Paridiprubart / 4r7n

A4DAB203_4r7n_Q_R | Source PDB: 4r7n | Chains: Q, R | Done
96
Yes
10 Å
Yes
Avg A4D Score
-0.7012
Max Score
1.7658
Min Score
-3.8742
Total Score
-302.23
Score CDR
-0.314
Score non-CDR
-0.7464

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSDTLSLTCAVSGYPIRFGYSWHWIRQPPGKGLEWMGYIHYSGYTDFNPSLKTRITISRDTSKNQFSLKLSSVTAVDTAVYYCARKDSGNYFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPEIVLTQSPDFQSVTPKEKVTITCRASQSISDHLHWYQQKPDQSPKLLIKYASHAISGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQGYDFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) Q (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.8742
Maximum Score 1.7658
Average Score -0.7012
Total Score -302.2321

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q Q -1.4984 Soluble
2 V Q 0.0000 Buried
3 Q Q -1.9033 Soluble
4 L Q 0.0000 Buried
5 Q Q -1.8959 Soluble
6 E Q 0.0000 Buried
7 S Q -0.7921 Soluble
8 G Q -0.4568 Soluble
9 P Q -0.4778 Soluble
11 G Q -0.4291 Soluble
12 L Q -0.2712 Soluble
13 V Q 0.0000 Buried
14 K Q -2.0996 Soluble
15 P Q -1.1956 Soluble
16 S Q -1.1745 Soluble
17 D Q -1.5151 Soluble
18 T Q -1.1764 Soluble
19 L Q 0.0000 Buried
20 S Q -0.8678 Soluble
21 L Q 0.0000 Buried
22 T Q -0.8190 Soluble
23 C Q 0.0000 Buried
24 A Q -1.2817 Soluble
25 V Q 0.0000 Buried
26 S Q -1.2703 Soluble
27 G Q -0.9132 Soluble
28 Y Q -0.0428 Soluble
29 P Q -0.0998 Soluble
30 I Q 0.0000 Buried
31 R Q -0.5864 Soluble
35 F Q 1.2586 Aggregation-prone
36 G Q 0.5221 Aggregation-prone
37 Y Q 0.4487 Aggregation-prone
38 S Q 0.0000 Buried
39 W Q 0.0000 Buried
40 H Q 0.0000 Buried
41 W Q 0.0000 Buried
42 I Q 0.0000 Buried
43 R Q 0.0000 Buried
44 Q Q 0.0000 Buried
45 P Q -0.5667 Soluble
46 P Q -0.9855 Soluble
47 G Q -1.4648 Soluble
48 K Q -2.2273 Soluble
49 G Q -1.3528 Soluble
50 L Q 0.0000 Buried
51 E Q -0.6591 Soluble
52 W Q 0.0000 Buried
53 M Q 0.0000 Buried
54 G Q 0.0000 Buried
55 Y Q -0.1883 Soluble
56 I Q 0.0000 Buried
57 H Q 0.1096 Aggregation-prone
58 Y Q 0.2842 Aggregation-prone
59 S Q 0.1632 Aggregation-prone
63 G Q 0.0036 Aggregation-prone
64 Y Q 0.7736 Aggregation-prone
65 T Q -0.2430 Soluble
66 D Q -1.4403 Soluble
67 F Q -0.9783 Soluble
68 N Q -0.9495 Soluble
69 P Q -1.0747 Soluble
70 S Q -0.9171 Soluble
71 L Q -0.7872 Soluble
72 K Q -1.7295 Soluble
74 T Q -0.9291 Soluble
75 R Q -1.0331 Soluble
76 I Q 0.0000 Buried
77 T Q -1.0177 Soluble
78 I Q 0.0000 Buried
79 S Q -0.8069 Soluble
80 R Q -1.5524 Soluble
81 D Q -1.9782 Soluble
82 T Q -1.6907 Soluble
83 S Q -1.5120 Soluble
84 K Q -2.3406 Soluble
85 N Q -1.7726 Soluble
86 Q Q -1.7687 Soluble
87 F Q 0.0000 Buried
88 S Q -0.8798 Soluble
89 L Q 0.0000 Buried
90 K Q -1.4805 Soluble
91 L Q 0.0000 Buried
92 S Q -0.8954 Soluble
93 S Q -0.8989 Soluble
94 V Q 0.0000 Buried
95 T Q 0.0386 Aggregation-prone
96 A Q 0.6162 Aggregation-prone
97 V Q 1.7658 Aggregation-prone
98 D Q 0.0000 Buried
99 T Q 0.6554 Aggregation-prone
100 A Q 0.0000 Buried
101 V Q 0.2284 Aggregation-prone
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 A Q 0.0000 Buried
106 R Q 0.0000 Buried
107 K Q -0.3214 Soluble
108 D Q -0.3515 Soluble
109 S Q -0.4650 Soluble
110 G Q -0.4483 Soluble
113 N Q -0.6405 Soluble
114 Y Q 0.0000 Buried
115 F Q 0.0000 Buried
116 P Q -0.1630 Soluble
117 Y Q -0.3750 Soluble
118 W Q -0.6937 Soluble
119 G Q 0.0000 Buried
120 Q Q -2.0549 Soluble
121 G Q -1.1628 Soluble
122 T Q 0.0000 Buried
123 L Q 0.2672 Aggregation-prone
124 V Q 0.0000 Buried
125 T Q 0.0554 Aggregation-prone
126 V Q 0.0000 Buried
127 S Q -0.7240 Soluble
128 S Q -0.8930 Soluble
129 A Q -0.6068 Soluble
130 S Q -0.7225 Soluble
131 T Q -0.8119 Soluble
132 K Q -1.6744 Soluble
133 G Q -1.7996 Soluble
134 P Q 0.0000 Buried
135 S Q -0.3855 Soluble
136 V Q 0.0000 Buried
137 F Q 0.0000 Buried
138 P Q -1.2590 Soluble
139 L Q 0.0000 Buried
140 A Q -0.7539 Soluble
141 P Q 0.0000 Buried
142 S Q -0.7424 Soluble
143 S Q -1.6065 Soluble
144 K Q -2.1305 Soluble
145 S Q -1.5552 Soluble
146 T Q -1.0702 Soluble
147 S Q -1.2022 Soluble
148 G Q -1.1699 Soluble
149 G Q -0.9788 Soluble
150 T Q -0.7075 Soluble
151 A Q 0.0000 Buried
152 A Q 0.0000 Buried
153 L Q 0.0000 Buried
154 G Q 0.0000 Buried
155 C Q 0.0000 Buried
156 L Q 0.0000 Buried
157 V Q 0.0000 Buried
158 K Q 0.0000 Buried
159 D Q -0.6260 Soluble
160 Y Q 0.0000 Buried
161 F Q 0.0000 Buried
162 P Q 0.0000 Buried
163 E Q -0.2688 Soluble
164 P Q -0.6375 Soluble
165 V Q -0.5898 Soluble
166 T Q -0.7675 Soluble
167 V Q -0.5166 Soluble
168 S Q -0.4521 Soluble
169 W Q 0.0000 Buried
170 N Q -0.7030 Soluble
171 S Q -0.5944 Soluble
172 G Q -0.4821 Soluble
173 A Q -0.1985 Soluble
174 L Q -0.0290 Soluble
175 T Q -0.2249 Soluble
176 S Q -0.3172 Soluble
177 G Q -0.4347 Soluble
178 V Q -0.0295 Soluble
179 H Q -0.3632 Soluble
180 T Q -0.0153 Soluble
181 F Q 0.0000 Buried
182 P Q -0.0997 Soluble
183 A Q 0.3419 Aggregation-prone
184 V Q 0.6862 Aggregation-prone
185 L Q 1.1557 Aggregation-prone
186 Q Q 0.2250 Aggregation-prone
187 S Q -0.0850 Soluble
188 S Q -0.2615 Soluble
189 G Q 0.0056 Aggregation-prone
190 L Q -0.0143 Soluble
191 Y Q 0.5188 Aggregation-prone
192 S Q 0.0000 Buried
193 L Q 0.0000 Buried
194 S Q 0.0000 Buried
195 S Q 0.0000 Buried
196 V Q 0.0000 Buried
197 V Q 0.0000 Buried
198 T Q -0.2069 Soluble
199 V Q 0.0000 Buried
200 P Q -0.5525 Soluble
201 S Q 0.0000 Buried
202 S Q -0.8216 Soluble
203 S Q -0.8063 Soluble
204 L Q 0.0000 Buried
205 G Q -1.2009 Soluble
206 T Q -0.8497 Soluble
207 Q Q -1.4407 Soluble
208 T Q -1.3282 Soluble
209 Y Q 0.0000 Buried
210 I Q -1.2364 Soluble
211 C Q 0.0000 Buried
212 N Q -1.5559 Soluble
213 V Q 0.0000 Buried
214 N Q -2.4162 Soluble
215 H Q 0.0000 Buried
216 K Q -2.6666 Soluble
217 P Q -1.6338 Soluble
218 S Q -2.0110 Soluble
219 N Q -2.5008 Soluble
220 T Q -2.2225 Soluble
221 K Q -2.8237 Soluble
222 V Q -1.6216 Soluble
223 D Q -2.3323 Soluble
224 K Q -2.0071 Soluble
225 R Q -2.7286 Soluble
226 V Q 0.0000 Buried
227 E Q -2.5989 Soluble
228 P Q -1.5384 Soluble
1 E R -1.5575 Soluble
2 I R 0.0000 Buried
3 V R 0.8100 Aggregation-prone
4 L R 0.0000 Buried
5 T R -0.7632 Soluble
6 Q R -1.2223 Soluble
7 S R -1.1090 Soluble
8 P R -0.9659 Soluble
9 D R -1.6755 Soluble
10 F R -0.1605 Soluble
11 Q R -0.3863 Soluble
12 S R -0.3771 Soluble
13 V R -1.3732 Soluble
14 T R -1.8904 Soluble
15 P R -2.3325 Soluble
16 K R -3.3859 Soluble
17 E R -3.8742 Soluble
18 K R -3.4187 Soluble
19 V R 0.0000 Buried
20 T R -0.6575 Soluble
21 I R 0.0000 Buried
22 T R -0.7280 Soluble
23 C R 0.0000 Buried
24 R R -1.8743 Soluble
25 A R -0.8726 Soluble
26 S R -0.6711 Soluble
27 Q R -0.9470 Soluble
28 S R -1.2104 Soluble
29 I R 0.0000 Buried
36 S R -1.4679 Soluble
37 D R -2.1951 Soluble
38 H R -1.5702 Soluble
39 L R 0.0000 Buried
40 H R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R 0.0000 Buried
44 Q R 0.0000 Buried
45 K R -1.6275 Soluble
46 P R -1.6730 Soluble
47 D R -2.6206 Soluble
48 Q R -2.3498 Soluble
49 S R -1.4387 Soluble
50 P R 0.0000 Buried
51 K R -1.1390 Soluble
52 L R 0.0000 Buried
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 K R -0.8058 Soluble
56 Y R -0.9160 Soluble
57 A R 0.0000 Buried
65 S R -0.9755 Soluble
66 H R -1.0357 Soluble
67 A R -0.4321 Soluble
68 I R -0.0195 Soluble
69 S R -0.2607 Soluble
70 G R -0.3817 Soluble
71 V R -0.0789 Soluble
72 P R -0.2730 Soluble
74 S R -0.6008 Soluble
75 R R -1.1343 Soluble
76 F R 0.0000 Buried
77 S R -0.7641 Soluble
78 G R -0.6832 Soluble
79 S R -0.8681 Soluble
80 G R -1.1992 Soluble
83 S R -1.3779 Soluble
84 G R -1.3364 Soluble
85 T R -1.5829 Soluble
86 D R -1.6440 Soluble
87 F R 0.0000 Buried
88 T R -0.6524 Soluble
89 L R 0.0000 Buried
90 T R -0.8896 Soluble
91 I R 0.0000 Buried
92 N R -2.8786 Soluble
93 S R -2.9550 Soluble
94 L R 0.0000 Buried
95 E R -2.2906 Soluble
96 A R -2.4346 Soluble
97 E R -2.6210 Soluble
98 D R 0.0000 Buried
99 A R 0.0000 Buried
100 A R 0.0000 Buried
101 T R -0.4777 Soluble
102 Y R 0.0000 Buried
103 Y R 0.0000 Buried
104 C R 0.0000 Buried
105 Q R 0.0000 Buried
106 Q R 0.0000 Buried
107 G R 0.0000 Buried
108 Y R -0.7632 Soluble
109 D R -1.4973 Soluble
114 F R -0.6217 Soluble
115 P R -0.7335 Soluble
116 L R 0.0000 Buried
117 T R -0.1462 Soluble
118 F R 0.0000 Buried
119 G R 0.0000 Buried
120 G R -1.1502 Soluble
121 G R -1.1292 Soluble
122 T R 0.0000 Buried
123 K R -0.8250 Soluble
124 V R 0.0000 Buried
125 E R -0.6290 Soluble
126 I R 0.0000 Buried
127 K R -1.3218 Soluble
128 R R -1.0012 Soluble
129 T R -0.0583 Soluble
130 V R 0.5586 Aggregation-prone
131 A R 0.1332 Aggregation-prone
132 A R -0.1616 Soluble
133 P R 0.0000 Buried
134 S R -0.1654 Soluble
135 V R 0.0000 Buried
136 F R 0.1870 Aggregation-prone
137 I R 0.2225 Aggregation-prone
138 F R 0.0000 Buried
139 P R -0.7947 Soluble
140 P R 0.0000 Buried
141 S R -1.7270 Soluble
142 D R -3.0674 Soluble
143 E R -3.2213 Soluble
144 Q R 0.0000 Buried
145 L R -2.1980 Soluble
146 K R -2.8539 Soluble
147 S R -1.8174 Soluble
148 G R -1.4512 Soluble
149 T R -1.0811 Soluble
150 A R 0.0000 Buried
151 S R 0.0000 Buried
152 V R 0.0000 Buried
153 V R 0.0000 Buried
154 C R 0.0000 Buried
155 L R 0.0000 Buried
156 L R 0.0000 Buried
157 N R -0.4522 Soluble
158 N R -0.9957 Soluble
159 F R 0.0000 Buried
160 Y R 0.0000 Buried
161 P R -1.1989 Soluble
162 R R -1.8012 Soluble
163 E R -2.5546 Soluble
164 A R -2.0330 Soluble
165 K R -2.2957 Soluble
166 V R -0.9802 Soluble
167 Q R -0.5873 Soluble
168 W R 0.0000 Buried
169 K R -0.5400 Soluble
170 V R 0.0000 Buried
171 D R -1.9330 Soluble
172 N R -1.4028 Soluble
173 A R -0.2722 Soluble
174 L R 0.7940 Aggregation-prone
175 Q R -0.0433 Soluble
176 S R -0.4373 Soluble
177 G R -0.8585 Soluble
178 N R -0.7184 Soluble
179 S R -0.9137 Soluble
180 Q R -1.0675 Soluble
181 E R -1.1025 Soluble
182 S R -0.3027 Soluble
183 V R -0.0858 Soluble
184 T R -0.3811 Soluble
185 E R -1.3047 Soluble
186 Q R 0.0000 Buried
187 D R -2.0223 Soluble
188 S R -2.3317 Soluble
189 K R -2.9299 Soluble
190 D R -2.4221 Soluble
191 S R 0.0000 Buried
192 T R 0.0000 Buried
193 Y R 0.0000 Buried
194 S R 0.0000 Buried
195 L R 0.0000 Buried
196 S R 0.0000 Buried
197 S R 0.0000 Buried
198 T R -0.4885 Soluble
199 L R 0.0000 Buried
200 T R -0.4192 Soluble
201 L R -0.6828 Soluble
202 S R -1.1532 Soluble
203 K R -2.1296 Soluble
204 A R -1.9275 Soluble
205 D R -2.9740 Soluble
206 Y R 0.0000 Buried
207 E R -3.3970 Soluble
208 K R -3.5533 Soluble
209 H R -3.1824 Soluble
210 K R -3.1016 Soluble
211 V R -1.7264 Soluble
212 Y R 0.0000 Buried
213 A R 0.0000 Buried
214 C R 0.0000 Buried
215 E R -0.8601 Soluble
216 V R 0.0000 Buried
217 T R -1.1550 Soluble
218 H R 0.0000 Buried
219 Q R -1.6178 Soluble
220 G R -0.4360 Soluble
221 L R -0.2562 Soluble
222 S R -0.4612 Soluble
223 S R -0.4095 Soluble
224 P R -0.5157 Soluble
225 V R 0.0812 Aggregation-prone
226 T R -0.3874 Soluble
227 K R -0.5656 Soluble
228 S R -0.5339 Soluble
229 F R -1.0992 Soluble
230 N R -2.3286 Soluble
231 R R -2.5400 Soluble
232 G R -2.1326 Soluble
233 E R -2.4514 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7313 2.7673 CSV PDB
4.5 -0.7794 2.7685 CSV PDB
5.0 -0.8333 2.7714 CSV PDB
5.5 -0.8821 2.7765 CSV PDB
6.0 -0.9134 2.7821 CSV PDB
6.5 -0.9194 2.7862 CSV PDB
7.0 -0.903 2.7881 CSV PDB
7.5 -0.8735 2.7888 CSV PDB
8.0 -0.8368 2.7889 CSV PDB
8.5 -0.7932 2.7887 CSV PDB
9.0 -0.7416 2.7877 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH