Vixticibart / 8tg9

A4DAB296_8tg9_H_L | Source PDB: 8tg9 | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5934
Max Score
2.0587
Min Score
-3.4937
Total Score
-253.38
Score CDR
0.001
Score non-CDR
-0.6722

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGASVTVSCKASGYTFTDYYMHWVRQAPGQGLEWMGWIKPNSGGTNSAQRFQGRITMTWDTSISTAYMELSRLRSDDTAVYYCSRGGPVMNYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPCTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVNIQMTQSPSSLSASVGDRVTITCRASQSIDSYLNWYQQKPGKAPKLLIYVASSLQSGVPSRFSGSGSGKDFTLTISSLQPEDFATYYCQQSYSIPTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4937
Maximum Score 2.0587
Average Score -0.5934
Total Score -253.3815

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.0928 Aggregation-prone
3 Q H -0.2651 Soluble
4 L H 0.0000 Buried
5 V H 0.4984 Aggregation-prone
6 Q H -0.1023 Soluble
7 S H -0.6214 Soluble
8 G H -0.9581 Soluble
9 A H -0.8978 Soluble
11 E H -1.6730 Soluble
12 V H -0.8016 Soluble
13 K H -1.5971 Soluble
14 K H -2.2974 Soluble
15 P H -2.2711 Soluble
16 G H -2.0363 Soluble
17 A H -1.4283 Soluble
18 S H -1.0135 Soluble
19 V H -0.6334 Soluble
20 T H -0.4656 Soluble
21 V H 0.0000 Buried
22 S H -0.0808 Soluble
23 C H 0.0000 Buried
24 K H -0.1916 Soluble
25 A H 0.0000 Buried
26 S H 0.0703 Aggregation-prone
27 G H -0.1878 Soluble
28 Y H 0.0714 Aggregation-prone
29 T H -0.2202 Soluble
30 F H 0.0000 Buried
35 T H -0.9589 Soluble
36 D H -1.0141 Soluble
37 Y H -0.0673 Soluble
38 Y H 0.0000 Buried
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.5111 Soluble
45 A H -0.9675 Soluble
46 P H -0.7974 Soluble
47 G H -1.2275 Soluble
48 Q H -1.7993 Soluble
49 G H -1.2250 Soluble
50 L H 0.0000 Buried
51 E H -0.4113 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 W H -0.0038 Soluble
56 I H 0.0000 Buried
57 K H -0.7590 Soluble
58 P H 0.0000 Buried
59 N H -1.4959 Soluble
62 S H -1.0645 Soluble
63 G H -1.0306 Soluble
64 G H -0.8034 Soluble
65 T H -0.5319 Soluble
66 N H -0.7961 Soluble
67 S H -1.2160 Soluble
68 A H 0.0000 Buried
69 Q H -2.5579 Soluble
70 R H -2.8994 Soluble
71 F H 0.0000 Buried
72 Q H -2.4676 Soluble
74 G H -2.0309 Soluble
75 R H -1.6404 Soluble
76 I H 0.0000 Buried
77 T H -0.5899 Soluble
78 M H 0.0000 Buried
79 T H -0.1430 Soluble
80 W H 0.0339 Aggregation-prone
81 D H -0.1962 Soluble
82 T H -0.0347 Soluble
83 S H 0.4176 Aggregation-prone
84 I H 1.3513 Aggregation-prone
85 S H 0.3391 Aggregation-prone
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H 0.0411 Aggregation-prone
89 M H 0.0000 Buried
90 E H -0.6205 Soluble
91 L H 0.0000 Buried
92 S H -1.4903 Soluble
93 R H -2.4578 Soluble
94 L H 0.0000 Buried
95 R H -2.7188 Soluble
96 S H -1.9786 Soluble
97 D H -2.2982 Soluble
98 D H 0.0000 Buried
99 T H -0.7304 Soluble
100 A H 0.0000 Buried
101 V H 0.1841 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 S H 0.0000 Buried
106 R H -0.0247 Soluble
107 G H 0.0000 Buried
108 G H 0.0000 Buried
109 P H 0.7025 Aggregation-prone
110 V H 0.6907 Aggregation-prone
111 M H 1.0237 Aggregation-prone
111A N H 1.0556 Aggregation-prone
111B Y H 2.0022 Aggregation-prone
112B Y H 1.8372 Aggregation-prone
112A Y H 2.0587 Aggregation-prone
112 Y H 1.7975 Aggregation-prone
113 Y H 1.1997 Aggregation-prone
114 G H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.7194 Soluble
117 V H 0.0113 Aggregation-prone
118 W H -0.3785 Soluble
119 G H 0.0000 Buried
120 Q H -1.4202 Soluble
121 G H -0.7819 Soluble
122 T H 0.0000 Buried
123 T H -0.2999 Soluble
124 V H 0.0000 Buried
125 T H -0.9766 Soluble
126 V H 0.0000 Buried
127 S H -1.2361 Soluble
128 S H -1.0403 Soluble
129 A H -0.7367 Soluble
130 S H -0.9258 Soluble
131 T H -1.0237 Soluble
132 K H -1.7392 Soluble
133 G H -1.6781 Soluble
134 P H -0.8313 Soluble
135 S H -0.4229 Soluble
136 V H 0.0000 Buried
137 F H -0.5448 Soluble
138 P H -0.5749 Soluble
139 L H 0.0000 Buried
140 A H 0.2792 Aggregation-prone
141 P H 0.4196 Aggregation-prone
142 C H 0.5996 Aggregation-prone
143 T H -0.0396 Soluble
144 A H 0.3362 Aggregation-prone
145 A H 0.0000 Buried
146 L H 0.4588 Aggregation-prone
147 G H 0.0000 Buried
148 C H 0.0000 Buried
149 L H 0.0000 Buried
150 V H 0.0000 Buried
151 K H -0.4028 Soluble
152 D H -0.6129 Soluble
153 Y H 0.0000 Buried
154 F H 0.0000 Buried
155 P H -0.9935 Soluble
156 E H -1.4199 Soluble
157 P H -1.1434 Soluble
158 V H -0.1461 Soluble
159 T H 0.2206 Aggregation-prone
160 V H 1.3895 Aggregation-prone
161 S H 0.5806 Aggregation-prone
162 W H 0.0000 Buried
163 N H -0.3988 Soluble
164 S H -0.1167 Soluble
165 G H -0.1921 Soluble
166 A H -0.1730 Soluble
167 L H 0.1585 Aggregation-prone
168 T H 0.0284 Aggregation-prone
169 S H -0.2652 Soluble
170 G H -0.5260 Soluble
171 V H 0.3181 Aggregation-prone
172 H H -0.3371 Soluble
173 T H 0.0617 Aggregation-prone
174 F H 0.0000 Buried
175 P H -0.0450 Soluble
176 A H 0.3627 Aggregation-prone
177 V H 0.8975 Aggregation-prone
178 L H 1.5204 Aggregation-prone
179 Q H 0.3323 Aggregation-prone
180 S H -0.0544 Soluble
181 S H -0.2021 Soluble
182 G H 0.0629 Aggregation-prone
183 L H -0.0040 Soluble
184 Y H 0.3923 Aggregation-prone
185 S H 0.0000 Buried
186 L H 0.3952 Aggregation-prone
187 S H 0.0406 Aggregation-prone
188 S H 0.0000 Buried
189 V H 0.0000 Buried
190 V H 0.4578 Aggregation-prone
191 T H 0.3394 Aggregation-prone
192 V H 0.2430 Aggregation-prone
193 P H -0.1623 Soluble
194 S H -0.1983 Soluble
195 S H -0.2704 Soluble
196 S H -0.3054 Soluble
197 L H 0.1117 Aggregation-prone
198 G H -0.5001 Soluble
199 T H -0.5599 Soluble
200 K H -0.8451 Soluble
201 T H -0.6652 Soluble
202 Y H -0.4462 Soluble
203 T H -1.2748 Soluble
204 C H 0.0000 Buried
205 N H -1.4950 Soluble
206 V H 0.0000 Buried
207 D H -2.1406 Soluble
208 H H 0.0000 Buried
209 K H -2.8341 Soluble
210 P H -1.8544 Soluble
211 S H -2.0183 Soluble
212 N H -2.7179 Soluble
213 T H -2.2571 Soluble
214 K H -2.9385 Soluble
215 V H -1.9855 Soluble
216 D H -2.8431 Soluble
217 K H -2.1809 Soluble
218 R H -2.1237 Soluble
219 V H -0.7659 Soluble
1 N L -1.6459 Soluble
2 I L 0.0000 Buried
3 Q L -1.9877 Soluble
4 M L 0.0000 Buried
5 T L -1.2717 Soluble
6 Q L 0.0000 Buried
7 S L -0.6296 Soluble
8 P L -0.5362 Soluble
9 S L -0.9331 Soluble
10 S L -0.9045 Soluble
11 L L -0.5344 Soluble
12 S L -0.8083 Soluble
13 A L -0.6882 Soluble
14 S L -0.5024 Soluble
15 V L 0.6569 Aggregation-prone
16 G L -0.6562 Soluble
17 D L -1.5442 Soluble
18 R L -2.2743 Soluble
19 V L 0.0000 Buried
20 T L -0.5141 Soluble
21 I L 0.0000 Buried
22 T L -0.7843 Soluble
23 C L 0.0000 Buried
24 R L -2.5475 Soluble
25 A L 0.0000 Buried
26 S L -1.8086 Soluble
27 Q L -2.2073 Soluble
28 S L -1.7089 Soluble
29 I L 0.0000 Buried
36 D L -1.9221 Soluble
37 S L -0.7152 Soluble
38 Y L 0.4602 Aggregation-prone
39 L L 0.0000 Buried
40 N L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -1.3138 Soluble
45 K L -1.5729 Soluble
46 P L -1.4744 Soluble
47 G L -1.6909 Soluble
48 K L -2.5455 Soluble
49 A L -1.5842 Soluble
50 P L 0.0000 Buried
51 K L -1.5133 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.6336 Aggregation-prone
56 V L 0.4820 Aggregation-prone
57 A L 0.0000 Buried
65 S L -0.1281 Soluble
66 S L 0.1934 Aggregation-prone
67 L L 0.4283 Aggregation-prone
68 Q L -0.1541 Soluble
69 S L -0.4788 Soluble
70 G L -0.5012 Soluble
71 V L -0.3042 Soluble
72 P L -0.3254 Soluble
74 S L -0.4454 Soluble
75 R L -0.8634 Soluble
76 F L 0.0000 Buried
77 S L -0.3438 Soluble
78 G L -0.1867 Soluble
79 S L -0.6426 Soluble
80 G L -1.4441 Soluble
83 S L -1.8057 Soluble
84 G L -2.1087 Soluble
85 K L -2.7931 Soluble
86 D L -2.7395 Soluble
87 F L 0.0000 Buried
88 T L -0.7585 Soluble
89 L L 0.0000 Buried
90 T L -0.6320 Soluble
91 I L 0.0000 Buried
92 S L -1.5236 Soluble
93 S L -1.1316 Soluble
94 L L 0.0000 Buried
95 Q L -0.7457 Soluble
96 P L -0.7339 Soluble
97 E L -1.5229 Soluble
98 D L 0.0000 Buried
99 F L -0.4723 Soluble
100 A L 0.0000 Buried
101 T L -0.9800 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 S L 0.0000 Buried
108 Y L 1.3442 Aggregation-prone
114 S L 0.6892 Aggregation-prone
115 I L 0.1891 Aggregation-prone
116 P L 0.3061 Aggregation-prone
117 T L -0.3098 Soluble
118 F L -0.3482 Soluble
119 G L -0.9459 Soluble
120 Q L -1.7691 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 R L -1.9855 Soluble
124 L L 0.0000 Buried
125 E L -1.0097 Soluble
126 I L -0.4937 Soluble
127 K L -1.4928 Soluble
128 R L -1.1748 Soluble
129 T L 0.0721 Aggregation-prone
130 V L 1.1796 Aggregation-prone
131 A L 0.4280 Aggregation-prone
132 A L 0.0357 Aggregation-prone
133 P L -0.0420 Soluble
134 S L -0.1513 Soluble
135 V L 0.1259 Aggregation-prone
136 F L 0.3950 Aggregation-prone
137 I L 0.4379 Aggregation-prone
138 F L 0.0000 Buried
139 P L 0.0000 Buried
140 P L -0.3226 Soluble
141 S L -1.1645 Soluble
142 D L -2.5432 Soluble
143 E L -2.3226 Soluble
144 Q L 0.0000 Buried
145 L L -1.9521 Soluble
146 K L -2.6938 Soluble
147 S L -1.7174 Soluble
148 G L -1.4850 Soluble
149 T L -1.1645 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.1531 Aggregation-prone
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L -0.4927 Soluble
158 N L -1.3027 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.6748 Soluble
162 R L -3.2703 Soluble
163 E L -3.2295 Soluble
164 A L -2.2971 Soluble
165 K L -2.4450 Soluble
166 V L -1.0044 Soluble
167 Q L -1.1990 Soluble
168 W L 0.0000 Buried
169 K L -0.9590 Soluble
170 V L 0.0000 Buried
171 D L -1.3954 Soluble
172 N L -1.2898 Soluble
173 A L -0.4217 Soluble
174 L L 0.4217 Aggregation-prone
175 Q L -0.5780 Soluble
176 S L -0.7836 Soluble
177 G L -1.1009 Soluble
178 N L -1.1237 Soluble
179 S L -1.1702 Soluble
180 Q L -0.9130 Soluble
181 E L -1.0036 Soluble
182 S L -0.3370 Soluble
183 V L -0.5080 Soluble
184 T L -1.1143 Soluble
185 E L -2.3356 Soluble
186 Q L -2.1331 Soluble
187 D L -2.3437 Soluble
188 S L -1.8571 Soluble
189 K L -2.4447 Soluble
190 D L -2.0377 Soluble
191 S L -1.9683 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L -0.0891 Soluble
197 S L 0.0000 Buried
198 T L -0.4118 Soluble
199 L L 0.0000 Buried
200 T L -0.3050 Soluble
201 L L -0.7199 Soluble
202 S L -1.3251 Soluble
203 K L -2.2180 Soluble
204 A L -2.0266 Soluble
205 D L -3.0309 Soluble
206 Y L -2.6723 Soluble
207 E L -3.4937 Soluble
208 K L -3.3762 Soluble
209 H L -2.8205 Soluble
210 K L -2.8355 Soluble
211 V L -1.0054 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.9366 Soluble
216 V L 0.0000 Buried
217 T L -1.1753 Soluble
218 H L 0.0000 Buried
219 Q L -1.7554 Soluble
220 G L -0.3036 Soluble
221 L L -0.1675 Soluble
222 S L -0.4595 Soluble
223 S L -0.3851 Soluble
224 P L -0.4061 Soluble
225 V L 0.1902 Aggregation-prone
226 T L -0.4766 Soluble
227 K L -0.7015 Soluble
228 S L -0.4726 Soluble
229 F L 0.0000 Buried
230 N L -1.2958 Soluble
231 R L -1.8230 Soluble
232 G L -1.9109 Soluble
233 E L -2.0237 Soluble
234 C L -0.5709 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6142 2.7695 CSV PDB
4.5 -0.6573 2.7446 CSV PDB
5.0 -0.7054 2.6979 CSV PDB
5.5 -0.7492 2.633 CSV PDB
6.0 -0.7788 2.5609 CSV PDB
6.5 -0.7876 2.4926 CSV PDB
7.0 -0.7774 2.4396 CSV PDB
7.5 -0.7553 2.4085 CSV PDB
8.0 -0.7268 2.395 CSV PDB
8.5 -0.6927 2.3901 CSV PDB
9.0 -0.652 2.3885 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH