Sonavibart / 5jw4

A4DAB244_5jw4_U_V | Source PDB: 5jw4 | Chains: U, V | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6581
Max Score
2.2805
Min Score
-3.6097
Total Score
-282.33
Score CDR
-0.0276
Score non-CDR
-0.7432

Calculation Parameters

Chain Sequence(s) QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPMTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) U (Heavy), V (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6097
Maximum Score 2.2805
Average Score -0.6581
Total Score -282.3277

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q U -1.4265 Soluble
2 V U -1.1471 Soluble
3 Q U -1.4564 Soluble
4 L U 0.0000 Buried
5 Q U -1.7620 Soluble
6 Q U -1.2482 Soluble
7 S U -0.8843 Soluble
8 G U -0.4672 Soluble
9 P U -0.5622 Soluble
11 G U -0.3214 Soluble
12 L U -0.3357 Soluble
13 V U 0.0000 Buried
14 K U -2.2385 Soluble
15 P U -1.5727 Soluble
16 S U -1.5240 Soluble
17 Q U -2.0568 Soluble
18 T U -1.4597 Soluble
19 L U 0.0000 Buried
20 S U -0.7154 Soluble
21 L U 0.0000 Buried
22 T U -0.7811 Soluble
23 C U 0.0000 Buried
24 A U -1.1766 Soluble
25 I U 0.0000 Buried
26 S U -1.1010 Soluble
27 G U -1.1606 Soluble
28 D U -1.1858 Soluble
29 S U -0.5466 Soluble
30 V U 0.0000 Buried
31 S U -0.0529 Soluble
34 S U 0.0139 Aggregation-prone
35 Y U 0.5520 Aggregation-prone
36 N U -0.8511 Soluble
37 A U 0.0000 Buried
38 V U 0.0000 Buried
39 W U 0.0000 Buried
40 N U 0.0000 Buried
41 W U 0.0000 Buried
42 I U 0.0000 Buried
43 R U 0.0000 Buried
44 Q U -0.5323 Soluble
45 S U -1.0448 Soluble
46 P U -0.8987 Soluble
47 S U -1.6302 Soluble
48 R U -2.5155 Soluble
49 G U -1.4944 Soluble
50 L U 0.0000 Buried
51 E U 0.0000 Buried
52 W U 0.0000 Buried
53 L U 0.0000 Buried
54 G U 0.0000 Buried
55 R U -0.6311 Soluble
56 T U 0.0000 Buried
57 Y U 0.2599 Aggregation-prone
58 Y U 0.6238 Aggregation-prone
59 R U 0.1266 Aggregation-prone
60 S U 0.0173 Aggregation-prone
62 G U 0.1749 Aggregation-prone
63 W U 0.5406 Aggregation-prone
64 Y U 0.4225 Aggregation-prone
65 N U -0.6262 Soluble
66 D U -1.2542 Soluble
67 Y U -1.4159 Soluble
68 A U 0.0000 Buried
69 E U -2.5471 Soluble
70 S U -1.5710 Soluble
71 V U 0.0000 Buried
72 K U -2.6239 Soluble
74 S U -1.6124 Soluble
75 R U -1.3527 Soluble
76 I U 0.0000 Buried
77 T U -1.1849 Soluble
78 I U 0.0000 Buried
79 N U -1.5083 Soluble
80 P U -1.1658 Soluble
81 D U -1.5922 Soluble
82 T U -1.2693 Soluble
83 S U -1.3647 Soluble
84 K U -2.1981 Soluble
85 N U -1.6168 Soluble
86 Q U -1.5310 Soluble
87 F U 0.0000 Buried
88 S U -0.8895 Soluble
89 L U 0.0000 Buried
90 Q U -1.0106 Soluble
91 L U 0.0000 Buried
92 N U -1.4018 Soluble
93 S U -1.3492 Soluble
94 V U 0.0000 Buried
95 T U -1.4198 Soluble
96 P U -1.4275 Soluble
97 E U -2.2279 Soluble
98 D U 0.0000 Buried
99 T U -0.5893 Soluble
100 A U 0.0000 Buried
101 V U 0.3003 Aggregation-prone
102 Y U 0.0000 Buried
103 Y U 0.0000 Buried
104 C U 0.0000 Buried
105 A U 0.0000 Buried
106 R U 0.0000 Buried
107 S U 0.0000 Buried
108 G U 0.0000 Buried
109 H U -0.8047 Soluble
110 I U 0.0593 Aggregation-prone
111 T U 0.7409 Aggregation-prone
111A V U 1.5538 Aggregation-prone
111B F U 2.2805 Aggregation-prone
112C G U 0.9707 Aggregation-prone
112B V U 1.5393 Aggregation-prone
112A N U 0.3291 Aggregation-prone
112 V U 0.0000 Buried
113 D U 0.0000 Buried
114 A U 0.0000 Buried
115 F U 0.0000 Buried
116 D U -0.6299 Soluble
117 M U -0.6181 Soluble
118 W U 0.0000 Buried
119 G U 0.0000 Buried
120 Q U -1.9146 Soluble
121 G U 0.0000 Buried
122 T U -0.3314 Soluble
123 M U 0.1291 Aggregation-prone
124 V U 0.0000 Buried
125 T U -0.4476 Soluble
126 V U 0.0000 Buried
127 S U -0.7975 Soluble
128 S U -0.8762 Soluble
129 A U -0.5498 Soluble
130 S U -0.6657 Soluble
131 T U -0.7966 Soluble
132 K U -1.2715 Soluble
133 G U -1.3927 Soluble
134 P U -0.6048 Soluble
135 S U -0.3145 Soluble
136 V U 0.0000 Buried
137 F U 0.0000 Buried
138 P U -1.1944 Soluble
139 L U 0.0000 Buried
140 A U -0.8350 Soluble
141 P U 0.0000 Buried
142 S U -0.5611 Soluble
143 S U -0.4168 Soluble
144 G U -0.6651 Soluble
145 T U -0.4962 Soluble
146 A U 0.0000 Buried
147 A U 0.0000 Buried
148 L U 0.0000 Buried
149 G U 0.0000 Buried
150 C U 0.0000 Buried
151 L U 0.0000 Buried
152 V U 0.0000 Buried
153 K U 0.0000 Buried
154 D U -0.4149 Soluble
155 Y U 0.0000 Buried
156 F U 0.0000 Buried
157 P U 0.0000 Buried
158 E U -0.3814 Soluble
159 P U -0.6308 Soluble
160 V U -0.6210 Soluble
161 T U -0.5398 Soluble
162 V U -0.3689 Soluble
163 S U -0.4002 Soluble
164 W U 0.0000 Buried
165 N U -0.7554 Soluble
166 S U -0.6666 Soluble
167 G U -0.5677 Soluble
168 A U -0.2369 Soluble
169 L U 0.0130 Aggregation-prone
170 T U -0.1720 Soluble
171 S U -0.1863 Soluble
172 G U -0.2355 Soluble
173 V U 0.1530 Aggregation-prone
174 H U -0.2996 Soluble
175 T U 0.0048 Aggregation-prone
176 F U 0.0000 Buried
177 P U -0.2465 Soluble
178 A U 0.2483 Aggregation-prone
179 V U 0.5941 Aggregation-prone
180 L U 1.2272 Aggregation-prone
181 Q U 0.3292 Aggregation-prone
182 S U -0.0955 Soluble
183 S U -0.2061 Soluble
184 G U 0.0467 Aggregation-prone
185 L U 0.1861 Aggregation-prone
186 Y U 0.4613 Aggregation-prone
187 S U 0.0000 Buried
188 L U 0.0000 Buried
189 S U 0.0000 Buried
190 S U 0.0000 Buried
191 V U 0.0000 Buried
192 V U 0.0000 Buried
193 T U -0.1347 Soluble
194 V U 0.0000 Buried
195 P U -0.4855 Soluble
196 S U -0.5375 Soluble
197 S U -0.6034 Soluble
198 S U -0.6159 Soluble
199 L U -0.7721 Soluble
200 G U -0.9168 Soluble
201 T U -0.6776 Soluble
202 Q U -1.1040 Soluble
203 T U -1.0414 Soluble
204 Y U 0.0000 Buried
205 I U -1.2929 Soluble
206 C U 0.0000 Buried
207 N U -1.5186 Soluble
208 V U 0.0000 Buried
209 N U -1.8719 Soluble
210 H U 0.0000 Buried
211 K U -2.7754 Soluble
212 P U -1.6484 Soluble
213 S U -1.8803 Soluble
214 N U -2.5770 Soluble
215 T U -2.1148 Soluble
216 K U -2.6652 Soluble
217 V U -1.6446 Soluble
218 D U -2.5976 Soluble
219 K U -2.1560 Soluble
220 K U -2.6184 Soluble
221 V U 0.0000 Buried
222 E U -2.4700 Soluble
223 P U -1.2166 Soluble
4 M V -0.8374 Soluble
5 T V -1.0264 Soluble
6 Q V 0.0000 Buried
7 S V -0.7878 Soluble
8 P V -0.4533 Soluble
9 S V -0.7609 Soluble
10 S V -0.6480 Soluble
11 L V -0.4405 Soluble
12 S V -0.8015 Soluble
13 A V -1.0397 Soluble
14 S V -0.9887 Soluble
15 V V -0.3094 Soluble
16 G V -0.9731 Soluble
17 D V -1.9784 Soluble
18 R V -2.3889 Soluble
19 V V 0.0000 Buried
20 T V -0.6314 Soluble
21 I V 0.0000 Buried
22 T V -0.7847 Soluble
23 C V 0.0000 Buried
24 R V -2.4020 Soluble
25 T V 0.0000 Buried
26 S V -1.2133 Soluble
27 Q V -1.6303 Soluble
28 S V -1.0865 Soluble
29 L V -0.0298 Soluble
36 S V -0.2614 Soluble
37 S V 0.4077 Aggregation-prone
38 Y V 0.3716 Aggregation-prone
39 T V 0.0000 Buried
40 H V 0.0000 Buried
41 W V 0.0000 Buried
42 Y V 0.0000 Buried
43 Q V 0.0000 Buried
44 Q V -1.2949 Soluble
45 K V -1.7804 Soluble
46 P V -1.4467 Soluble
47 G V -1.6520 Soluble
48 K V -2.5712 Soluble
49 A V -1.6212 Soluble
50 P V 0.0000 Buried
51 K V -1.5932 Soluble
52 L V 0.0000 Buried
53 L V 0.0000 Buried
54 I V 0.0000 Buried
55 Y V -0.0835 Soluble
56 A V 0.0451 Aggregation-prone
57 A V 0.0000 Buried
65 S V -0.6937 Soluble
66 S V -0.8058 Soluble
67 R V -1.6090 Soluble
68 G V 0.0000 Buried
69 S V -0.9551 Soluble
70 G V -0.9545 Soluble
71 V V 0.0000 Buried
72 P V -0.7152 Soluble
74 S V -0.7711 Soluble
75 R V -0.9629 Soluble
76 F V 0.0000 Buried
77 S V -0.7513 Soluble
78 G V -0.5642 Soluble
79 S V -0.6044 Soluble
80 G V -0.9743 Soluble
83 S V -0.9803 Soluble
84 G V -1.2021 Soluble
85 T V -1.5139 Soluble
86 D V -1.7244 Soluble
87 F V 0.0000 Buried
88 T V -0.6646 Soluble
89 L V 0.0000 Buried
90 T V -0.6088 Soluble
91 I V 0.0000 Buried
92 S V -1.3494 Soluble
93 S V -1.2464 Soluble
94 L V 0.0000 Buried
95 Q V -0.9496 Soluble
96 P V -1.5913 Soluble
97 E V -1.8424 Soluble
98 D V 0.0000 Buried
99 F V 0.0000 Buried
100 A V 0.0000 Buried
101 T V -0.7721 Soluble
102 Y V 0.0000 Buried
103 Y V 0.0000 Buried
104 C V 0.0000 Buried
105 Q V 0.0000 Buried
106 Q V 0.0000 Buried
107 S V -0.5036 Soluble
116 R V -1.1238 Soluble
117 T V -0.6309 Soluble
118 F V -0.3796 Soluble
119 G V 0.0000 Buried
120 Q V -1.5977 Soluble
121 G V 0.0000 Buried
122 T V 0.0000 Buried
123 K V -1.1313 Soluble
124 V V 0.0000 Buried
125 E V -1.2314 Soluble
126 I V 0.0000 Buried
127 K V -1.1529 Soluble
128 R V -0.8218 Soluble
129 T V 0.0353 Aggregation-prone
130 V V 0.6395 Aggregation-prone
131 A V 0.2580 Aggregation-prone
132 A V -0.0550 Soluble
133 P V 0.0000 Buried
134 S V -0.1702 Soluble
135 V V 0.0000 Buried
136 F V 0.1144 Aggregation-prone
137 I V 0.0896 Aggregation-prone
138 F V 0.0000 Buried
139 P V -0.5262 Soluble
140 P V -0.9052 Soluble
141 S V -1.7231 Soluble
142 D V -3.0908 Soluble
143 E V -3.2271 Soluble
144 Q V 0.0000 Buried
145 L V -2.2968 Soluble
146 K V -2.8673 Soluble
147 S V -1.7919 Soluble
148 G V -1.2912 Soluble
149 T V -1.0547 Soluble
150 A V 0.0000 Buried
151 S V 0.0000 Buried
152 V V 0.0000 Buried
153 V V 0.0000 Buried
154 C V 0.0000 Buried
155 L V 0.0000 Buried
156 L V 0.0000 Buried
157 N V 0.0000 Buried
158 N V -0.9961 Soluble
159 F V 0.0000 Buried
160 Y V 0.0000 Buried
161 P V -1.6201 Soluble
162 R V -3.0808 Soluble
163 E V -3.2845 Soluble
164 A V -2.4375 Soluble
165 K V -2.5935 Soluble
166 V V 0.0000 Buried
167 Q V -0.7984 Soluble
168 W V 0.0000 Buried
169 K V -0.6119 Soluble
170 V V 0.0000 Buried
171 D V -2.0040 Soluble
172 N V -1.6354 Soluble
173 A V -0.3333 Soluble
174 L V 0.6372 Aggregation-prone
175 Q V -0.1825 Soluble
176 S V -0.4461 Soluble
177 G V -0.8825 Soluble
178 N V -0.8035 Soluble
179 S V -1.0125 Soluble
180 Q V -1.0594 Soluble
181 E V -1.5343 Soluble
182 S V -0.6515 Soluble
183 V V -0.6685 Soluble
184 T V -0.9989 Soluble
185 E V -1.8977 Soluble
186 Q V 0.0000 Buried
187 D V -2.0080 Soluble
188 S V -2.1993 Soluble
189 K V -2.6044 Soluble
190 D V -2.0089 Soluble
191 S V 0.0000 Buried
192 T V 0.0000 Buried
193 Y V 0.0000 Buried
194 S V 0.0000 Buried
195 L V 0.0000 Buried
196 S V 0.0000 Buried
197 S V 0.0000 Buried
198 T V -0.5001 Soluble
199 L V 0.0000 Buried
200 T V -0.4202 Soluble
201 L V -0.6911 Soluble
202 S V -1.2313 Soluble
203 K V -2.0418 Soluble
204 A V -1.9331 Soluble
205 D V -2.6527 Soluble
206 Y V 0.0000 Buried
207 E V -3.3637 Soluble
208 K V -3.6097 Soluble
209 H V -3.0736 Soluble
210 K V -3.0210 Soluble
211 V V -1.3588 Soluble
212 Y V 0.0000 Buried
213 A V 0.0000 Buried
214 C V 0.0000 Buried
215 E V -0.9445 Soluble
216 V V 0.0000 Buried
217 T V -1.3286 Soluble
218 H V 0.0000 Buried
219 Q V -1.7214 Soluble
220 G V -0.3455 Soluble
221 L V -0.1813 Soluble
222 S V -0.4469 Soluble
223 S V -0.4784 Soluble
224 P V -0.6211 Soluble
225 V V -0.1147 Soluble
226 T V -0.5593 Soluble
227 K V -0.7304 Soluble
228 S V -0.5599 Soluble
229 F V -0.8937 Soluble
230 N V -1.7921 Soluble
231 R V -2.5002 Soluble
232 G V -2.3151 Soluble
233 E V -2.4680 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7674 4.7336 CSV PDB
4.5 -0.8028 4.7336 CSV PDB
5.0 -0.8435 4.7336 CSV PDB
5.5 -0.8805 4.7336 CSV PDB
6.0 -0.9043 4.7336 CSV PDB
6.5 -0.9076 4.7336 CSV PDB
7.0 -0.8904 4.7336 CSV PDB
7.5 -0.8596 4.7336 CSV PDB
8.0 -0.8213 4.7336 CSV PDB
8.5 -0.7777 4.7336 CSV PDB
9.0 -0.729 4.7336 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH