Cosfroviximab / 5ken

A4DAB073_5ken_J_I | Source PDB: 5ken | Chains: J, I | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6311
Max Score
1.4211
Min Score
-3.1291
Total Score
-143.88
Score CDR
-0.4704
Score non-CDR
-0.675

Calculation Parameters

Chain Sequence(s) DVKLLESGGGLVQPGGSLKLSCAASGFSLSTSGVGVGWFRQPSGKGLEWLALIWWDDDKYYNPSLKSQLSISKDFSRNQVFLKISNVDIADTATYYCARRDPFGYDNAMGYWGQGTSVTVSDIVMTQSPLSLSTSVGDRVSLTCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSSYPLTFGAGTKLELR input.pdb
Selected Chain(s) J (Heavy), I (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1291
Maximum Score 1.4211
Average Score -0.6311
Total Score -143.8828

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 D J -2.1648 Soluble
2 V J -1.6072 Soluble
3 K J -2.3001 Soluble
4 L J 0.0000 Buried
5 L J -0.7181 Soluble
6 E J -0.8413 Soluble
7 S J -0.8655 Soluble
8 G J -1.1696 Soluble
9 G J -0.9412 Soluble
11 G J -0.0971 Soluble
12 L J 0.9872 Aggregation-prone
13 V J 0.1830 Aggregation-prone
14 Q J -1.0425 Soluble
15 P J -0.7876 Soluble
16 G J -1.3764 Soluble
17 G J -1.4141 Soluble
18 S J -1.6140 Soluble
19 L J 0.0000 Buried
20 K J -2.0304 Soluble
21 L J 0.0000 Buried
22 S J -0.7667 Soluble
23 C J 0.0000 Buried
24 A J -0.8771 Soluble
25 A J 0.0000 Buried
26 S J -1.3459 Soluble
27 G J -1.3835 Soluble
28 F J -0.5814 Soluble
29 S J -0.4667 Soluble
30 L J 0.0000 Buried
31 S J -0.3734 Soluble
34 T J -0.3696 Soluble
35 S J -0.8507 Soluble
36 G J -0.8771 Soluble
37 V J 0.0000 Buried
38 G J 0.0000 Buried
39 V J 0.0000 Buried
40 G J 0.0000 Buried
41 W J 0.0000 Buried
42 F J 0.0000 Buried
43 R J 0.0000 Buried
44 Q J 0.0000 Buried
45 P J -0.9566 Soluble
46 S J -1.0129 Soluble
47 G J -1.5521 Soluble
48 K J -2.1218 Soluble
49 G J -1.2212 Soluble
50 L J 0.0000 Buried
51 E J -0.7823 Soluble
52 W J 0.0000 Buried
53 L J 0.0000 Buried
54 A J 0.0000 Buried
55 L J 0.0000 Buried
56 I J 0.0000 Buried
57 W J -1.4580 Soluble
58 W J -1.3356 Soluble
59 D J -2.6564 Soluble
63 D J -3.1291 Soluble
64 D J -2.4724 Soluble
65 K J -1.8450 Soluble
66 Y J -0.3995 Soluble
67 Y J -0.3459 Soluble
68 N J 0.0000 Buried
69 P J -1.0850 Soluble
70 S J -0.9642 Soluble
71 L J -0.8941 Soluble
72 K J -1.8300 Soluble
74 S J -1.2642 Soluble
75 Q J -1.7210 Soluble
76 L J 0.0000 Buried
77 S J -1.2966 Soluble
78 I J 0.0000 Buried
79 S J -1.0293 Soluble
80 K J -1.4084 Soluble
81 D J -1.3994 Soluble
82 F J -0.9798 Soluble
83 S J -1.3264 Soluble
84 R J -2.3104 Soluble
85 N J -1.5315 Soluble
86 Q J -1.2972 Soluble
87 V J 0.0000 Buried
88 F J -0.8113 Soluble
89 L J 0.0000 Buried
90 K J -2.1190 Soluble
91 I J 0.0000 Buried
92 S J -1.8302 Soluble
93 N J -2.0532 Soluble
94 V J 0.0000 Buried
95 D J -0.5158 Soluble
96 I J 1.4211 Aggregation-prone
97 A J 0.7920 Aggregation-prone
98 D J 0.0000 Buried
99 T J 0.5621 Aggregation-prone
100 A J 0.0000 Buried
101 T J -0.5185 Soluble
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 A J 0.0000 Buried
106 R J 0.0000 Buried
107 R J 0.0000 Buried
108 D J -0.1482 Soluble
109 P J 0.2343 Aggregation-prone
110 F J 0.4461 Aggregation-prone
111 G J 0.2146 Aggregation-prone
112A Y J 0.9671 Aggregation-prone
112 D J 0.1660 Aggregation-prone
113 N J -0.0568 Soluble
114 A J 0.0000 Buried
115 M J 0.0000 Buried
116 G J 0.0000 Buried
117 Y J -0.0892 Soluble
118 W J -0.5343 Soluble
119 G J -0.8076 Soluble
120 Q J -1.6539 Soluble
121 G J -1.0227 Soluble
122 T J -0.6046 Soluble
123 S J -0.3202 Soluble
124 V J 0.0000 Buried
125 T J 0.4511 Aggregation-prone
126 V J 0.0000 Buried
127 S J -0.0961 Soluble
1 D I -0.9782 Soluble
2 I I 0.2868 Aggregation-prone
3 V I 1.1255 Aggregation-prone
4 M I 0.0000 Buried
5 T I 0.2341 Aggregation-prone
6 Q I 0.0000 Buried
7 S I 0.0097 Aggregation-prone
8 P I 0.2559 Aggregation-prone
9 L I 0.7477 Aggregation-prone
10 S I -0.1916 Soluble
11 L I -0.1476 Soluble
12 S I -0.8893 Soluble
13 T I 0.0000 Buried
14 S I -0.4179 Soluble
15 V I 0.2125 Aggregation-prone
16 G I -1.1643 Soluble
17 D I -1.8673 Soluble
18 R I -2.6101 Soluble
19 V I 0.0000 Buried
20 S I -0.7421 Soluble
21 L I 0.0000 Buried
22 T I -0.6255 Soluble
23 C I 0.0000 Buried
24 K I -1.6026 Soluble
25 A I 0.0000 Buried
26 S I -0.9014 Soluble
27 Q I -1.7587 Soluble
28 N I -2.4443 Soluble
29 V I 0.0000 Buried
36 G I -1.4245 Soluble
37 T I -0.9421 Soluble
38 A I -0.3573 Soluble
39 V I 0.0000 Buried
40 A I 0.0000 Buried
41 W I 0.0000 Buried
42 Y I 0.0000 Buried
43 Q I -1.1085 Soluble
44 Q I -1.6095 Soluble
45 K I -1.8083 Soluble
46 P I -1.4662 Soluble
47 G I -1.3954 Soluble
48 Q I -2.0806 Soluble
49 S I -1.3585 Soluble
50 P I 0.0000 Buried
51 K I -1.0144 Soluble
52 L I 0.0000 Buried
53 L I 0.0000 Buried
54 I I 0.0000 Buried
55 Y I -0.4144 Soluble
56 S I -0.4233 Soluble
57 A I 0.0000 Buried
65 S I -1.0213 Soluble
66 N I -1.5838 Soluble
67 R I -1.6448 Soluble
68 Y I -0.8989 Soluble
69 T I -0.7459 Soluble
70 G I -0.8187 Soluble
71 V I 0.0000 Buried
72 P I -1.3107 Soluble
74 D I -2.3186 Soluble
75 R I -1.9521 Soluble
76 F I 0.0000 Buried
77 T I -1.0198 Soluble
78 G I -0.6953 Soluble
79 S I -0.8698 Soluble
80 G I -1.1737 Soluble
83 S I -1.3626 Soluble
84 G I -1.8300 Soluble
85 T I -2.2255 Soluble
86 D I -2.6820 Soluble
87 F I 0.0000 Buried
88 T I -0.7727 Soluble
89 L I 0.0000 Buried
90 T I -0.8345 Soluble
91 I I 0.0000 Buried
92 S I -1.9748 Soluble
93 N I -2.2901 Soluble
94 M I 0.0000 Buried
95 Q I -1.1472 Soluble
96 S I -1.1126 Soluble
97 E I -1.6396 Soluble
98 D I 0.0000 Buried
99 L I -0.8643 Soluble
100 A I 0.0000 Buried
101 D I -1.6731 Soluble
102 Y I 0.0000 Buried
103 F I 0.0000 Buried
104 C I 0.0000 Buried
105 Q I 0.0000 Buried
106 Q I 0.0000 Buried
107 Y I 0.0000 Buried
108 S I -0.4250 Soluble
109 S I 0.2079 Aggregation-prone
114 Y I 0.9704 Aggregation-prone
115 P I 0.2989 Aggregation-prone
116 L I 0.3349 Aggregation-prone
117 T I 0.0000 Buried
118 F I 0.3285 Aggregation-prone
119 G I 0.0000 Buried
120 A I 0.1806 Aggregation-prone
121 G I 0.0000 Buried
122 T I 0.0000 Buried
123 K I -1.3389 Soluble
124 L I 0.0000 Buried
125 E I -1.3976 Soluble
126 L I -0.8082 Soluble
127 R I -1.6549 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5997 3.1599 CSV PDB
4.5 -0.645 3.095 CSV PDB
5.0 -0.695 3.0187 CSV PDB
5.5 -0.7423 2.9377 CSV PDB
6.0 -0.7793 2.8552 CSV PDB
6.5 -0.8014 2.7723 CSV PDB
7.0 -0.8095 2.6895 CSV PDB
7.5 -0.8086 2.6076 CSV PDB
8.0 -0.8015 2.5285 CSV PDB
8.5 -0.7868 2.4569 CSV PDB
9.0 -0.7617 2.4018 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH