Sonavibart / 5jw4

A4DAB244_5jw4_M_N | Source PDB: 5jw4 | Chains: M, N | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6602
Max Score
2.2357
Min Score
-3.6639
Total Score
-283.25
Score CDR
-0.0434
Score non-CDR
-0.7435

Calculation Parameters

Chain Sequence(s) QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFPLAPSSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPMTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) M (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6639
Maximum Score 2.2357
Average Score -0.6602
Total Score -283.2459

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.5722 Soluble
2 V M -1.4374 Soluble
3 Q M -1.9891 Soluble
4 L M 0.0000 Buried
5 Q M -1.7700 Soluble
6 Q M 0.0000 Buried
7 S M -0.7311 Soluble
8 G M -0.3270 Soluble
9 P M -0.4874 Soluble
11 G M -0.2661 Soluble
12 L M -0.2518 Soluble
13 V M 0.0000 Buried
14 K M -2.1278 Soluble
15 P M -1.5033 Soluble
16 S M -1.4977 Soluble
17 Q M -2.0656 Soluble
18 T M -1.4399 Soluble
19 L M 0.0000 Buried
20 S M -0.7211 Soluble
21 L M 0.0000 Buried
22 T M -0.6790 Soluble
23 C M 0.0000 Buried
24 A M -1.2096 Soluble
25 I M 0.0000 Buried
26 S M -1.3479 Soluble
27 G M -1.3143 Soluble
28 D M -1.2342 Soluble
29 S M -0.5018 Soluble
30 V M 0.0000 Buried
31 S M -0.0451 Soluble
34 S M 0.0216 Aggregation-prone
35 Y M 0.5324 Aggregation-prone
36 N M -0.8343 Soluble
37 A M 0.0000 Buried
38 V M 0.0000 Buried
39 W M 0.0000 Buried
40 N M 0.0000 Buried
41 W M 0.0000 Buried
42 I M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -0.5343 Soluble
45 S M -1.0354 Soluble
46 P M -0.8973 Soluble
47 S M -1.6286 Soluble
48 R M -2.5170 Soluble
49 G M -1.4937 Soluble
50 L M 0.0000 Buried
51 E M 0.0000 Buried
52 W M 0.0000 Buried
53 L M 0.0000 Buried
54 G M 0.0000 Buried
55 R M -0.6910 Soluble
56 T M 0.0000 Buried
57 Y M 0.2414 Aggregation-prone
58 Y M 0.6071 Aggregation-prone
59 R M 0.1184 Aggregation-prone
60 S M 0.0126 Aggregation-prone
62 G M 0.1775 Aggregation-prone
63 W M 0.5581 Aggregation-prone
64 Y M 0.4395 Aggregation-prone
65 N M -0.6155 Soluble
66 D M -1.2462 Soluble
67 Y M -1.4413 Soluble
68 A M 0.0000 Buried
69 E M -2.5570 Soluble
70 S M -1.5956 Soluble
71 V M 0.0000 Buried
72 K M -2.6292 Soluble
74 S M -1.6046 Soluble
75 R M -1.3240 Soluble
76 I M 0.0000 Buried
77 T M -1.1696 Soluble
78 I M 0.0000 Buried
79 N M -1.4927 Soluble
80 P M -1.1471 Soluble
81 D M -1.5352 Soluble
82 T M -1.2436 Soluble
83 S M -1.3468 Soluble
84 K M -2.1806 Soluble
85 N M -1.6066 Soluble
86 Q M -1.4983 Soluble
87 F M 0.0000 Buried
88 S M -0.8420 Soluble
89 L M 0.0000 Buried
90 Q M -0.9669 Soluble
91 L M 0.0000 Buried
92 N M -1.3432 Soluble
93 S M -1.3206 Soluble
94 V M 0.0000 Buried
95 T M -1.3727 Soluble
96 P M -1.3938 Soluble
97 E M -2.2188 Soluble
98 D M 0.0000 Buried
99 T M -0.5771 Soluble
100 A M 0.0000 Buried
101 V M 0.2915 Aggregation-prone
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 R M 0.0000 Buried
107 S M 0.0000 Buried
108 G M 0.0000 Buried
109 H M -0.7180 Soluble
110 I M 0.1013 Aggregation-prone
111 T M 0.7157 Aggregation-prone
111A V M 1.5116 Aggregation-prone
111B F M 2.2357 Aggregation-prone
112C G M 0.9116 Aggregation-prone
112B V M 1.4009 Aggregation-prone
112A N M 0.2872 Aggregation-prone
112 V M 0.0000 Buried
113 D M 0.0000 Buried
114 A M 0.0000 Buried
115 F M 0.0000 Buried
116 D M -0.6587 Soluble
117 M M -0.7551 Soluble
118 W M 0.0000 Buried
119 G M 0.0000 Buried
120 Q M -1.9490 Soluble
121 G M -0.9809 Soluble
122 T M 0.0000 Buried
123 M M 0.1604 Aggregation-prone
124 V M 0.0000 Buried
125 T M -0.4134 Soluble
126 V M 0.0000 Buried
127 S M -0.7460 Soluble
128 S M -0.8246 Soluble
129 A M -0.5301 Soluble
130 S M -0.6619 Soluble
131 T M -0.7935 Soluble
132 K M -1.2804 Soluble
133 G M -1.4238 Soluble
134 P M -0.6376 Soluble
135 S M -0.2946 Soluble
136 V M 0.0000 Buried
137 F M 0.0000 Buried
138 P M -1.0880 Soluble
139 L M 0.0000 Buried
140 A M -0.8267 Soluble
141 P M 0.0000 Buried
142 S M -0.5551 Soluble
143 S M -0.4172 Soluble
144 G M -0.6657 Soluble
145 T M -0.4992 Soluble
146 A M 0.0000 Buried
147 A M 0.0000 Buried
148 L M 0.0000 Buried
149 G M 0.0000 Buried
150 C M 0.0000 Buried
151 L M 0.0000 Buried
152 V M 0.0000 Buried
153 K M 0.0000 Buried
154 D M -0.4168 Soluble
155 Y M 0.0000 Buried
156 F M 0.0000 Buried
157 P M 0.0000 Buried
158 E M -0.3739 Soluble
159 P M -0.6594 Soluble
160 V M -0.6906 Soluble
161 T M -0.6205 Soluble
162 V M -0.4239 Soluble
163 S M -0.4215 Soluble
164 W M 0.0000 Buried
165 N M -0.7174 Soluble
166 S M -0.6562 Soluble
167 G M -0.5663 Soluble
168 A M -0.2374 Soluble
169 L M 0.0209 Aggregation-prone
170 T M -0.1657 Soluble
171 S M -0.1777 Soluble
172 G M -0.1979 Soluble
173 V M 0.1709 Aggregation-prone
174 H M -0.2916 Soluble
175 T M 0.0081 Aggregation-prone
176 F M 0.0000 Buried
177 P M -0.2352 Soluble
178 A M 0.2893 Aggregation-prone
179 V M 0.6711 Aggregation-prone
180 L M 1.2611 Aggregation-prone
181 Q M 0.3421 Aggregation-prone
182 S M -0.2025 Soluble
183 S M -0.2052 Soluble
184 G M 0.0520 Aggregation-prone
185 L M 0.1938 Aggregation-prone
186 Y M 0.4754 Aggregation-prone
187 S M 0.0000 Buried
188 L M 0.0000 Buried
189 S M 0.0000 Buried
190 S M 0.0000 Buried
191 V M 0.0000 Buried
192 V M 0.0000 Buried
193 T M -0.1314 Soluble
194 V M 0.0000 Buried
195 P M -0.4886 Soluble
196 S M -0.5448 Soluble
197 S M -0.6053 Soluble
198 S M -0.6143 Soluble
199 L M -0.7826 Soluble
200 G M -0.9219 Soluble
201 T M -0.6791 Soluble
202 Q M -1.1002 Soluble
203 T M -1.0242 Soluble
204 Y M 0.0000 Buried
205 I M -1.1775 Soluble
206 C M 0.0000 Buried
207 N M -1.5202 Soluble
208 V M 0.0000 Buried
209 N M -2.1069 Soluble
210 H M 0.0000 Buried
211 K M -2.8287 Soluble
212 P M -1.6720 Soluble
213 S M -1.8990 Soluble
214 N M -2.6138 Soluble
215 T M -2.1765 Soluble
216 K M -2.7614 Soluble
217 V M -1.6757 Soluble
218 D M -2.5454 Soluble
219 K M -1.9895 Soluble
220 K M -2.4750 Soluble
221 V M 0.0000 Buried
222 E M -2.4407 Soluble
223 P M -1.2201 Soluble
4 M N -0.8192 Soluble
5 T N -1.0067 Soluble
6 Q N 0.0000 Buried
7 S N -0.7614 Soluble
8 P N -0.4514 Soluble
9 S N -0.7744 Soluble
10 S N -0.6649 Soluble
11 L N -0.4277 Soluble
12 S N -0.7571 Soluble
13 A N -1.0200 Soluble
14 S N -0.9875 Soluble
15 V N -0.2829 Soluble
16 G N -0.9695 Soluble
17 D N -1.9734 Soluble
18 R N -2.3884 Soluble
19 V N 0.0000 Buried
20 T N -0.6277 Soluble
21 I N 0.0000 Buried
22 T N -0.7588 Soluble
23 C N 0.0000 Buried
24 R N -2.3829 Soluble
25 T N 0.0000 Buried
26 S N -1.2201 Soluble
27 Q N -1.6502 Soluble
28 S N -1.1436 Soluble
29 L N -0.1554 Soluble
36 S N -0.3221 Soluble
37 S N 0.3096 Aggregation-prone
38 Y N 0.3388 Aggregation-prone
39 T N 0.0000 Buried
40 H N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N 0.0000 Buried
44 Q N -1.3203 Soluble
45 K N -1.7957 Soluble
46 P N -1.4711 Soluble
47 G N -1.6602 Soluble
48 K N -2.5892 Soluble
49 A N -1.6605 Soluble
50 P N 0.0000 Buried
51 K N -1.6476 Soluble
52 L N 0.0000 Buried
53 L N 0.0000 Buried
54 I N 0.0000 Buried
55 Y N -0.0983 Soluble
56 A N 0.0196 Aggregation-prone
57 A N 0.0000 Buried
65 S N -0.6953 Soluble
66 S N -0.8131 Soluble
67 R N -1.6133 Soluble
68 G N 0.0000 Buried
69 S N -0.9702 Soluble
70 G N -0.9594 Soluble
71 V N 0.0000 Buried
72 P N -0.7182 Soluble
74 S N -0.7732 Soluble
75 R N -0.9692 Soluble
76 F N 0.0000 Buried
77 S N -0.7502 Soluble
78 G N -0.5649 Soluble
79 S N -0.5991 Soluble
80 G N -0.9820 Soluble
83 S N -0.9854 Soluble
84 G N -1.2149 Soluble
85 T N -1.5245 Soluble
86 D N -1.7015 Soluble
87 F N 0.0000 Buried
88 T N -0.6484 Soluble
89 L N 0.0000 Buried
90 T N -0.6081 Soluble
91 I N 0.0000 Buried
92 S N -1.3557 Soluble
93 S N -1.2486 Soluble
94 L N 0.0000 Buried
95 Q N -0.9430 Soluble
96 P N -1.5323 Soluble
97 E N -1.7853 Soluble
98 D N 0.0000 Buried
99 F N 0.0000 Buried
100 A N 0.0000 Buried
101 T N -0.8074 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 Q N 0.0000 Buried
106 Q N 0.0000 Buried
107 S N -0.4710 Soluble
116 R N -1.0508 Soluble
117 T N -0.5898 Soluble
118 F N -0.3470 Soluble
119 G N 0.0000 Buried
120 Q N -1.6037 Soluble
121 G N 0.0000 Buried
122 T N 0.0000 Buried
123 K N -1.2030 Soluble
124 V N 0.0000 Buried
125 E N -1.2380 Soluble
126 I N 0.0000 Buried
127 K N -1.1596 Soluble
128 R N -0.8179 Soluble
129 T N 0.0216 Aggregation-prone
130 V N 0.6460 Aggregation-prone
131 A N 0.2924 Aggregation-prone
132 A N -0.0208 Soluble
133 P N 0.0000 Buried
134 S N -0.1230 Soluble
135 V N 0.0000 Buried
136 F N 0.2163 Aggregation-prone
137 I N 0.1628 Aggregation-prone
138 F N 0.0000 Buried
139 P N -0.5351 Soluble
140 P N -0.8596 Soluble
141 S N -1.6086 Soluble
142 D N -2.8661 Soluble
143 E N -2.8344 Soluble
144 Q N 0.0000 Buried
145 L N -2.2347 Soluble
146 K N -2.7648 Soluble
147 S N -1.7198 Soluble
148 G N -1.2701 Soluble
149 T N -1.0389 Soluble
150 A N 0.0000 Buried
151 S N 0.0000 Buried
152 V N 0.0000 Buried
153 V N 0.0000 Buried
154 C N 0.0000 Buried
155 L N 0.0000 Buried
156 L N 0.0000 Buried
157 N N 0.0000 Buried
158 N N -0.7741 Soluble
159 F N 0.0000 Buried
160 Y N 0.0000 Buried
161 P N -1.6069 Soluble
162 R N -3.0623 Soluble
163 E N -3.2762 Soluble
164 A N -2.4176 Soluble
165 K N -2.5717 Soluble
166 V N 0.0000 Buried
167 Q N -0.8882 Soluble
168 W N 0.0000 Buried
169 K N -0.7179 Soluble
170 V N 0.0000 Buried
171 D N -2.0338 Soluble
172 N N -1.6829 Soluble
173 A N -0.4293 Soluble
174 L N 0.3973 Aggregation-prone
175 Q N -0.4937 Soluble
176 S N -0.7257 Soluble
177 G N -1.2262 Soluble
178 N N -1.4992 Soluble
179 S N -1.3368 Soluble
180 Q N -1.1536 Soluble
181 E N -1.3835 Soluble
182 S N -0.5628 Soluble
183 V N -0.6450 Soluble
184 T N -1.0274 Soluble
185 E N -1.9893 Soluble
186 Q N 0.0000 Buried
187 D N -1.9562 Soluble
188 S N -2.1515 Soluble
189 K N -2.4907 Soluble
190 D N -1.7525 Soluble
191 S N 0.0000 Buried
192 T N 0.0000 Buried
193 Y N 0.0000 Buried
194 S N 0.0000 Buried
195 L N 0.0000 Buried
196 S N 0.0000 Buried
197 S N 0.0000 Buried
198 T N -0.5976 Soluble
199 L N 0.0000 Buried
200 T N -0.6106 Soluble
201 L N -0.8584 Soluble
202 S N -1.2686 Soluble
203 K N -2.0823 Soluble
204 A N -1.9832 Soluble
205 D N -2.7099 Soluble
206 Y N 0.0000 Buried
207 E N -3.4571 Soluble
208 K N -3.6639 Soluble
209 H N -3.1255 Soluble
210 K N -3.0672 Soluble
211 V N -1.3484 Soluble
212 Y N 0.0000 Buried
213 A N 0.0000 Buried
214 C N 0.0000 Buried
215 E N -0.8153 Soluble
216 V N 0.0000 Buried
217 T N -1.3296 Soluble
218 H N 0.0000 Buried
219 Q N -1.7215 Soluble
220 G N -0.3503 Soluble
221 L N -0.2014 Soluble
222 S N -0.4603 Soluble
223 S N -0.4880 Soluble
224 P N -0.6285 Soluble
225 V N -0.1223 Soluble
226 T N -0.5237 Soluble
227 K N -0.6325 Soluble
228 S N -0.4994 Soluble
229 F N -0.8718 Soluble
230 N N -1.7911 Soluble
231 R N -2.4921 Soluble
232 G N -2.1369 Soluble
233 E N -2.4650 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7653 4.7013 CSV PDB
4.5 -0.7995 4.7013 CSV PDB
5.0 -0.8387 4.7013 CSV PDB
5.5 -0.874 4.7013 CSV PDB
6.0 -0.8956 4.7013 CSV PDB
6.5 -0.8962 4.7013 CSV PDB
7.0 -0.8769 4.7013 CSV PDB
7.5 -0.8451 4.7013 CSV PDB
8.0 -0.807 4.7013 CSV PDB
8.5 -0.7646 4.7013 CSV PDB
9.0 -0.7179 4.7013 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH