Diridavumab / 4evn

A4DAB087_4evn_E_F | Source PDB: 4evn | Chains: E, F | Done
96.55
Yes
10 Å
Yes
Avg A4D Score
-0.6583
Max Score
3.1359
Min Score
-3.1995
Total Score
-285.69
Score CDR
-0.0138
Score non-CDR
-0.7479

Calculation Parameters

Chain Sequence(s) QVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAYVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE input.pdb
Selected Chain(s) E (Heavy), F (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1995
Maximum Score 3.1359
Average Score -0.6583
Total Score -285.6946

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q E -1.3933 Soluble
2 V E -0.8499 Soluble
3 Q E -1.2782 Soluble
4 L E 0.0000 Buried
5 V E 0.4654 Aggregation-prone
6 E E -0.1759 Soluble
7 S E -0.5310 Soluble
8 G E -0.5161 Soluble
9 A E -0.4952 Soluble
11 E E -0.8219 Soluble
12 V E -0.3741 Soluble
13 K E -1.4881 Soluble
14 K E -2.3413 Soluble
15 P E -2.2921 Soluble
16 G E -1.6294 Soluble
17 S E -1.2697 Soluble
18 S E -1.1942 Soluble
19 V E 0.0000 Buried
20 K E -2.0507 Soluble
21 V E 0.0000 Buried
22 S E -0.6469 Soluble
23 C E 0.0000 Buried
24 K E -1.0611 Soluble
25 A E 0.0000 Buried
26 S E -0.7764 Soluble
27 G E -0.9010 Soluble
28 G E -0.4789 Soluble
29 P E 0.3255 Aggregation-prone
30 F E 1.9432 Aggregation-prone
35 R E 0.0000 Buried
36 S E 0.8736 Aggregation-prone
37 Y E 0.9439 Aggregation-prone
38 A E 0.0000 Buried
39 I E 0.0000 Buried
40 S E 0.0000 Buried
41 W E 0.0000 Buried
42 V E 0.0000 Buried
43 R E -0.3764 Soluble
44 Q E -0.5900 Soluble
45 A E -0.9167 Soluble
46 P E -0.7521 Soluble
47 G E -1.0832 Soluble
48 Q E -1.3577 Soluble
49 G E -0.9577 Soluble
50 P E -0.5970 Soluble
51 E E -0.6195 Soluble
52 W E 0.0000 Buried
53 M E 0.0000 Buried
54 G E 0.0000 Buried
55 G E 0.0000 Buried
56 I E 0.0000 Buried
57 I E 0.0000 Buried
58 P E 0.0000 Buried
59 I E 3.1359 Aggregation-prone
62 F E 2.7474 Aggregation-prone
63 G E 1.1848 Aggregation-prone
64 T E 0.5176 Aggregation-prone
65 T E -0.2292 Soluble
66 K E -0.8392 Soluble
67 Y E -0.8962 Soluble
68 A E 0.0000 Buried
69 P E -1.2999 Soluble
70 K E -2.2453 Soluble
71 F E 0.0000 Buried
72 Q E -2.1722 Soluble
74 G E -1.5392 Soluble
75 R E -1.4742 Soluble
76 V E 0.0000 Buried
77 T E -0.8916 Soluble
78 I E 0.0000 Buried
79 T E -0.3455 Soluble
80 A E -0.0636 Soluble
81 D E -0.0940 Soluble
82 D E 0.7052 Aggregation-prone
83 F E 1.8216 Aggregation-prone
84 A E 0.5708 Aggregation-prone
85 G E 0.0000 Buried
86 T E -0.1654 Soluble
87 V E 0.0000 Buried
88 Y E -0.6437 Soluble
89 M E 0.0000 Buried
90 E E -1.4398 Soluble
91 L E 0.0000 Buried
92 S E -1.1953 Soluble
93 S E -1.2511 Soluble
94 L E 0.0000 Buried
95 R E -3.1117 Soluble
96 S E -2.3975 Soluble
97 E E -2.5499 Soluble
98 D E 0.0000 Buried
99 T E -1.0240 Soluble
100 A E 0.0000 Buried
101 M E -0.0788 Soluble
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 A E 0.0000 Buried
106 K E 0.0010 Aggregation-prone
107 H E 0.0000 Buried
108 M E 0.2184 Aggregation-prone
109 G E 0.1535 Aggregation-prone
110 Y E 0.9358 Aggregation-prone
111 Q E -0.5645 Soluble
112A V E 0.0000 Buried
112 R E -1.9076 Soluble
113 E E -1.3505 Soluble
114 T E -0.6515 Soluble
115 M E 0.0000 Buried
116 D E -0.3454 Soluble
117 V E -0.1634 Soluble
118 W E -0.4142 Soluble
119 G E 0.0000 Buried
120 K E -1.4729 Soluble
121 G E -0.7430 Soluble
122 T E 0.0000 Buried
123 T E -0.1355 Soluble
124 V E 0.0000 Buried
125 T E -0.8190 Soluble
126 V E 0.0000 Buried
127 S E -1.2765 Soluble
128 S E -1.1450 Soluble
129 A E -0.7696 Soluble
130 S E -0.8349 Soluble
131 T E -0.7681 Soluble
132 K E -1.4609 Soluble
133 G E -1.4874 Soluble
134 P E -0.7270 Soluble
135 S E -0.3514 Soluble
136 V E 0.0000 Buried
137 F E 0.0000 Buried
138 P E -0.9740 Soluble
139 L E 0.0000 Buried
140 A E -0.9203 Soluble
141 P E 0.0000 Buried
142 S E -1.1024 Soluble
143 S E -1.2658 Soluble
144 K E -2.0439 Soluble
145 S E -1.2081 Soluble
146 T E -1.0849 Soluble
147 S E -0.9362 Soluble
148 G E -0.9028 Soluble
149 G E -0.8806 Soluble
150 T E -0.6112 Soluble
151 A E 0.0000 Buried
152 A E -0.2896 Soluble
153 L E 0.0000 Buried
154 G E 0.0000 Buried
155 C E 0.0000 Buried
156 L E 0.0000 Buried
157 V E 0.0000 Buried
158 K E -0.4006 Soluble
159 D E -0.6298 Soluble
160 Y E 0.0000 Buried
161 F E 0.0000 Buried
162 P E 0.0000 Buried
163 E E -0.7756 Soluble
164 P E -0.8399 Soluble
165 V E -0.6738 Soluble
166 T E -0.6133 Soluble
167 V E -0.3840 Soluble
168 S E -0.3931 Soluble
169 W E 0.0000 Buried
170 N E -0.8345 Soluble
171 S E -0.7109 Soluble
172 G E -0.5375 Soluble
173 A E -0.2095 Soluble
174 L E 0.0905 Aggregation-prone
175 T E -0.1252 Soluble
176 S E -0.2451 Soluble
177 G E -0.3113 Soluble
178 V E 0.1491 Aggregation-prone
179 H E -0.2084 Soluble
180 T E -0.0556 Soluble
181 F E 0.0000 Buried
182 P E -0.2749 Soluble
183 A E -0.0146 Soluble
184 V E 0.0000 Buried
185 L E 0.9000 Aggregation-prone
186 Q E 0.0511 Aggregation-prone
187 S E -0.2127 Soluble
188 S E -0.2454 Soluble
189 G E -0.0535 Soluble
190 L E -0.0773 Soluble
191 Y E 0.1393 Aggregation-prone
192 S E 0.0000 Buried
193 L E 0.0000 Buried
194 S E 0.0000 Buried
195 S E 0.0000 Buried
196 V E 0.0000 Buried
197 V E 0.0000 Buried
198 T E -0.2052 Soluble
199 V E 0.0000 Buried
200 P E -0.6136 Soluble
201 S E -0.6273 Soluble
202 S E -0.6293 Soluble
203 S E -0.6070 Soluble
204 L E -0.8439 Soluble
205 G E -1.0901 Soluble
206 T E -0.7211 Soluble
207 Q E -1.2829 Soluble
208 T E -1.1571 Soluble
209 Y E 0.0000 Buried
210 I E -1.3847 Soluble
211 C E 0.0000 Buried
212 N E -1.5916 Soluble
213 V E 0.0000 Buried
214 N E -1.8935 Soluble
215 H E 0.0000 Buried
216 K E -2.7786 Soluble
217 P E -1.6993 Soluble
218 S E -1.8898 Soluble
219 N E -2.6054 Soluble
220 T E -2.0659 Soluble
221 K E -2.6433 Soluble
222 V E -1.4881 Soluble
223 D E -2.6347 Soluble
224 K E -2.1979 Soluble
225 R E -2.7808 Soluble
226 V E 0.0000 Buried
227 E E -2.5700 Soluble
228 P E -1.2577 Soluble
3 V F 1.6170 Aggregation-prone
4 L F 0.0000 Buried
5 T F 0.0746 Aggregation-prone
6 Q F 0.0000 Buried
7 P F -0.5276 Soluble
8 P F -0.7720 Soluble
9 S F -0.7467 Soluble
11 V F -0.2727 Soluble
12 S F -0.1227 Soluble
13 A F -0.3606 Soluble
14 A F -0.6048 Soluble
15 P F -1.3453 Soluble
16 G F -2.0059 Soluble
17 Q F -2.6188 Soluble
18 K F -2.5988 Soluble
19 V F 0.0000 Buried
20 T F -0.4730 Soluble
21 I F 0.0000 Buried
22 S F -0.2913 Soluble
23 C F 0.0000 Buried
24 S F -0.1572 Soluble
25 G F -0.0544 Soluble
26 S F -0.3835 Soluble
27 S F -0.8717 Soluble
28 S F -0.5206 Soluble
29 N F 0.0000 Buried
30 I F 0.0000 Buried
35 G F -1.0060 Soluble
36 N F -1.2569 Soluble
37 N F 0.0000 Buried
38 Y F 0.1288 Aggregation-prone
39 V F 0.0000 Buried
40 S F 0.0000 Buried
41 W F 0.0000 Buried
42 Y F 0.0000 Buried
43 Q F 0.0000 Buried
44 Q F -0.7178 Soluble
45 L F -0.4077 Soluble
46 P F -0.5998 Soluble
47 G F -0.8060 Soluble
48 T F -0.8946 Soluble
49 A F -0.9971 Soluble
50 P F 0.0000 Buried
51 K F -1.0718 Soluble
52 L F 0.0000 Buried
53 L F 0.0000 Buried
54 I F 0.0000 Buried
55 Y F -1.2518 Soluble
56 D F -1.6117 Soluble
57 N F -1.5450 Soluble
65 N F -2.6097 Soluble
66 K F -2.9494 Soluble
67 R F -2.4123 Soluble
68 P F -1.1674 Soluble
69 S F -0.9528 Soluble
70 G F -0.8363 Soluble
71 I F -0.9127 Soluble
72 P F -1.3060 Soluble
74 D F -2.2211 Soluble
75 R F -1.5461 Soluble
76 F F 0.0000 Buried
77 S F -1.5165 Soluble
78 G F -1.5064 Soluble
79 S F -1.3677 Soluble
80 K F -1.0704 Soluble
83 S F -0.7954 Soluble
84 G F -1.0061 Soluble
85 T F -0.8541 Soluble
86 S F -0.6457 Soluble
87 A F 0.0000 Buried
88 T F -0.5516 Soluble
89 L F 0.0000 Buried
90 G F 0.0000 Buried
91 I F 0.0000 Buried
92 T F -1.9606 Soluble
93 G F -1.9030 Soluble
94 L F 0.0000 Buried
95 Q F -1.8838 Soluble
96 T F -1.0063 Soluble
97 G F -0.9775 Soluble
98 D F 0.0000 Buried
99 E F -0.7947 Soluble
100 A F 0.0000 Buried
101 D F -1.0762 Soluble
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 G F 0.0000 Buried
106 T F 0.0000 Buried
107 W F 0.0000 Buried
108 D F 0.0000 Buried
109 S F -0.3283 Soluble
110 S F 0.5327 Aggregation-prone
112 L F 1.4197 Aggregation-prone
113 S F 0.4461 Aggregation-prone
114 A F 0.1736 Aggregation-prone
115 Y F -0.0706 Soluble
116 V F 0.0000 Buried
117 V F 0.0000 Buried
118 F F 0.0000 Buried
119 G F 0.0000 Buried
120 G F -0.5861 Soluble
121 G F -0.9819 Soluble
122 T F 0.0000 Buried
123 K F -1.4136 Soluble
124 L F 0.0000 Buried
125 T F -0.1525 Soluble
126 V F 0.0000 Buried
127 L F 1.0157 Aggregation-prone
128 G F -0.3983 Soluble
129 Q F -1.3090 Soluble
130 P F -1.5422 Soluble
131 K F -2.6456 Soluble
132 A F -1.9776 Soluble
133 N F -2.0817 Soluble
134 P F 0.0000 Buried
135 T F -0.4352 Soluble
136 V F 0.0000 Buried
137 T F -0.6026 Soluble
138 L F 0.0000 Buried
139 F F 0.0000 Buried
140 P F -0.1605 Soluble
141 P F -0.5371 Soluble
142 S F -0.7944 Soluble
143 S F -1.3075 Soluble
144 E F -1.9320 Soluble
145 E F 0.0000 Buried
146 L F -1.9893 Soluble
147 Q F -2.2601 Soluble
148 A F -1.8899 Soluble
149 N F -2.7810 Soluble
150 K F -2.8708 Soluble
151 A F 0.0000 Buried
152 T F 0.0000 Buried
153 L F 0.0000 Buried
154 V F 0.0000 Buried
155 C F 0.0000 Buried
156 L F 0.0000 Buried
157 I F 0.0000 Buried
158 S F -0.6764 Soluble
159 D F -1.4665 Soluble
160 F F 0.0000 Buried
161 Y F -1.6655 Soluble
162 P F -1.2892 Soluble
163 G F -1.0226 Soluble
164 A F -0.4026 Soluble
165 V F -0.2775 Soluble
166 T F -0.0493 Soluble
167 V F 0.0969 Aggregation-prone
168 A F -0.4082 Soluble
169 W F 0.0000 Buried
170 K F -1.0418 Soluble
171 A F -1.3117 Soluble
172 D F -1.6206 Soluble
173 G F -1.2025 Soluble
174 S F -0.7581 Soluble
175 P F -0.9213 Soluble
176 V F -0.8149 Soluble
177 K F -1.6641 Soluble
178 A F -0.8858 Soluble
179 G F -0.7875 Soluble
180 V F -0.5732 Soluble
181 E F -0.6754 Soluble
182 T F -0.4889 Soluble
183 T F -0.8568 Soluble
184 K F -1.7375 Soluble
185 P F -1.1243 Soluble
186 S F -1.2456 Soluble
187 K F -1.8907 Soluble
188 Q F -1.7703 Soluble
189 S F -1.6336 Soluble
190 N F -2.4078 Soluble
191 N F -2.6361 Soluble
192 K F -2.2870 Soluble
193 Y F -1.2013 Soluble
194 A F 0.0000 Buried
195 A F 0.0000 Buried
196 S F 0.0000 Buried
197 S F 0.0000 Buried
198 Y F 0.0000 Buried
199 L F 0.0000 Buried
200 S F -0.7444 Soluble
201 L F 0.0000 Buried
202 T F -1.9807 Soluble
203 P F -2.5899 Soluble
204 E F -3.1995 Soluble
205 Q F -2.4272 Soluble
206 W F 0.0000 Buried
207 K F -3.0637 Soluble
208 S F -2.4853 Soluble
209 H F -2.3885 Soluble
210 R F -2.8495 Soluble
211 S F -1.8919 Soluble
212 Y F 0.0000 Buried
213 S F 0.0000 Buried
214 C F 0.0000 Buried
215 Q F -0.9339 Soluble
216 V F 0.0000 Buried
217 T F -0.7625 Soluble
218 H F 0.0000 Buried
219 E F -2.4742 Soluble
220 G F -1.3873 Soluble
221 S F -1.0368 Soluble
222 T F -0.8605 Soluble
223 V F -0.7657 Soluble
224 E F -1.6998 Soluble
225 K F -1.7368 Soluble
226 T F -1.1806 Soluble
227 V F 0.0000 Buried
228 A F -1.5528 Soluble
229 P F -1.6716 Soluble
230 T F -1.2236 Soluble
231 E F -2.1442 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6122 6.1436 CSV PDB
4.5 -0.6423 6.0758 CSV PDB
5.0 -0.6762 6.0029 CSV PDB
5.5 -0.7047 5.9282 CSV PDB
6.0 -0.7172 5.853 CSV PDB
6.5 -0.7055 5.7778 CSV PDB
7.0 -0.6706 5.7035 CSV PDB
7.5 -0.621 5.6402 CSV PDB
8.0 -0.5642 5.6402 CSV PDB
8.5 -0.5031 5.6402 CSV PDB
9.0 -0.4383 5.6402 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH