Nirsevimab / 5udc

A4DAB181_5udc_H_L | Source PDB: 5udc | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6432
Max Score
2.6549
Min Score
-4.0127
Total Score
-275.3
Score CDR
-0.1214
Score non-CDR
-0.717

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVDIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -4.0127
Maximum Score 2.6549
Average Score -0.6432
Total Score -275.3038

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.0996 Aggregation-prone
3 Q H -0.4148 Soluble
4 L H 0.0000 Buried
5 V H 0.5842 Aggregation-prone
6 Q H 0.0000 Buried
7 S H -0.3411 Soluble
8 G H -1.2345 Soluble
9 A H -1.4206 Soluble
11 E H -2.1757 Soluble
12 V H -1.3014 Soluble
13 K H -1.8321 Soluble
14 K H -2.3623 Soluble
15 P H -1.8944 Soluble
16 G H -1.5454 Soluble
17 S H -1.2114 Soluble
18 S H -0.9091 Soluble
19 V H 0.0000 Buried
20 M H 0.3013 Aggregation-prone
21 V H 0.0000 Buried
22 S H 0.0840 Aggregation-prone
23 C H 0.0000 Buried
24 Q H -0.4053 Soluble
25 A H 0.0000 Buried
26 S H -0.1410 Soluble
27 G H -0.2353 Soluble
28 G H -0.1742 Soluble
29 L H -0.3072 Soluble
30 L H 0.0000 Buried
35 E H -1.2072 Soluble
36 D H -0.1070 Soluble
37 Y H 0.0098 Aggregation-prone
38 I H 0.0000 Buried
39 I H 0.0000 Buried
40 N H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.6368 Soluble
45 A H -0.9960 Soluble
46 P H -1.0504 Soluble
47 G H -1.2119 Soluble
48 Q H -1.7390 Soluble
49 G H -1.0713 Soluble
50 P H 0.0000 Buried
51 E H -0.6491 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 G H 0.0000 Buried
56 I H 0.0000 Buried
57 I H 0.0000 Buried
58 P H -0.3397 Soluble
59 V H 0.3310 Aggregation-prone
62 L H 0.1323 Aggregation-prone
63 G H -0.2167 Soluble
64 T H 0.1738 Aggregation-prone
65 V H 0.6239 Aggregation-prone
66 H H 0.0964 Aggregation-prone
67 Y H -0.5176 Soluble
68 G H 0.0000 Buried
69 P H -1.7011 Soluble
70 K H -2.3990 Soluble
71 F H 0.0000 Buried
72 Q H -2.0531 Soluble
74 G H -1.5027 Soluble
75 R H -1.4390 Soluble
76 V H 0.0000 Buried
77 T H -0.5288 Soluble
78 I H 0.0000 Buried
79 T H -0.3448 Soluble
80 A H -1.0206 Soluble
81 D H -1.8759 Soluble
82 E H -2.4699 Soluble
83 S H -1.3368 Soluble
84 T H -1.0867 Soluble
85 D H -1.4987 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.0582 Soluble
89 M H 0.0000 Buried
90 E H -0.6262 Soluble
91 L H 0.0000 Buried
92 S H -0.8673 Soluble
93 S H -1.1621 Soluble
94 L H 0.0000 Buried
95 R H -2.9876 Soluble
96 S H -2.2374 Soluble
97 E H -2.5274 Soluble
98 D H 0.0000 Buried
99 T H -0.9447 Soluble
100 A H 0.0000 Buried
101 M H 0.0352 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 T H 0.0000 Buried
107 E H 0.0000 Buried
108 T H 0.3099 Aggregation-prone
109 A H 0.0000 Buried
110 L H 2.2447 Aggregation-prone
111 V H 2.6549 Aggregation-prone
111A V H 1.4979 Aggregation-prone
111B S H -0.0807 Soluble
111C E H -1.5601 Soluble
112C T H -0.6573 Soluble
112B Y H 0.1486 Aggregation-prone
112A L H 0.1037 Aggregation-prone
112 P H 0.0000 Buried
113 H H -0.0828 Soluble
114 Y H 0.1932 Aggregation-prone
115 F H 0.0000 Buried
116 D H -0.9107 Soluble
117 N H -0.5684 Soluble
118 W H -0.6306 Soluble
119 G H 0.0000 Buried
120 Q H -1.3453 Soluble
121 G H -0.6740 Soluble
122 T H 0.0000 Buried
123 L H -0.3874 Soluble
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.1418 Soluble
128 S H -0.9490 Soluble
129 A H -0.6631 Soluble
130 S H -0.7862 Soluble
131 T H -1.1497 Soluble
132 K H -1.5223 Soluble
133 G H -1.4934 Soluble
134 P H -0.6647 Soluble
135 S H -0.4263 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -0.5033 Soluble
139 L H 0.0000 Buried
140 A H 0.0067 Aggregation-prone
141 P H -0.0497 Soluble
142 S H -0.1957 Soluble
143 G H -0.6092 Soluble
144 T H -0.4889 Soluble
145 A H -0.2120 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.5403 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H 0.0000 Buried
157 E H -0.7615 Soluble
158 P H -0.7528 Soluble
159 V H -0.3391 Soluble
160 T H -0.4488 Soluble
161 V H -0.1997 Soluble
162 S H -0.4156 Soluble
163 W H 0.0000 Buried
164 N H -0.7709 Soluble
165 S H -0.6973 Soluble
166 G H -0.5515 Soluble
167 A H -0.2128 Soluble
168 L H 0.0425 Aggregation-prone
169 T H -0.1091 Soluble
170 S H -0.1443 Soluble
171 G H -0.0952 Soluble
172 V H 0.2389 Aggregation-prone
173 H H -0.2978 Soluble
174 T H -0.1592 Soluble
175 F H 0.0000 Buried
176 P H -0.3549 Soluble
177 A H 0.2652 Aggregation-prone
178 V H 0.6264 Aggregation-prone
179 L H 1.4728 Aggregation-prone
180 Q H 0.3902 Aggregation-prone
181 S H -0.0652 Soluble
182 S H -0.2163 Soluble
183 G H 0.0078 Aggregation-prone
184 L H 0.1430 Aggregation-prone
185 Y H 0.6020 Aggregation-prone
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1074 Soluble
193 V H 0.0000 Buried
194 P H -0.4384 Soluble
195 S H -0.4624 Soluble
196 S H -0.4936 Soluble
197 S H -0.4076 Soluble
198 L H -0.0840 Soluble
199 G H -0.5343 Soluble
200 T H -0.5621 Soluble
201 Q H -0.7929 Soluble
202 T H -0.4130 Soluble
203 Y H -0.0544 Soluble
204 I H -0.7008 Soluble
205 C H 0.0000 Buried
206 N H -1.5622 Soluble
207 V H 0.0000 Buried
208 N H -1.6266 Soluble
209 H H 0.0000 Buried
210 K H -3.0619 Soluble
211 P H -2.1821 Soluble
212 S H -2.1052 Soluble
213 N H -2.5682 Soluble
214 T H -2.0351 Soluble
215 K H -2.6583 Soluble
216 V H -1.7954 Soluble
217 D H -2.6582 Soluble
218 K H -2.1545 Soluble
219 R H -1.8577 Soluble
220 V H 0.1609 Aggregation-prone
1 D L -2.3573 Soluble
2 I L -1.9508 Soluble
3 Q L -1.9322 Soluble
4 M L 0.0000 Buried
5 T L -1.0080 Soluble
6 Q L -0.7361 Soluble
7 S L -0.7127 Soluble
8 P L -0.6466 Soluble
9 S L -0.8937 Soluble
10 S L -1.0662 Soluble
11 L L -0.7216 Soluble
12 S L -0.9044 Soluble
13 A L -1.0481 Soluble
14 A L -1.0346 Soluble
15 V L -0.3260 Soluble
16 G L -1.0007 Soluble
17 D L -1.9636 Soluble
18 R L -2.4338 Soluble
19 V L 0.0000 Buried
20 T L -0.6800 Soluble
21 I L 0.0000 Buried
22 T L -0.7148 Soluble
23 C L 0.0000 Buried
24 Q L -2.1266 Soluble
25 A L -1.9448 Soluble
26 S L -2.0114 Soluble
27 Q L -2.5246 Soluble
28 D L -2.4608 Soluble
29 I L 0.0000 Buried
36 V L 0.2792 Aggregation-prone
37 N L 0.0062 Aggregation-prone
38 Y L 0.4362 Aggregation-prone
39 L L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.7775 Soluble
46 P L -1.4160 Soluble
47 G L -1.7535 Soluble
48 K L -2.4273 Soluble
49 A L -1.5512 Soluble
50 P L 0.0000 Buried
51 K L -1.5593 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.4338 Aggregation-prone
56 V L 0.7912 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.3667 Soluble
66 N L -0.3722 Soluble
67 L L -0.0486 Soluble
68 E L -0.6961 Soluble
69 T L -0.5075 Soluble
70 G L -0.5911 Soluble
71 V L 0.0000 Buried
72 P L -0.4140 Soluble
74 S L -0.4703 Soluble
75 R L -0.7041 Soluble
76 F L 0.0000 Buried
77 S L -0.4239 Soluble
78 G L -0.3178 Soluble
79 S L -0.8311 Soluble
80 G L -1.0346 Soluble
83 S L -0.8415 Soluble
84 G L -1.1273 Soluble
85 T L -1.9310 Soluble
86 D L -2.4758 Soluble
87 F L 0.0000 Buried
88 S L -0.7991 Soluble
89 L L 0.0000 Buried
90 T L -0.6129 Soluble
91 I L 0.0000 Buried
92 S L -1.3211 Soluble
93 S L -1.2329 Soluble
94 L L 0.0000 Buried
95 Q L -0.9740 Soluble
96 P L -1.6301 Soluble
97 E L -2.0270 Soluble
98 D L 0.0000 Buried
99 V L 0.0000 Buried
100 A L 0.0000 Buried
101 T L -1.0817 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 D L -1.2955 Soluble
109 N L -1.6228 Soluble
114 L L -0.8442 Soluble
115 P L 0.0000 Buried
116 L L 0.0000 Buried
117 T L -0.8080 Soluble
118 F L -0.2502 Soluble
119 G L 0.0000 Buried
120 G L -1.1230 Soluble
121 G L -1.0120 Soluble
122 T L 0.0000 Buried
123 K L -2.0960 Soluble
124 V L 0.0000 Buried
125 E L -1.5684 Soluble
126 I L 0.0000 Buried
127 K L -1.3559 Soluble
128 R L -0.9866 Soluble
129 T L 0.1161 Aggregation-prone
130 V L 1.1571 Aggregation-prone
131 A L 0.4847 Aggregation-prone
132 A L 0.1015 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.0226 Soluble
135 V L 0.0000 Buried
136 F L 0.2597 Aggregation-prone
137 I L 0.0858 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.7520 Soluble
140 P L -0.9116 Soluble
141 S L -1.7153 Soluble
142 D L -3.0342 Soluble
143 E L -3.2141 Soluble
144 Q L 0.0000 Buried
145 L L -2.3270 Soluble
146 K L -2.8619 Soluble
147 S L -1.8362 Soluble
148 G L -1.3419 Soluble
149 T L -0.9313 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.5543 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.5634 Soluble
162 R L -2.8242 Soluble
163 E L -3.1610 Soluble
164 A L -2.2350 Soluble
165 K L -2.3982 Soluble
166 V L -1.1450 Soluble
167 Q L -0.6726 Soluble
168 W L 0.0000 Buried
169 K L -0.6626 Soluble
170 V L 0.0000 Buried
171 D L -2.0021 Soluble
172 N L -1.5504 Soluble
173 A L -0.3663 Soluble
174 L L 0.6489 Aggregation-prone
175 Q L -0.2692 Soluble
176 S L -0.4679 Soluble
177 G L -1.0630 Soluble
178 N L -1.0520 Soluble
179 S L -1.2484 Soluble
180 Q L -1.3949 Soluble
181 E L -2.0779 Soluble
182 S L -0.6165 Soluble
183 V L -0.6623 Soluble
184 T L -1.0633 Soluble
185 E L -2.3387 Soluble
186 Q L 0.0000 Buried
187 D L -2.1478 Soluble
188 S L -2.2981 Soluble
189 K L -2.6737 Soluble
190 D L -2.0625 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L -0.7512 Soluble
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6990 Soluble
199 L L 0.0000 Buried
200 T L -0.2918 Soluble
201 L L -0.6282 Soluble
202 S L -1.2835 Soluble
203 K L -2.4098 Soluble
204 A L -2.1942 Soluble
205 D L -3.2105 Soluble
206 Y L 0.0000 Buried
207 E L -4.0127 Soluble
208 K L -3.7583 Soluble
209 H L -3.1281 Soluble
210 K L -3.2622 Soluble
211 V L -1.8465 Soluble
212 Y L 0.0000 Buried
213 A L -0.9747 Soluble
214 C L 0.0000 Buried
215 E L -0.6734 Soluble
216 V L 0.0000 Buried
217 T L -0.8526 Soluble
218 H L 0.0000 Buried
219 Q L -1.5574 Soluble
220 G L -0.2004 Soluble
221 L L -0.1288 Soluble
222 S L -0.4310 Soluble
223 S L -0.3432 Soluble
224 P L -0.2432 Soluble
225 V L 0.1716 Aggregation-prone
226 T L -0.3782 Soluble
227 K L -0.6149 Soluble
228 S L -0.9579 Soluble
229 F L -1.1737 Soluble
230 N L -2.3126 Soluble
231 R L -3.0223 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6396 2.7617 CSV PDB
4.5 -0.69 2.7329 CSV PDB
5.0 -0.7504 2.692 CSV PDB
5.5 -0.8103 2.6436 CSV PDB
6.0 -0.8585 2.5896 CSV PDB
6.5 -0.8856 2.531 CSV PDB
7.0 -0.8896 2.5045 CSV PDB
7.5 -0.877 2.4843 CSV PDB
8.0 -0.855 2.4625 CSV PDB
8.5 -0.8258 2.4402 CSV PDB
9.0 -0.7888 2.4177 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH