Sonavibart / 5jw4

A4DAB244_5jw4_O_P | Source PDB: 5jw4 | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6756
Max Score
2.0877
Min Score
-3.626
Total Score
-289.83
Score CDR
-0.1205
Score non-CDR
-0.7505

Calculation Parameters

Chain Sequence(s) QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPMTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.626
Maximum Score 2.0877
Average Score -0.6756
Total Score -289.8299

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.4264 Soluble
2 V O -0.9987 Soluble
3 Q O -1.4557 Soluble
4 L O 0.0000 Buried
5 Q O -1.7835 Soluble
6 Q O -1.2434 Soluble
7 S O -0.8721 Soluble
8 G O -0.4184 Soluble
9 P O -0.5187 Soluble
11 G O -0.2228 Soluble
12 L O -0.1780 Soluble
13 V O 0.0000 Buried
14 K O -1.8869 Soluble
15 P O -1.4214 Soluble
16 S O -1.4863 Soluble
17 Q O -2.0283 Soluble
18 T O -1.5175 Soluble
19 L O 0.0000 Buried
20 S O -0.7465 Soluble
21 L O 0.0000 Buried
22 T O -0.7697 Soluble
23 C O 0.0000 Buried
24 A O -1.1700 Soluble
25 I O 0.0000 Buried
26 S O -1.0804 Soluble
27 G O -1.1319 Soluble
28 D O -1.1187 Soluble
29 S O -0.4763 Soluble
30 V O 0.0000 Buried
31 S O -0.0479 Soluble
34 S O 0.0330 Aggregation-prone
35 Y O 0.5595 Aggregation-prone
36 N O -1.0665 Soluble
37 A O 0.0000 Buried
38 V O 0.0000 Buried
39 W O 0.0000 Buried
40 N O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O 0.0000 Buried
44 Q O -0.5290 Soluble
45 S O -1.0328 Soluble
46 P O -0.9024 Soluble
47 S O -1.6257 Soluble
48 R O -2.5116 Soluble
49 G O -1.4844 Soluble
50 L O 0.0000 Buried
51 E O 0.0000 Buried
52 W O 0.0000 Buried
53 L O 0.0000 Buried
54 G O 0.0000 Buried
55 R O -0.6776 Soluble
56 T O 0.0000 Buried
57 Y O 0.2245 Aggregation-prone
58 Y O 0.6042 Aggregation-prone
59 R O 0.1248 Aggregation-prone
60 S O 0.0150 Aggregation-prone
62 G O 0.1702 Aggregation-prone
63 W O 0.5271 Aggregation-prone
64 Y O 0.3784 Aggregation-prone
65 N O -0.7424 Soluble
66 D O -1.4327 Soluble
67 Y O -1.5050 Soluble
68 A O 0.0000 Buried
69 E O -2.5697 Soluble
70 S O -1.5787 Soluble
71 V O 0.0000 Buried
72 K O -2.6527 Soluble
74 S O -1.6532 Soluble
75 R O -1.4723 Soluble
76 I O 0.0000 Buried
77 T O -1.2716 Soluble
78 I O 0.0000 Buried
79 N O -1.5240 Soluble
80 P O -1.1696 Soluble
81 D O -1.5992 Soluble
82 T O -1.2754 Soluble
83 S O -1.3691 Soluble
84 K O -2.1998 Soluble
85 N O -1.6065 Soluble
86 Q O -1.5257 Soluble
87 F O 0.0000 Buried
88 S O -0.8786 Soluble
89 L O 0.0000 Buried
90 Q O -1.1502 Soluble
91 L O 0.0000 Buried
92 N O -1.6758 Soluble
93 S O -1.4338 Soluble
94 V O 0.0000 Buried
95 T O -1.3711 Soluble
96 P O -1.3698 Soluble
97 E O -2.2216 Soluble
98 D O 0.0000 Buried
99 T O -0.5673 Soluble
100 A O 0.0000 Buried
101 V O 0.3251 Aggregation-prone
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 R O 0.0000 Buried
107 S O 0.0000 Buried
108 G O 0.0000 Buried
109 H O -0.8187 Soluble
110 I O 0.0107 Aggregation-prone
111 T O 0.3772 Aggregation-prone
111A V O 1.3090 Aggregation-prone
111B F O 2.0877 Aggregation-prone
112C G O 0.6556 Aggregation-prone
112B V O 0.9742 Aggregation-prone
112A N O -0.6600 Soluble
112 V O 0.0000 Buried
113 D O 0.0000 Buried
114 A O 0.0000 Buried
115 F O 0.0000 Buried
116 D O -0.4063 Soluble
117 M O -0.5611 Soluble
118 W O 0.0000 Buried
119 G O 0.0000 Buried
120 Q O -1.9041 Soluble
121 G O 0.0000 Buried
122 T O -0.2054 Soluble
123 M O 0.4135 Aggregation-prone
124 V O 0.0000 Buried
125 T O -0.3441 Soluble
126 V O 0.0000 Buried
127 S O -0.6687 Soluble
128 S O -0.7430 Soluble
129 A O -0.5013 Soluble
130 S O -0.6432 Soluble
131 T O -0.8422 Soluble
132 K O -1.3943 Soluble
133 G O -1.4437 Soluble
134 P O -0.6318 Soluble
135 S O -0.3245 Soluble
136 V O 0.0000 Buried
137 F O 0.0000 Buried
138 P O -1.1956 Soluble
139 L O 0.0000 Buried
140 A O -0.8375 Soluble
141 P O 0.0000 Buried
142 S O -0.5684 Soluble
143 S O -0.4187 Soluble
144 G O -0.6671 Soluble
145 T O -0.5006 Soluble
146 A O 0.0000 Buried
147 A O 0.0000 Buried
148 L O 0.0000 Buried
149 G O 0.0000 Buried
150 C O 0.0000 Buried
151 L O 0.0000 Buried
152 V O 0.0000 Buried
153 K O 0.0000 Buried
154 D O -0.4405 Soluble
155 Y O 0.0000 Buried
156 F O 0.0000 Buried
157 P O 0.0000 Buried
158 E O -0.2100 Soluble
159 P O -0.4564 Soluble
160 V O -0.5440 Soluble
161 T O -0.4671 Soluble
162 V O -0.3038 Soluble
163 S O -0.3245 Soluble
164 W O 0.0000 Buried
165 N O -0.7030 Soluble
166 S O -0.6197 Soluble
167 G O -0.5423 Soluble
168 A O -0.2321 Soluble
169 L O 0.0212 Aggregation-prone
170 T O -0.1689 Soluble
171 S O -0.1835 Soluble
172 G O -0.2146 Soluble
173 V O 0.1565 Aggregation-prone
174 H O -0.2862 Soluble
175 T O 0.0100 Aggregation-prone
176 F O 0.0000 Buried
177 P O -0.1567 Soluble
178 A O 0.3815 Aggregation-prone
179 V O 0.6548 Aggregation-prone
180 L O 1.3559 Aggregation-prone
181 Q O 0.2553 Aggregation-prone
182 S O -0.0640 Soluble
183 S O -0.2207 Soluble
184 G O 0.0358 Aggregation-prone
185 L O 0.1934 Aggregation-prone
186 Y O 0.5452 Aggregation-prone
187 S O 0.0000 Buried
188 L O 0.0000 Buried
189 S O 0.0000 Buried
190 S O 0.0000 Buried
191 V O 0.0000 Buried
192 V O 0.0000 Buried
193 T O -0.1335 Soluble
194 V O 0.0000 Buried
195 P O -0.4922 Soluble
196 S O -0.5502 Soluble
197 S O -0.6107 Soluble
198 S O -0.6254 Soluble
199 L O -0.7942 Soluble
200 G O -0.9294 Soluble
201 T O -0.6817 Soluble
202 Q O -1.1040 Soluble
203 T O -1.0377 Soluble
204 Y O 0.0000 Buried
205 I O -1.2220 Soluble
206 C O 0.0000 Buried
207 N O 0.0000 Buried
208 V O 0.0000 Buried
209 N O -1.7423 Soluble
210 H O 0.0000 Buried
211 K O -2.7284 Soluble
212 P O -1.6361 Soluble
213 S O -1.8868 Soluble
214 N O -2.5709 Soluble
215 T O -2.1002 Soluble
216 K O -2.6078 Soluble
217 V O -1.5911 Soluble
218 D O -2.5276 Soluble
219 K O -2.1252 Soluble
220 K O -2.5897 Soluble
221 V O 0.0000 Buried
222 E O -2.4731 Soluble
223 P O -1.2230 Soluble
4 M P -0.8387 Soluble
5 T P -1.0259 Soluble
6 Q P 0.0000 Buried
7 S P -0.7955 Soluble
8 P P -0.5950 Soluble
9 S P -0.9870 Soluble
10 S P -1.0349 Soluble
11 L P -0.6997 Soluble
12 S P -0.9728 Soluble
13 A P -1.1259 Soluble
14 S P -1.1205 Soluble
15 V P -0.3753 Soluble
16 G P -0.9316 Soluble
17 D P -1.9843 Soluble
18 R P -2.3835 Soluble
19 V P 0.0000 Buried
20 T P -0.6374 Soluble
21 I P 0.0000 Buried
22 T P -0.7909 Soluble
23 C P 0.0000 Buried
24 R P -2.4054 Soluble
25 T P 0.0000 Buried
26 S P -1.2254 Soluble
27 Q P -1.6535 Soluble
28 S P -1.1337 Soluble
29 L P -0.1586 Soluble
36 S P -0.3381 Soluble
37 S P 0.1661 Aggregation-prone
38 Y P 0.1165 Aggregation-prone
39 T P 0.0000 Buried
40 H P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P -1.0898 Soluble
44 Q P -1.5144 Soluble
45 K P -1.8622 Soluble
46 P P -1.4650 Soluble
47 G P -1.6731 Soluble
48 K P -2.6339 Soluble
49 A P -1.6981 Soluble
50 P P 0.0000 Buried
51 K P -1.7312 Soluble
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.0986 Soluble
56 A P -0.0464 Soluble
57 A P 0.0000 Buried
65 S P -0.7023 Soluble
66 S P -0.7938 Soluble
67 R P -1.4972 Soluble
68 G P 0.0000 Buried
69 S P -0.8653 Soluble
70 G P -0.8658 Soluble
71 V P -0.7877 Soluble
72 P P -0.6138 Soluble
74 S P -0.7161 Soluble
75 R P -0.9329 Soluble
76 F P 0.0000 Buried
77 S P -0.7148 Soluble
78 G P -0.5639 Soluble
79 S P -0.6097 Soluble
80 G P -0.9945 Soluble
83 S P -0.9989 Soluble
84 G P -1.2209 Soluble
85 T P -1.5356 Soluble
86 D P -1.7442 Soluble
87 F P 0.0000 Buried
88 T P -0.6705 Soluble
89 L P 0.0000 Buried
90 T P -0.6135 Soluble
91 I P 0.0000 Buried
92 S P -1.3514 Soluble
93 S P -1.2370 Soluble
94 L P 0.0000 Buried
95 Q P -0.9053 Soluble
96 P P -1.5325 Soluble
97 E P -1.7328 Soluble
98 D P 0.0000 Buried
99 F P -1.3885 Soluble
100 A P 0.0000 Buried
101 T P -1.1888 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 Q P 0.0000 Buried
106 Q P 0.0000 Buried
107 S P -0.9099 Soluble
116 R P -1.6173 Soluble
117 T P -0.8885 Soluble
118 F P -0.4973 Soluble
119 G P 0.0000 Buried
120 Q P -1.6918 Soluble
121 G P 0.0000 Buried
122 T P 0.0000 Buried
123 K P -2.0545 Soluble
124 V P 0.0000 Buried
125 E P -1.5448 Soluble
126 I P 0.0000 Buried
127 K P -1.3928 Soluble
128 R P -0.8767 Soluble
129 T P 0.1729 Aggregation-prone
130 V P 1.0392 Aggregation-prone
131 A P 0.4833 Aggregation-prone
132 A P 0.0702 Aggregation-prone
133 P P 0.0000 Buried
134 S P -0.1507 Soluble
135 V P 0.0000 Buried
136 F P 0.0411 Aggregation-prone
137 I P 0.0255 Aggregation-prone
138 F P 0.0000 Buried
139 P P -0.5427 Soluble
140 P P -0.9410 Soluble
141 S P -1.7509 Soluble
142 D P -3.0765 Soluble
143 E P -3.2616 Soluble
144 Q P 0.0000 Buried
145 L P -2.3772 Soluble
146 K P -2.9067 Soluble
147 S P -1.8088 Soluble
148 G P -1.4565 Soluble
149 T P -1.1044 Soluble
150 A P 0.0000 Buried
151 S P 0.0000 Buried
152 V P 0.0000 Buried
153 V P 0.0000 Buried
154 C P 0.0000 Buried
155 L P 0.0000 Buried
156 L P 0.0000 Buried
157 N P 0.0000 Buried
158 N P -0.8365 Soluble
159 F P 0.0000 Buried
160 Y P 0.0000 Buried
161 P P -1.5428 Soluble
162 R P -2.9773 Soluble
163 E P -3.1941 Soluble
164 A P -2.1918 Soluble
165 K P -2.1551 Soluble
166 V P -0.9537 Soluble
167 Q P -0.8159 Soluble
168 W P 0.0000 Buried
169 K P -0.7265 Soluble
170 V P 0.0000 Buried
171 D P -2.0441 Soluble
172 N P -1.6768 Soluble
173 A P -0.4119 Soluble
174 L P 0.4535 Aggregation-prone
175 Q P -0.3031 Soluble
176 S P -0.5180 Soluble
177 G P -0.9867 Soluble
178 N P -0.9203 Soluble
179 S P -1.2309 Soluble
180 Q P -1.4453 Soluble
181 E P -1.3040 Soluble
182 S P -0.5207 Soluble
183 V P -0.5487 Soluble
184 T P -0.9911 Soluble
185 E P -1.9381 Soluble
186 Q P 0.0000 Buried
187 D P -1.8755 Soluble
188 S P -2.0892 Soluble
189 K P -2.4778 Soluble
190 D P -1.7943 Soluble
191 S P 0.0000 Buried
192 T P 0.0000 Buried
193 Y P 0.0000 Buried
194 S P 0.0000 Buried
195 L P 0.0000 Buried
196 S P 0.0000 Buried
197 S P 0.0000 Buried
198 T P -0.6127 Soluble
199 L P 0.0000 Buried
200 T P -0.5195 Soluble
201 L P -0.7215 Soluble
202 S P -1.2870 Soluble
203 K P -2.1367 Soluble
204 A P -1.9930 Soluble
205 D P -2.7395 Soluble
206 Y P 0.0000 Buried
207 E P -3.3727 Soluble
208 K P -3.6260 Soluble
209 H P -3.0993 Soluble
210 K P -3.0556 Soluble
211 V P -1.3763 Soluble
212 Y P 0.0000 Buried
213 A P 0.0000 Buried
214 C P 0.0000 Buried
215 E P -0.9346 Soluble
216 V P 0.0000 Buried
217 T P -1.1169 Soluble
218 H P 0.0000 Buried
219 Q P -1.5960 Soluble
220 G P -0.2124 Soluble
221 L P -0.0895 Soluble
222 S P -0.4133 Soluble
223 S P -0.4202 Soluble
224 P P -0.4729 Soluble
225 V P 0.0172 Aggregation-prone
226 T P -0.5420 Soluble
227 K P -0.7896 Soluble
228 S P -0.5965 Soluble
229 F P -0.9081 Soluble
230 N P -1.8172 Soluble
231 R P -2.5484 Soluble
232 G P -2.1575 Soluble
233 E P -2.4882 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.8028 4.5939 CSV PDB
4.5 -0.8377 4.5939 CSV PDB
5.0 -0.8776 4.5939 CSV PDB
5.5 -0.9134 4.5939 CSV PDB
6.0 -0.9348 4.5939 CSV PDB
6.5 -0.9341 4.5939 CSV PDB
7.0 -0.9122 4.5939 CSV PDB
7.5 -0.8771 4.5939 CSV PDB
8.0 -0.8351 4.5939 CSV PDB
8.5 -0.7885 4.5939 CSV PDB
9.0 -0.7372 4.5939 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH