Zinlirvimab / 7ugq

A4DAB308_7ugq_N_Q | Source PDB: 7ugq | Chains: N, Q | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5479
Max Score
2.3229
Min Score
-3.7036
Total Score
-129.84
Score CDR
-0.3274
Score non-CDR
-0.6259

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) N (Heavy), Q (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7036
Maximum Score 2.3229
Average Score -0.5479
Total Score -129.8422

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q N -1.8922 Soluble
2 V N 0.0000 Buried
3 Q N -2.1346 Soluble
4 L N 0.0000 Buried
5 Q N -1.9523 Soluble
6 E N 0.0000 Buried
7 S N -0.7286 Soluble
8 G N -0.3934 Soluble
9 P N -0.0375 Soluble
11 G N 0.4796 Aggregation-prone
12 L N 1.2936 Aggregation-prone
13 V N 0.0000 Buried
14 K N -0.7520 Soluble
15 P N -0.9886 Soluble
16 S N -1.1884 Soluble
17 E N -1.6879 Soluble
18 T N -1.3664 Soluble
19 L N 0.0000 Buried
20 S N -0.9882 Soluble
21 V N 0.0000 Buried
22 T N -0.6679 Soluble
23 C N 0.0000 Buried
24 S N -1.2451 Soluble
25 V N 0.0000 Buried
26 S N -1.7259 Soluble
27 G N -1.8415 Soluble
28 D N -2.3785 Soluble
29 S N -1.5724 Soluble
30 M N 0.0000 Buried
35 N N -2.3881 Soluble
36 N N -2.4640 Soluble
37 Y N -1.4516 Soluble
38 Y N -0.9133 Soluble
39 W N 0.0000 Buried
40 T N 0.0000 Buried
41 W N 0.0000 Buried
42 I N 0.0000 Buried
43 R N -0.6523 Soluble
44 Q N 0.0000 Buried
45 S N -1.0785 Soluble
46 P N -1.1259 Soluble
47 G N -1.4508 Soluble
48 K N -2.2301 Soluble
49 G N -1.4373 Soluble
50 L N 0.0000 Buried
51 E N -1.0970 Soluble
52 W N 0.0000 Buried
53 I N 0.0000 Buried
54 G N 0.0000 Buried
55 Y N 0.0792 Aggregation-prone
56 I N 0.0000 Buried
57 S N 0.0000 Buried
58 D N -3.7036 Soluble
59 R N -3.5971 Soluble
63 E N -3.3229 Soluble
64 S N -1.7939 Soluble
65 A N -0.5441 Soluble
66 T N -0.0809 Soluble
67 Y N -0.1435 Soluble
68 N N 0.0000 Buried
69 P N -0.6389 Soluble
70 S N -0.6125 Soluble
71 L N -0.9090 Soluble
72 N N -1.8272 Soluble
74 S N -1.4227 Soluble
75 R N -2.0951 Soluble
76 V N -0.9130 Soluble
77 V N -0.0582 Soluble
78 I N 0.0000 Buried
79 S N -0.8059 Soluble
80 R N -1.7470 Soluble
81 D N -2.2484 Soluble
82 T N -1.8152 Soluble
83 S N -1.7437 Soluble
84 K N -2.5003 Soluble
85 N N -2.1444 Soluble
86 Q N -1.6745 Soluble
87 L N 0.0000 Buried
88 S N -0.7738 Soluble
89 L N 0.0000 Buried
90 K N -1.2954 Soluble
91 L N 0.0000 Buried
92 N N -1.6602 Soluble
93 S N -1.4396 Soluble
94 V N 0.0000 Buried
95 T N -0.7003 Soluble
96 P N -0.6324 Soluble
97 A N -0.2386 Soluble
98 D N -0.4268 Soluble
99 T N -0.0590 Soluble
100 A N 0.0000 Buried
101 V N -0.2155 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 A N 0.0000 Buried
106 T N 0.0000 Buried
107 A N 0.0000 Buried
108 R N -1.5214 Soluble
109 R N -1.8800 Soluble
110 G N -1.1110 Soluble
111 Q N -0.5003 Soluble
111A R N 0.1102 Aggregation-prone
111B I N 1.6478 Aggregation-prone
111C Y N 1.4900 Aggregation-prone
111D G N 1.2758 Aggregation-prone
111E V N 2.0865 Aggregation-prone
111F V N 2.3229 Aggregation-prone
112G S N 1.3910 Aggregation-prone
112F F N 2.0976 Aggregation-prone
112E G N 1.1319 Aggregation-prone
112D E N 0.9692 Aggregation-prone
112C F N 1.3294 Aggregation-prone
112B F N 0.3686 Aggregation-prone
112A Y N 0.0929 Aggregation-prone
112 Y N -0.1646 Soluble
113 Y N 0.0000 Buried
114 S N 0.0000 Buried
115 M N 0.0000 Buried
116 D N -0.2444 Soluble
117 V N -0.0957 Soluble
118 W N 0.0000 Buried
119 G N 0.0000 Buried
120 K N -2.3102 Soluble
121 G N 0.0000 Buried
122 T N -0.6961 Soluble
123 T N -0.1515 Soluble
124 V N 0.0000 Buried
125 T N 0.3408 Aggregation-prone
126 V N 0.2350 Aggregation-prone
127 S N 0.0642 Aggregation-prone
128 S N -0.1511 Soluble
129 A N 0.0592 Aggregation-prone
11 L Q 0.9982 Aggregation-prone
12 S Q 0.6751 Aggregation-prone
13 V Q 0.0000 Buried
14 A Q 0.2951 Aggregation-prone
15 L Q 0.2544 Aggregation-prone
16 G Q -1.1407 Soluble
17 E Q -1.7556 Soluble
18 T Q -1.5763 Soluble
19 A Q 0.0000 Buried
20 R Q -1.7535 Soluble
21 I Q 0.0000 Buried
22 S Q -1.0995 Soluble
23 C Q -0.8901 Soluble
24 G Q -1.1614 Soluble
25 R Q -1.5320 Soluble
26 Q Q -1.6765 Soluble
27 A Q 0.0000 Buried
28 L Q 0.2940 Aggregation-prone
29 G Q -0.0782 Soluble
36 S Q 0.4510 Aggregation-prone
37 R Q 0.0000 Buried
38 A Q 0.0000 Buried
39 V Q 0.0000 Buried
40 Q Q 0.0000 Buried
41 W Q 0.0000 Buried
42 Y Q 0.0000 Buried
43 Q Q 0.0000 Buried
44 H Q 0.0000 Buried
45 R Q -1.7164 Soluble
46 P Q -1.5991 Soluble
47 G Q -1.5964 Soluble
48 Q Q -2.1036 Soluble
49 A Q -1.3629 Soluble
50 P Q 0.0000 Buried
51 I Q 0.4450 Aggregation-prone
52 L Q 0.0000 Buried
53 L Q 0.0000 Buried
54 I Q 0.0000 Buried
55 Y Q -0.4397 Soluble
56 N Q -0.7687 Soluble
57 N Q 0.0000 Buried
65 Q Q -1.8696 Soluble
66 D Q -1.6522 Soluble
67 R Q -1.8434 Soluble
68 P Q -0.9447 Soluble
69 S Q -0.7718 Soluble
70 G Q -0.5799 Soluble
71 I Q -0.8015 Soluble
72 P Q -1.4047 Soluble
74 E Q -2.2120 Soluble
75 R Q -1.6087 Soluble
76 F Q 0.0000 Buried
77 S Q -1.4739 Soluble
78 G Q -1.3434 Soluble
79 T Q -0.8022 Soluble
80 P Q -0.7792 Soluble
81 D Q -0.1102 Soluble
81A I Q 1.5588 Aggregation-prone
82 N Q 0.3831 Aggregation-prone
83 F Q 1.3638 Aggregation-prone
84 G Q -0.0319 Soluble
85 T Q -0.4771 Soluble
86 R Q -2.0787 Soluble
87 A Q 0.0000 Buried
88 T Q 0.0000 Buried
89 L Q 0.0000 Buried
90 T Q -1.0356 Soluble
91 I Q 0.0000 Buried
92 S Q -1.6528 Soluble
93 G Q -1.3757 Soluble
94 V Q 0.0000 Buried
95 E Q -2.2971 Soluble
96 A Q -1.1973 Soluble
97 G Q -1.5398 Soluble
98 D Q 0.0000 Buried
99 E Q -2.6165 Soluble
100 A Q 0.0000 Buried
101 D Q 0.0000 Buried
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 H Q 0.0000 Buried
106 M Q 0.0000 Buried
107 W Q 0.0000 Buried
108 D Q 0.0000 Buried
109 S Q -0.4562 Soluble
110 R Q -1.6954 Soluble
112 S Q -0.9233 Soluble
113 G Q -0.5435 Soluble
114 F Q 0.5764 Aggregation-prone
115 S Q 0.2597 Aggregation-prone
116 W Q 0.0273 Aggregation-prone
117 S Q -0.4005 Soluble
118 F Q 0.0000 Buried
119 G Q -0.8145 Soluble
120 G Q -1.1584 Soluble
121 A Q -1.0079 Soluble
122 T Q -0.8990 Soluble
123 R Q -2.0193 Soluble
124 L Q 0.0000 Buried
125 T Q -0.3716 Soluble
126 V Q -0.1195 Soluble
127 L Q 1.0809 Aggregation-prone
128 G Q 0.2294 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3941 4.3029 CSV PDB
4.5 -0.4294 4.2782 CSV PDB
5.0 -0.4735 4.241 CSV PDB
5.5 -0.52 4.1974 CSV PDB
6.0 -0.5613 4.1542 CSV PDB
6.5 -0.5909 4.1185 CSV PDB
7.0 -0.6062 4.0957 CSV PDB
7.5 -0.6106 4.085 CSV PDB
8.0 -0.6085 4.081 CSV PDB
8.5 -0.6015 4.0796 CSV PDB
9.0 -0.5896 4.0792 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH