T	C	-0.1786	Soluble
194	V	C	0.0000	Buried
195	P	C	-0.4853	Soluble
196	S	C	-0.5529	Soluble
197	S	C	-0.6175	Soluble
198	S	C	-0.6283	Soluble
199	L	C	-0.8463	Soluble
200	G	C	-1.0140	Soluble
201	T	C	-0.7633	Soluble
202	Q	C	-1.3192	Soluble
203	T	C	-1.1528	Soluble
204	Y	C	0.0000	Buried
205	I	C	-1.0583	Soluble
206	C	C	0.0000	Buried
207	N	C	0.0000	Buried
208	V	C	0.0000	Buried
209	N	C	-1.6741	Soluble
210	H	C	0.0000	Buried
211	K	C	-2.7724	Soluble
212	P	C	-1.6894	Soluble
213	S	C	-2.0368	Soluble
214	N	C	-2.5927	Soluble
215	T	C	-2.0006	Soluble
216	K	C	-2.3019	Soluble
217	V	C	-0.9124	Soluble
218	D	C	-2.1534	Soluble
219	K	C	-1.8545	Soluble
220	K	C	-2.4710	Soluble
221	V	C	0.0000	Buried
222	E	C	-2.8711	Soluble
223	P	C	-1.8730	Soluble
224	K	C	-2.0175	Soluble
225	S	C	-0.8894	Soluble
226	C	C	0.0816	Aggregation-prone
1	E	D	-1.4885	Soluble
2	I	D	0.0000	Buried
3	V	D	0.6652	Aggregation-prone
4	M	D	0.0000	Buried
5	T	D	-0.5882	Soluble
6	Q	D	-0.6272	Soluble
7	S	D	-0.7294	Soluble
8	P	D	-0.4321	Soluble
9	A	D	-0.4132	Soluble
10	T	D	-0.3960	Soluble
11	L	D	-0.2748	Soluble
12	S	D	-0.5410	Soluble
13	V	D	0.0000	Buried
14	S	D	-1.6858	Soluble
15	P	D	-1.9780	Soluble
16	G	D	-1.9641	Soluble
17	E	D	-2.9216	Soluble
18	R	D	-2.8627	Soluble
19	A	D	0.0000	Buried
20	T	D	-0.7374	Soluble
21	L	D	0.0000	Buried
22	S	D	-0.8894	Soluble
23	C	D	0.0000	Buried
24	K	D	-2.4991	Soluble
25	A	D	0.0000	Buried
26	S	D	-1.3375	Soluble
27	Q	D	-2.3749	Soluble
28	D	D	-2.9029	Soluble
29	V	D	0.0000	Buried
36	G	D	-1.0691	Soluble
37	T	D	-0.3244	Soluble
38	S	D	0.0767	Aggregation-prone
39	V	D	0.0000	Buried
40	A	D	0.0000	Buried
41	W	D	0.0000	Buried
42	Y	D	0.0000	Buried
43	Q	D	0.0000	Buried
44	Q	D	0.0000	Buried
45	K	D	-1.4744	Soluble
46	P	D	-1.1144	Soluble
47	G	D	-1.4334	Soluble
48	Q	D	-1.8573	Soluble
49	A	D	-1.2302	Soluble
50	P	D	0.0000	Buried
51	R	D	-1.3016	Soluble
52	L	D	0.0000	Buried
53	L	D	0.0000	Buried
54	I	D	0.0000	Buried
55	Y	D	0.6528	Aggregation-prone
56	W	D	1.0476	Aggregation-prone
57	A	D	0.0000	Buried
65	S	D	-0.2485	Soluble
66	A	D	-0.0911	Soluble
67	R	D	-0.9555	Soluble
68	H	D	0.0000	Buried
69	T	D	-0.5424	Soluble
70	G	D	-0.6617	Soluble
71	I	D	0.0000	Buried
72	P	D	-0.4566	Soluble
74	A	D	-0.4166	Soluble
75	R	D	-0.7034	Soluble
76	F	D	0.0000	Buried
77	S	D	-0.4989	Soluble
78	G	D	-0.3255	Soluble
79	S	D	-0.5145	Soluble
80	G	D	-1.0429	Soluble
83	S	D	-1.0873	Soluble
84	G	D	-1.8606	Soluble
85	T	D	-2.3460	Soluble
86	E	D	-2.6340	Soluble
87	F	D	0.0000	Buried
88	T	D	-0.8281	Soluble
89	L	D	0.0000	Buried
90	T	D	-0.6067	Soluble
91	I	D	0.0000	Buried
92	S	D	-1.5575	Soluble
93	S	D	-1.7578	Soluble
94	L	D	0.0000	Buried
95	Q	D	-1.7271	Soluble
96	S	D	-2.0786	Soluble
97	E	D	-2.4267	Soluble
98	D	D	0.0000	Buried
99	F	D	-1.0461	Soluble
100	A	D	0.0000	Buried
101	V	D	-0.3866	Soluble
102	Y	D	0.0000	Buried
103	Y	D	0.0000	Buried
104	C	D	0.0000	Buried
105	Q	D	0.0000	Buried
106	Q	D	0.0000	Buried
107	Y	D	0.0000	Buried
108	S	D	-0.2753	Soluble
109	S	D	-0.4035	Soluble
114	Y	D	0.2017	Aggregation-prone
115	P	D	-0.4251	Soluble
116	L	D	0.0000	Buried
117	T	D	-0.0229	Soluble
118	F	D	0.1416	Aggregation-prone
119	G	D	0.0000	Buried
120	G	D	-0.7585	Soluble
121	G	D	-0.7518	Soluble
122	T	D	0.0000	Buried
123	K	D	-1.0203	Soluble
124	V	D	0.0000	Buried
125	E	D	0.0000	Buried
126	I	D	0.0000	Buried
127	K	D	-1.1411	Soluble
128	R	D	-0.8003	Soluble
129	T	D	0.1517	Aggregation-prone
130	V	D	0.8401	Aggregation-prone
131	A	D	0.3424	Aggregation-prone
132	A	D	-0.0734	Soluble
133	P	D	0.0000	Buried
134	S	D	-0.2001	Soluble
135	V	D	0.0000	Buried
136	F	D	-0.0233	Soluble
137	I	D	-0.0459	Soluble
138	F	D	0.0000	Buried
139	P	D	-0.5599	Soluble
140	P	D	0.0000	Buried
141	S	D	-1.3243	Soluble
142	D	D	-2.5257	Soluble
143	E	D	-2.2315	Soluble
144	Q	D	0.0000	Buried
145	L	D	-1.9430	Soluble
146	K	D	-2.6363	Soluble
147	S	D	-1.7416	Soluble
148	G	D	-1.4497	Soluble
149	T	D	-1.0657	Soluble
150	A	D	0.0000	Buried
151	S	D	0.0000	Buried
152	V	D	0.0000	Buried
153	V	D	0.0000	Buried
154	C	D	0.0000	Buried
155	L	D	0.0000	Buried
156	L	D	0.0000	Buried
157	N	D	-0.4148	Soluble
158	N	D	-0.9431	Soluble
159	F	D	0.0000	Buried
160	Y	D	0.0000	Buried
161	P	D	-1.6460	Soluble
162	R	D	-2.8823	Soluble
163	E	D	-3.2810	Soluble
164	A	D	-2.3147	Soluble
165	K	D	-2.2271	Soluble
166	V	D	-0.9801	Soluble
167	Q	D	-0.4255	Soluble
168	W	D	0.0000	Buried
169	K	D	-0.5653	Soluble
170	V	D	0.0000	Buried
171	D	D	-2.1004	Soluble
172	N	D	-1.6229	Soluble
173	A	D	-0.2979	Soluble
174	L	D	0.7738	Aggregation-prone
175	Q	D	-0.4494	Soluble
176	S	D	-0.6489	Soluble
177	G	D	-1.3711	Soluble
178	N	D	-1.8060	Soluble
179	S	D	-1.6123	Soluble
180	Q	D	-1.6050	Soluble
181	E	D	-2.1213	Soluble
182	S	D	0.0000	Buried
183	V	D	-0.7621	Soluble
184	T	D	-0.9612	Soluble
185	E	D	-1.8269	Soluble
186	Q	D	0.0000	Buried
187	D	D	-1.8519	Soluble
188	S	D	-2.0276	Soluble
189	K	D	-2.4909	Soluble
190	D	D	-1.8012	Soluble
191	S	D	-1.7920	Soluble
192	T	D	0.0000	Buried
193	Y	D	0.0000	Buried
194	S	D	0.0000	Buried
195	L	D	0.0000	Buried
196	S	D	0.0000	Buried
197	S	D	0.0000	Buried
198	T	D	-0.7362	Soluble
199	L	D	0.0000	Buried
200	T	D	-0.6735	Soluble
201	L	D	-0.7972	Soluble
202	S	D	-0.9907	Soluble
203	K	D	-1.9788	Soluble
204	A	D	-1.6442	Soluble
205	D	D	-2.1532	Soluble
206	Y	D	0.0000	Buried
207	E	D	-3.1334	Soluble
208	K	D	-3.3361	Soluble
209	H	D	-3.0693	Soluble
210	K	D	-3.3387	Soluble
211	V	D	-1.8072	Soluble
212	Y	D	0.0000	Buried
213	A	D	0.0000	Buried
214	C	D	0.0000	Buried
215	E	D	-0.7956	Soluble
216	V	D	0.0000	Buried
217	T	D	-1.1737	Soluble
218	H	D	0.0000	Buried
219	Q	D	-1.5578	Soluble
220	G	D	-0.3914	Soluble
221	L	D	-0.2639	Soluble
222	S	D	-0.4866	Soluble
223	S	D	-0.4466	Soluble
224	P	D	-0.5146	Soluble
225	V	D	-0.0831	Soluble
226	T	D	-0.6190	Soluble
227	K	D	-1.1353	Soluble
228	S	D	-0.8013	Soluble
229	F	D	-1.0277	Soluble
230	N	D	-1.9679	Soluble
231	R	D	-2.4793	Soluble
232	G	D	-2.0166	Soluble
233	E	D	-2.0683	Soluble
234	C	D	-0.5720	Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer | colored by A4D score

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Downloads

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Color Legend (B-factor = A4D Score)

Score > 1.5 — highly aggregation-prone

Score 0.5–1.5 — aggregation-prone

Score ≈ 0 — buried

Score −1 to −0.5 — soluble

Score < −2.5 — highly soluble

pH Structure

Load structure at specific pH condition

A4D Score Threshold

Highlight residues > threshold in the sequence panel

Threshold: 0.0

CDR Regions

Outline CDR regions in sequence panel

HCDR1

HCDR2

HCDR3

LCDR1

LCDR2

LCDR3

Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH	Avg A4D Score	Max A4D Score	Downloads
4.0	-0.6505	2.8859	CSV PDB
4.5	-0.6935	2.8583	CSV PDB
5.0	-0.745	2.8291	CSV PDB
5.5	-0.7947	2.7994	CSV PDB
6.0	-0.8309	2.7696	CSV PDB
6.5	-0.8433	2.7418	CSV PDB
7.0	-0.8303	2.73	CSV PDB
7.5	-0.8	2.7187	CSV PDB
8.0	-0.7603	2.7084	CSV PDB
8.5	-0.7144	2.7004	CSV PDB
9.0	-0.6626	2.6951	CSV PDB