Diridavumab / 8f38

A4DAB087_8f38_F_I | Source PDB: 8f38 | Chains: F, I | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.4631
Max Score
3.0782
Min Score
-2.8421
Total Score
-105.13
Score CDR
-0.1837
Score non-CDR
-0.5483

Calculation Parameters

Chain Sequence(s) VQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRRPTAYVVFGGGTKLTVL input.pdb
Selected Chain(s) F (Heavy), I (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.8421
Maximum Score 3.0782
Average Score -0.4631
Total Score -105.132

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V F 1.0169 Aggregation-prone
3 Q F -0.4069 Soluble
4 L F 0.0000 Buried
5 V F 0.2722 Aggregation-prone
6 E F -0.2189 Soluble
7 S F -0.6906 Soluble
8 G F -0.5328 Soluble
9 A F -0.1545 Soluble
11 E F 0.0032 Aggregation-prone
12 V F 1.1233 Aggregation-prone
13 K F -0.5506 Soluble
14 K F -1.8045 Soluble
15 P F -1.9205 Soluble
16 G F -1.4066 Soluble
17 S F -1.1130 Soluble
18 S F -1.1726 Soluble
19 V F 0.0000 Buried
20 K F -1.8671 Soluble
21 V F 0.0000 Buried
22 S F -0.3806 Soluble
23 C F 0.0000 Buried
24 K F -0.7820 Soluble
25 A F -0.2492 Soluble
26 S F -0.4278 Soluble
27 G F -0.4598 Soluble
28 G F 0.0687 Aggregation-prone
29 P F 0.4239 Aggregation-prone
30 F F 1.7673 Aggregation-prone
35 R F 0.7083 Aggregation-prone
36 S F 0.7695 Aggregation-prone
37 Y F 0.7974 Aggregation-prone
38 A F 0.0000 Buried
39 I F 0.0000 Buried
40 S F 0.0000 Buried
41 W F 0.0000 Buried
42 V F 0.0000 Buried
43 R F 0.0000 Buried
44 Q F 0.0000 Buried
45 A F -0.9620 Soluble
46 P F -0.8485 Soluble
47 G F -1.2097 Soluble
48 Q F -1.7273 Soluble
49 G F -1.1548 Soluble
50 P F 0.0000 Buried
51 E F -0.7803 Soluble
52 W F 0.0000 Buried
53 M F 0.0000 Buried
54 G F 0.0000 Buried
55 G F 0.0000 Buried
56 I F 0.0000 Buried
57 I F 0.8613 Aggregation-prone
58 P F 0.0000 Buried
59 I F 3.0782 Aggregation-prone
62 F F 2.8277 Aggregation-prone
63 G F 1.0867 Aggregation-prone
64 T F 0.4188 Aggregation-prone
65 T F -0.1662 Soluble
66 K F -0.7327 Soluble
67 Y F -0.8251 Soluble
68 A F 0.0000 Buried
69 P F -1.5868 Soluble
70 K F -2.3039 Soluble
71 F F 0.0000 Buried
72 Q F -2.1481 Soluble
74 G F -1.4834 Soluble
75 R F -1.3002 Soluble
76 V F 0.0000 Buried
77 T F -0.7960 Soluble
78 I F 0.0000 Buried
79 T F -0.4121 Soluble
80 A F -0.5634 Soluble
81 D F -0.9720 Soluble
82 D F 0.0528 Aggregation-prone
83 F F 1.4521 Aggregation-prone
84 A F 0.3357 Aggregation-prone
85 G F -0.2405 Soluble
86 T F 0.0000 Buried
87 V F 0.0000 Buried
88 Y F -0.3124 Soluble
89 M F 0.0000 Buried
90 E F -1.4341 Soluble
91 L F 0.0000 Buried
92 S F -1.0401 Soluble
93 S F -0.9968 Soluble
94 L F 0.0000 Buried
95 R F -2.2483 Soluble
96 S F -1.7900 Soluble
97 E F -2.2088 Soluble
98 D F 0.0000 Buried
99 T F -0.4916 Soluble
100 A F 0.0000 Buried
101 M F -0.0092 Soluble
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 A F 0.0000 Buried
106 K F 0.0828 Aggregation-prone
107 H F 0.0000 Buried
108 M F 0.4957 Aggregation-prone
109 G F 0.2838 Aggregation-prone
110 Y F 0.9687 Aggregation-prone
111 Q F -0.4743 Soluble
112A V F 0.0000 Buried
112 R F -0.4971 Soluble
113 E F 0.0000 Buried
114 T F -0.2633 Soluble
115 M F 0.0000 Buried
116 D F -0.8084 Soluble
117 V F -0.1432 Soluble
118 W F -0.4307 Soluble
119 G F 0.0000 Buried
120 K F -1.5777 Soluble
121 G F 0.0000 Buried
122 T F -0.4175 Soluble
123 T F 0.0937 Aggregation-prone
124 V F 0.0000 Buried
125 T F 0.0237 Aggregation-prone
126 V F -0.3934 Soluble
3 V I 1.6243 Aggregation-prone
4 L I 0.0000 Buried
5 T I -0.0210 Soluble
6 Q I -0.3822 Soluble
7 P I -0.5439 Soluble
8 P I -0.7100 Soluble
9 S I -0.6781 Soluble
11 V I -0.1699 Soluble
12 S I -0.0420 Soluble
13 A I -0.2066 Soluble
14 A I -0.3273 Soluble
15 P I -1.0202 Soluble
16 G I -1.7385 Soluble
17 Q I -2.2324 Soluble
18 K I -2.4062 Soluble
19 V I 0.0000 Buried
20 T I -0.5084 Soluble
21 I I 0.0000 Buried
22 S I -0.3743 Soluble
23 C I 0.0000 Buried
24 S I -0.2842 Soluble
25 G I -0.0226 Soluble
26 S I -0.4001 Soluble
27 S I -0.9468 Soluble
28 S I -1.2054 Soluble
29 N I 0.0000 Buried
30 I I 0.0000 Buried
35 G I -1.2060 Soluble
36 N I -1.5997 Soluble
37 D I -0.7466 Soluble
38 Y I 0.0294 Aggregation-prone
39 V I 0.0000 Buried
40 S I 0.0000 Buried
41 W I 0.0000 Buried
42 Y I 0.0000 Buried
43 Q I -0.8267 Soluble
44 Q I -0.8350 Soluble
45 L I -0.4057 Soluble
46 P I -0.4468 Soluble
47 G I -0.7003 Soluble
48 T I -0.7933 Soluble
49 A I -0.8415 Soluble
50 P I 0.0000 Buried
51 K I -1.6375 Soluble
52 L I 0.0000 Buried
53 L I 0.0000 Buried
54 I I 0.0000 Buried
55 Y I -1.4041 Soluble
56 D I -1.8652 Soluble
57 N I -1.7313 Soluble
65 N I -2.6279 Soluble
66 K I -2.8421 Soluble
67 R I -2.3722 Soluble
68 P I -1.0293 Soluble
69 S I -0.7552 Soluble
70 G I -0.8528 Soluble
71 I I -1.0212 Soluble
72 P I -1.3233 Soluble
74 D I -2.2068 Soluble
75 R I -1.5503 Soluble
76 F I 0.0000 Buried
77 S I -1.4741 Soluble
78 G I -1.3877 Soluble
79 S I -1.3620 Soluble
80 K I -1.0661 Soluble
83 S I -0.8391 Soluble
84 G I -1.0439 Soluble
85 T I -0.9398 Soluble
86 S I -0.7433 Soluble
87 A I 0.0000 Buried
88 T I -0.4975 Soluble
89 L I 0.0000 Buried
90 G I -0.6919 Soluble
91 I I 0.0000 Buried
92 T I -1.7648 Soluble
93 G I -1.4511 Soluble
94 L I 0.0000 Buried
95 Q I -1.6761 Soluble
96 T I -0.9426 Soluble
97 G I -1.1120 Soluble
98 D I 0.0000 Buried
99 E I -1.3728 Soluble
100 A I 0.0000 Buried
101 N I -0.8821 Soluble
102 Y I 0.0000 Buried
103 Y I 0.0000 Buried
104 C I 0.0000 Buried
105 A I 0.0000 Buried
106 T I 0.0000 Buried
107 W I -0.4515 Soluble
108 D I -0.9692 Soluble
109 R I -2.2550 Soluble
110 R I -2.5246 Soluble
112 P I -1.4453 Soluble
113 T I -1.0640 Soluble
114 A I -1.1245 Soluble
115 Y I -0.3352 Soluble
116 V I 0.0000 Buried
117 V I 0.5060 Aggregation-prone
118 F I 0.3726 Aggregation-prone
119 G I 0.0806 Aggregation-prone
120 G I -0.4924 Soluble
121 G I -0.9255 Soluble
122 T I 0.0000 Buried
123 K I -1.3564 Soluble
124 L I 0.0000 Buried
125 T I -0.2312 Soluble
126 V I 0.0910 Aggregation-prone
127 L I 1.3022 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.298 5.8152 CSV PDB
4.5 -0.3246 5.8152 CSV PDB
5.0 -0.3554 5.8152 CSV PDB
5.5 -0.384 5.8152 CSV PDB
6.0 -0.4025 5.8152 CSV PDB
6.5 -0.4035 5.8152 CSV PDB
7.0 -0.3865 5.8152 CSV PDB
7.5 -0.3575 5.8152 CSV PDB
8.0 -0.3222 5.8152 CSV PDB
8.5 -0.2823 5.8152 CSV PDB
9.0 -0.2374 5.815 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH