Zinlirvimab / 8g6u

A4DAB308_8g6u_Q_R | Source PDB: 8g6u | Chains: Q, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5957
Max Score
2.4703
Min Score
-3.3249
Total Score
-140.0
Score CDR
-0.3161
Score non-CDR
-0.696

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) Q (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3249
Maximum Score 2.4703
Average Score -0.5957
Total Score -139.9992

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q Q -1.6024 Soluble
2 V Q -1.0348 Soluble
3 Q Q -1.8239 Soluble
4 L Q -1.4286 Soluble
5 Q Q -2.0603 Soluble
6 E Q -1.3825 Soluble
7 S Q -0.8588 Soluble
8 G Q -0.3042 Soluble
9 P Q 0.0789 Aggregation-prone
11 G Q 0.6026 Aggregation-prone
12 L Q 1.1756 Aggregation-prone
13 V Q -0.1906 Soluble
14 K Q -1.7170 Soluble
15 P Q -1.4499 Soluble
16 S Q -1.6423 Soluble
17 E Q -2.3366 Soluble
18 T Q -1.7891 Soluble
19 L Q 0.0000 Buried
20 S Q -0.7816 Soluble
21 V Q 0.0000 Buried
22 T Q 0.0000 Buried
23 C Q 0.0000 Buried
24 S Q -1.3880 Soluble
25 V Q -1.3627 Soluble
26 S Q -1.4466 Soluble
27 G Q -1.3382 Soluble
28 D Q -1.4031 Soluble
29 S Q -0.7210 Soluble
30 M Q -0.1821 Soluble
35 N Q -1.7134 Soluble
36 N Q -1.6233 Soluble
37 Y Q 0.0000 Buried
38 Y Q -0.9970 Soluble
39 W Q -0.1937 Soluble
40 T Q 0.0000 Buried
41 W Q 0.0000 Buried
42 I Q 0.0000 Buried
43 R Q 0.0000 Buried
44 Q Q -1.1945 Soluble
45 S Q -0.8950 Soluble
46 P Q -1.0548 Soluble
47 G Q -1.5374 Soluble
48 K Q -2.2786 Soluble
49 G Q -1.5250 Soluble
50 L Q -0.9320 Soluble
51 E Q -1.0956 Soluble
52 W Q 0.0000 Buried
53 I Q 0.0000 Buried
54 G Q 0.0000 Buried
55 Y Q -0.0613 Soluble
56 I Q 0.0000 Buried
57 S Q -1.7435 Soluble
58 D Q -2.6141 Soluble
59 R Q -3.2981 Soluble
63 E Q -3.3249 Soluble
64 S Q -1.6400 Soluble
65 A Q -0.2872 Soluble
66 T Q -0.0035 Soluble
67 Y Q 0.0616 Aggregation-prone
68 N Q 0.0000 Buried
69 P Q -0.7214 Soluble
70 S Q -0.7182 Soluble
71 L Q -0.8660 Soluble
72 N Q -1.5902 Soluble
74 S Q -0.8543 Soluble
75 R Q -1.1132 Soluble
76 V Q 0.0000 Buried
77 V Q 0.9265 Aggregation-prone
78 I Q 0.0000 Buried
79 S Q 0.0000 Buried
80 R Q -2.3172 Soluble
81 D Q -3.0345 Soluble
82 T Q -2.0065 Soluble
83 S Q -2.0072 Soluble
84 K Q -2.5858 Soluble
85 N Q -2.3488 Soluble
86 Q Q -2.4907 Soluble
87 L Q 0.0000 Buried
88 S Q -1.0752 Soluble
89 L Q 0.0000 Buried
90 K Q -1.1939 Soluble
91 L Q 0.0000 Buried
92 N Q -1.9448 Soluble
93 S Q -1.5915 Soluble
94 V Q 0.0000 Buried
95 T Q -0.8046 Soluble
96 P Q -0.5182 Soluble
97 A Q -0.2031 Soluble
98 D Q -0.2683 Soluble
99 T Q -0.1822 Soluble
100 A Q -0.1103 Soluble
101 V Q -0.1289 Soluble
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 A Q 0.0000 Buried
106 T Q 0.0000 Buried
107 A Q 0.0000 Buried
108 R Q -1.9894 Soluble
109 R Q -2.3046 Soluble
110 G Q -1.4790 Soluble
111 Q Q -0.8233 Soluble
111A R Q 0.2353 Aggregation-prone
111B I Q 1.7871 Aggregation-prone
111C Y Q 1.7828 Aggregation-prone
111D G Q 1.4269 Aggregation-prone
111E V Q 2.2912 Aggregation-prone
111F V Q 2.4703 Aggregation-prone
112G S Q 1.4499 Aggregation-prone
112F F Q 2.1824 Aggregation-prone
112E G Q 0.9389 Aggregation-prone
112D E Q 0.8687 Aggregation-prone
112C F Q 1.4220 Aggregation-prone
112B F Q 0.4976 Aggregation-prone
112A Y Q 0.2928 Aggregation-prone
112 Y Q 0.0000 Buried
113 Y Q -1.0085 Soluble
114 S Q -0.8477 Soluble
115 M Q 0.0000 Buried
116 D Q -0.4450 Soluble
117 V Q 0.2076 Aggregation-prone
118 W Q 0.0000 Buried
119 G Q 0.0000 Buried
120 K Q -2.5266 Soluble
121 G Q 0.0000 Buried
122 T Q -0.6767 Soluble
123 T Q -0.0683 Soluble
124 V Q 0.0000 Buried
125 T Q 0.2776 Aggregation-prone
126 V Q 0.0304 Aggregation-prone
127 S Q -0.2910 Soluble
11 L R 1.1627 Aggregation-prone
12 S R 0.2362 Aggregation-prone
13 V R 0.2059 Aggregation-prone
14 A R 0.8623 Aggregation-prone
15 L R 1.1855 Aggregation-prone
16 G R -0.7957 Soluble
17 E R -1.5005 Soluble
18 T R -1.0548 Soluble
19 A R -1.1866 Soluble
20 R R -1.6959 Soluble
21 I R -0.6546 Soluble
22 S R -1.0421 Soluble
23 C R -1.1128 Soluble
24 G R -1.7962 Soluble
25 R R -2.5894 Soluble
26 Q R -2.2874 Soluble
27 A R -0.9606 Soluble
28 L R -0.2296 Soluble
29 G R -0.0716 Soluble
36 S R 0.2353 Aggregation-prone
37 R R 0.0000 Buried
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R 0.0000 Buried
44 H R 0.0000 Buried
45 R R -0.8672 Soluble
46 P R -1.0438 Soluble
47 G R -1.5368 Soluble
48 Q R -2.0043 Soluble
49 A R -0.9909 Soluble
50 P R 0.0000 Buried
51 I R 0.7145 Aggregation-prone
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -0.7623 Soluble
56 N R -1.2620 Soluble
57 N R 0.0000 Buried
65 Q R -2.0056 Soluble
66 D R -2.5325 Soluble
67 R R -2.7509 Soluble
68 P R -1.3421 Soluble
69 S R -1.0232 Soluble
70 G R -1.0070 Soluble
71 I R -1.1859 Soluble
72 P R -1.8319 Soluble
74 E R -2.9715 Soluble
75 R R -2.6841 Soluble
76 F R -1.6346 Soluble
77 S R -1.7335 Soluble
78 G R -1.0083 Soluble
79 T R -0.5496 Soluble
80 P R -0.3194 Soluble
81 D R -0.1334 Soluble
81A I R 1.4775 Aggregation-prone
82 N R 0.3142 Aggregation-prone
83 F R 1.2844 Aggregation-prone
84 G R -0.1508 Soluble
85 T R -0.7611 Soluble
86 R R -2.2358 Soluble
87 A R -1.5072 Soluble
88 T R -0.9195 Soluble
89 L R 0.0000 Buried
90 T R -1.2578 Soluble
91 I R 0.0000 Buried
92 S R -1.2758 Soluble
93 G R -1.1277 Soluble
94 V R -0.9485 Soluble
95 E R -1.9984 Soluble
96 A R -1.2621 Soluble
97 G R 0.0000 Buried
98 D R 0.0000 Buried
99 E R -1.7294 Soluble
100 A R 0.0000 Buried
101 D R 0.0000 Buried
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 H R 0.0000 Buried
106 M R 0.0000 Buried
107 W R 0.0000 Buried
108 D R 0.0000 Buried
109 S R -0.5584 Soluble
110 R R -1.8465 Soluble
112 S R -0.9703 Soluble
113 G R -0.5164 Soluble
114 F R 0.4988 Aggregation-prone
115 S R 0.0747 Aggregation-prone
116 W R 0.1638 Aggregation-prone
117 S R -0.2176 Soluble
118 F R 0.0000 Buried
119 G R -0.6798 Soluble
120 G R -1.0771 Soluble
121 A R -0.7130 Soluble
122 T R -0.6452 Soluble
123 R R -1.5487 Soluble
124 L R -0.3847 Soluble
125 T R 0.4980 Aggregation-prone
126 V R 1.2723 Aggregation-prone
127 L R 1.9095 Aggregation-prone
128 G R 0.7812 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4911 4.439 CSV PDB
4.5 -0.53 4.4045 CSV PDB
5.0 -0.5788 4.3565 CSV PDB
5.5 -0.6292 4.3032 CSV PDB
6.0 -0.6719 4.2527 CSV PDB
6.5 -0.7001 4.2135 CSV PDB
7.0 -0.7122 4.1906 CSV PDB
7.5 -0.7114 4.1806 CSV PDB
8.0 -0.7023 4.177 CSV PDB
8.5 -0.6876 4.1758 CSV PDB
9.0 -0.6688 4.1754 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH