Zinlirvimab / 7ugo

A4DAB308_7ugo_O_R | Source PDB: 7ugo | Chains: O, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5464
Max Score
3.0177
Min Score
-3.626
Total Score
-129.5
Score CDR
-0.2569
Score non-CDR
-0.649

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) O (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.626
Maximum Score 3.0177
Average Score -0.5464
Total Score -129.5025

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.8347 Soluble
2 V O -1.5321 Soluble
3 Q O -2.0339 Soluble
4 L O 0.0000 Buried
5 Q O -1.5930 Soluble
6 E O 0.0000 Buried
7 S O -0.6583 Soluble
8 G O -0.3922 Soluble
9 P O -0.0156 Soluble
11 G O 0.4833 Aggregation-prone
12 L O 1.1021 Aggregation-prone
13 V O -0.2934 Soluble
14 K O -1.7652 Soluble
15 P O -1.4981 Soluble
16 S O -1.6909 Soluble
17 E O -2.2768 Soluble
18 T O -1.5680 Soluble
19 L O 0.0000 Buried
20 S O -0.8010 Soluble
21 V O 0.0000 Buried
22 T O -0.3868 Soluble
23 C O 0.0000 Buried
24 S O -0.9214 Soluble
25 V O -1.0727 Soluble
26 S O -1.3883 Soluble
27 G O -1.9390 Soluble
28 D O -2.5831 Soluble
29 S O -1.5430 Soluble
30 M O -1.2064 Soluble
35 N O -2.1340 Soluble
36 N O -2.0344 Soluble
37 Y O -0.8633 Soluble
38 Y O -0.5983 Soluble
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O -0.7260 Soluble
44 Q O -1.0173 Soluble
45 S O -1.1581 Soluble
46 P O -1.1040 Soluble
47 G O -1.5128 Soluble
48 K O -2.3262 Soluble
49 G O -1.6488 Soluble
50 L O 0.0000 Buried
51 E O -0.9243 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O 0.2579 Aggregation-prone
56 I O 0.0000 Buried
57 S O -2.0530 Soluble
58 D O -3.6086 Soluble
59 R O -3.6260 Soluble
63 E O -3.3535 Soluble
64 S O -1.8734 Soluble
65 A O -0.4097 Soluble
66 T O -0.0418 Soluble
67 Y O -0.0246 Soluble
68 N O -0.5015 Soluble
69 P O -0.6457 Soluble
70 S O -0.6717 Soluble
71 L O -0.7853 Soluble
72 N O -1.5813 Soluble
74 S O -0.9599 Soluble
75 R O -1.2432 Soluble
76 V O -0.3651 Soluble
77 V O 0.4918 Aggregation-prone
78 I O 0.1996 Aggregation-prone
79 S O -0.6867 Soluble
80 R O -1.9729 Soluble
81 D O -2.4393 Soluble
82 T O -1.7948 Soluble
83 S O -1.8192 Soluble
84 K O -2.6466 Soluble
85 N O -2.1881 Soluble
86 Q O -1.6301 Soluble
87 L O 0.0000 Buried
88 S O 0.0000 Buried
89 L O 0.0000 Buried
90 K O -1.0317 Soluble
91 L O -1.0892 Soluble
92 N O -1.9599 Soluble
93 S O -1.2835 Soluble
94 V O 0.0000 Buried
95 T O -0.8739 Soluble
96 P O -0.6782 Soluble
97 A O -0.2877 Soluble
98 D O -0.5704 Soluble
99 T O -0.2021 Soluble
100 A O 0.0000 Buried
101 V O -0.3291 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 R O -1.1504 Soluble
109 R O -1.1779 Soluble
110 G O -1.0216 Soluble
111 Q O -0.5561 Soluble
111A R O 0.1357 Aggregation-prone
111B I O 1.9064 Aggregation-prone
111C Y O 1.8776 Aggregation-prone
111D G O 1.6067 Aggregation-prone
111E V O 2.6531 Aggregation-prone
111F V O 3.0177 Aggregation-prone
112G S O 1.7997 Aggregation-prone
112F F O 2.4504 Aggregation-prone
112E G O 1.6456 Aggregation-prone
112D E O 1.4194 Aggregation-prone
112C F O 1.8157 Aggregation-prone
112B F O 0.8727 Aggregation-prone
112A Y O 0.6940 Aggregation-prone
112 Y O 0.0000 Buried
113 Y O -0.4073 Soluble
114 S O 0.0000 Buried
115 M O 0.0000 Buried
116 D O -0.0638 Soluble
117 V O 0.1404 Aggregation-prone
118 W O 0.0000 Buried
119 G O -1.2205 Soluble
120 K O -2.3555 Soluble
121 G O -1.3704 Soluble
122 T O -0.6421 Soluble
123 T O -0.0051 Soluble
124 V O 0.0000 Buried
125 T O 0.1321 Aggregation-prone
126 V O 0.0000 Buried
127 S O -0.4987 Soluble
128 S O -0.6656 Soluble
129 A O -0.2070 Soluble
11 L R 0.9041 Aggregation-prone
12 S R 0.8683 Aggregation-prone
13 V R 0.4518 Aggregation-prone
14 A R 0.7536 Aggregation-prone
15 L R 0.2970 Aggregation-prone
16 G R -0.9847 Soluble
17 E R -1.6845 Soluble
18 T R -1.3313 Soluble
19 A R 0.0000 Buried
20 R R -1.7876 Soluble
21 I R -0.7976 Soluble
22 S R -1.0803 Soluble
23 C R 0.0000 Buried
24 G R -1.8083 Soluble
25 R R -2.5726 Soluble
26 Q R -2.0491 Soluble
27 A R -0.8231 Soluble
28 L R 0.6503 Aggregation-prone
29 G R 0.2611 Aggregation-prone
36 S R 0.7877 Aggregation-prone
37 R R 0.0000 Buried
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R 0.0000 Buried
44 H R 0.0000 Buried
45 R R -1.6624 Soluble
46 P R -1.3085 Soluble
47 G R -1.5728 Soluble
48 Q R -1.9004 Soluble
49 A R -0.9979 Soluble
50 P R 0.0000 Buried
51 I R 1.1748 Aggregation-prone
52 L R 0.8160 Aggregation-prone
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -0.8308 Soluble
56 N R -1.4839 Soluble
57 N R 0.0000 Buried
65 Q R -2.0743 Soluble
66 D R -1.9542 Soluble
67 R R -1.5446 Soluble
68 P R -0.7736 Soluble
69 S R -0.5878 Soluble
70 G R -0.6603 Soluble
71 I R -0.5121 Soluble
72 P R -1.1435 Soluble
74 E R -2.1709 Soluble
75 R R -1.5170 Soluble
76 F R 0.0000 Buried
77 S R -1.1218 Soluble
78 G R -0.9751 Soluble
79 T R -0.5290 Soluble
80 P R -0.3755 Soluble
81 D R 0.3095 Aggregation-prone
81A I R 1.6836 Aggregation-prone
82 N R 0.3357 Aggregation-prone
83 F R 1.3684 Aggregation-prone
84 G R 0.2274 Aggregation-prone
85 T R -0.2527 Soluble
86 R R -1.1911 Soluble
87 A R 0.0000 Buried
88 T R -0.7621 Soluble
89 L R 0.0000 Buried
90 T R -1.0123 Soluble
91 I R 0.0000 Buried
92 S R -1.5261 Soluble
93 G R -1.3441 Soluble
94 V R 0.0000 Buried
95 E R -2.0699 Soluble
96 A R -1.0970 Soluble
97 G R -1.3357 Soluble
98 D R -1.6214 Soluble
99 E R -2.1677 Soluble
100 A R 0.0000 Buried
101 D R -1.4900 Soluble
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R -0.3357 Soluble
105 H R 0.0000 Buried
106 M R -0.3065 Soluble
107 W R 0.0000 Buried
108 D R 0.0000 Buried
109 S R -0.4869 Soluble
110 R R -1.6417 Soluble
112 S R -0.8660 Soluble
113 G R -0.4431 Soluble
114 F R 0.7061 Aggregation-prone
115 S R 0.2837 Aggregation-prone
116 W R 0.0600 Aggregation-prone
117 S R -0.3819 Soluble
118 F R 0.0000 Buried
119 G R -1.1713 Soluble
120 G R -1.2963 Soluble
121 A R -1.0386 Soluble
122 T R -0.8056 Soluble
123 R R -1.7596 Soluble
124 L R 0.0000 Buried
125 T R 0.1015 Aggregation-prone
126 V R 0.6437 Aggregation-prone
127 L R 1.2605 Aggregation-prone
128 G R 0.4807 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3864 4.6204 CSV PDB
4.5 -0.4268 4.5976 CSV PDB
5.0 -0.4761 4.5668 CSV PDB
5.5 -0.5258 4.5332 CSV PDB
6.0 -0.5675 4.5019 CSV PDB
6.5 -0.5951 4.4782 CSV PDB
7.0 -0.6076 4.4648 CSV PDB
7.5 -0.6094 4.459 CSV PDB
8.0 -0.6052 4.457 CSV PDB
8.5 -0.5966 4.4563 CSV PDB
9.0 -0.5828 4.4561 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH