Zinlirvimab / 6okp

A4DAB308_6okp_K_L | Source PDB: 6okp | Chains: K, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5672
Max Score
2.6986
Min Score
-3.819
Total Score
-131.03
Score CDR
-0.402
Score non-CDR
-0.6278

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGAT input.pdb
Selected Chain(s) K (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.819
Maximum Score 2.6986
Average Score -0.5672
Total Score -131.0254

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q K -1.5155 Soluble
2 V K -1.0817 Soluble
3 Q K -1.8771 Soluble
4 L K 0.0000 Buried
5 Q K -1.7679 Soluble
6 E K 0.0000 Buried
7 S K -0.6695 Soluble
8 G K -0.4223 Soluble
9 P K 0.0696 Aggregation-prone
11 G K 0.4683 Aggregation-prone
12 L K 1.1645 Aggregation-prone
13 V K -0.1758 Soluble
14 K K -1.8545 Soluble
15 P K -1.5633 Soluble
16 S K -1.7564 Soluble
17 E K -2.5982 Soluble
18 T K -1.7522 Soluble
19 L K 0.0000 Buried
20 S K -0.4777 Soluble
21 V K 0.0000 Buried
22 T K -0.6470 Soluble
23 C K 0.0000 Buried
24 S K -1.1354 Soluble
25 V K 0.0000 Buried
26 S K -1.5167 Soluble
27 G K -1.3713 Soluble
28 D K -1.5457 Soluble
29 S K -1.4814 Soluble
30 M K 0.0000 Buried
35 N K -2.6742 Soluble
36 N K -2.1960 Soluble
37 Y K -1.5357 Soluble
38 Y K -1.3589 Soluble
39 W K 0.0000 Buried
40 T K 0.0000 Buried
41 W K 0.0000 Buried
42 I K 0.0000 Buried
43 R K -0.3000 Soluble
44 Q K 0.0000 Buried
45 S K -0.8200 Soluble
46 P K -1.0106 Soluble
47 G K -1.4466 Soluble
48 K K -2.2004 Soluble
49 G K -1.3657 Soluble
50 L K 0.0000 Buried
51 E K -0.6495 Soluble
52 W K 0.0000 Buried
53 I K 0.0000 Buried
54 G K 0.0000 Buried
55 Y K 0.0255 Aggregation-prone
56 I K 0.0000 Buried
57 S K -2.3178 Soluble
58 D K -3.8190 Soluble
59 R K -3.7919 Soluble
63 E K -3.2963 Soluble
64 S K -1.9440 Soluble
65 A K -0.6377 Soluble
66 T K -0.1566 Soluble
67 Y K 0.1099 Aggregation-prone
68 N K 0.0000 Buried
69 P K -0.8838 Soluble
70 S K -0.8122 Soluble
71 L K 0.0000 Buried
72 N K -1.6549 Soluble
74 S K -0.8858 Soluble
75 R K -0.9698 Soluble
76 V K 0.0000 Buried
77 V K 1.1375 Aggregation-prone
78 I K 0.0000 Buried
79 S K -0.2507 Soluble
80 R K -0.9767 Soluble
81 D K -1.3584 Soluble
82 T K -1.4008 Soluble
83 S K -1.3760 Soluble
84 K K -2.2153 Soluble
85 N K -1.8551 Soluble
86 Q K -1.3943 Soluble
87 L K 0.0000 Buried
88 S K -0.4714 Soluble
89 L K 0.0000 Buried
90 K K -0.4768 Soluble
91 L K 0.0000 Buried
92 N K -1.4560 Soluble
93 S K -1.6470 Soluble
94 V K 0.0000 Buried
95 T K -0.8071 Soluble
96 P K -0.5588 Soluble
97 A K -0.1002 Soluble
98 D K 0.0000 Buried
99 T K 0.0558 Aggregation-prone
100 A K 0.0000 Buried
101 V K 0.1727 Aggregation-prone
102 Y K 0.0000 Buried
103 Y K 0.0000 Buried
104 C K 0.0000 Buried
105 A K 0.0000 Buried
106 T K 0.0000 Buried
107 A K 0.0000 Buried
108 R K -2.6124 Soluble
109 R K -2.6371 Soluble
110 G K -1.4715 Soluble
111 Q K -0.6340 Soluble
111A R K 0.0560 Aggregation-prone
111B I K 1.3536 Aggregation-prone
111C Y K 1.3743 Aggregation-prone
111D G K 1.4583 Aggregation-prone
111E V K 2.6986 Aggregation-prone
111F V K 2.6569 Aggregation-prone
112G S K 1.6096 Aggregation-prone
112F F K 2.2554 Aggregation-prone
112E G K 1.0666 Aggregation-prone
112D E K 0.7537 Aggregation-prone
112C F K 1.2199 Aggregation-prone
112B F K 0.6929 Aggregation-prone
112A Y K 0.4489 Aggregation-prone
112 Y K -0.3152 Soluble
113 Y K -0.8464 Soluble
114 S K -0.9050 Soluble
115 M K 0.0000 Buried
116 D K -0.3367 Soluble
117 V K 0.0825 Aggregation-prone
118 W K -0.2661 Soluble
119 G K 0.0000 Buried
120 K K -2.3749 Soluble
121 G K -1.4174 Soluble
122 T K -0.6643 Soluble
123 T K 0.1032 Aggregation-prone
124 V K 0.0000 Buried
125 T K 0.2276 Aggregation-prone
126 V K 0.0000 Buried
127 S K -0.3913 Soluble
128 S K -0.5778 Soluble
129 A K -0.1374 Soluble
11 L L 1.1582 Aggregation-prone
12 S L 0.6027 Aggregation-prone
13 V L 0.9065 Aggregation-prone
14 A L 0.5685 Aggregation-prone
15 L L 0.4942 Aggregation-prone
16 G L -0.8514 Soluble
17 E L -1.7376 Soluble
18 T L -1.1037 Soluble
19 A L 0.0000 Buried
20 R L -1.5784 Soluble
21 I L -0.4773 Soluble
22 S L -1.1695 Soluble
23 C L 0.0000 Buried
24 G L -2.0964 Soluble
25 R L -3.0362 Soluble
26 Q L -2.3936 Soluble
27 A L 0.0000 Buried
28 L L 0.1838 Aggregation-prone
29 G L 0.0956 Aggregation-prone
36 S L 0.1466 Aggregation-prone
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 H L -1.1342 Soluble
45 R L -1.8862 Soluble
46 P L -1.6431 Soluble
47 G L -1.3922 Soluble
48 Q L -1.9671 Soluble
49 A L -1.1129 Soluble
50 P L 0.0000 Buried
51 I L 0.5530 Aggregation-prone
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.4527 Soluble
56 N L -1.2085 Soluble
57 N L -1.3713 Soluble
65 Q L -1.7821 Soluble
66 D L -1.3552 Soluble
67 R L -1.3388 Soluble
68 P L -0.5310 Soluble
69 S L -0.4886 Soluble
70 G L -0.6960 Soluble
71 I L -0.5749 Soluble
72 P L -1.1857 Soluble
74 E L -2.1497 Soluble
75 R L -1.4830 Soluble
76 F L 0.0000 Buried
77 S L -1.3991 Soluble
78 G L -1.0253 Soluble
79 T L -0.9283 Soluble
80 P L -0.8045 Soluble
81 D L -0.4681 Soluble
81A I L 1.6283 Aggregation-prone
82 N L 0.0000 Buried
83 F L 1.7892 Aggregation-prone
84 G L -0.1067 Soluble
85 T L -1.0235 Soluble
86 R L -2.5897 Soluble
87 A L 0.0000 Buried
88 T L -1.0394 Soluble
89 L L 0.0000 Buried
90 T L -0.8918 Soluble
91 I L 0.0000 Buried
92 S L -1.4142 Soluble
93 G L -1.0594 Soluble
94 V L -1.1053 Soluble
95 E L -1.7736 Soluble
96 A L -0.9765 Soluble
97 G L -1.4656 Soluble
98 D L 0.0000 Buried
99 E L -2.3585 Soluble
100 A L -1.9329 Soluble
101 D L -1.5171 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 M L 0.1037 Aggregation-prone
107 W L 0.2938 Aggregation-prone
108 D L -0.4763 Soluble
109 S L -0.6668 Soluble
110 R L -1.7335 Soluble
112 S L -0.6901 Soluble
113 G L -0.1337 Soluble
114 F L 1.4504 Aggregation-prone
115 S L 0.8122 Aggregation-prone
116 W L 0.3472 Aggregation-prone
117 S L -0.2957 Soluble
118 F L 0.0000 Buried
119 G L -0.9774 Soluble
120 G L -1.1565 Soluble
121 A L -0.9081 Soluble
122 T L -0.4371 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4301 4.5913 CSV PDB
4.5 -0.4738 4.5364 CSV PDB
5.0 -0.5269 4.4765 CSV PDB
5.5 -0.5802 4.4148 CSV PDB
6.0 -0.625 4.3525 CSV PDB
6.5 -0.6544 4.2902 CSV PDB
7.0 -0.6669 4.2283 CSV PDB
7.5 -0.6676 4.1677 CSV PDB
8.0 -0.6615 4.1454 CSV PDB
8.5 -0.6507 4.1443 CSV PDB
9.0 -0.6351 4.144 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH