Zinlirvimab / 7ugo

A4DAB308_7ugo_N_Q | Source PDB: 7ugo | Chains: N, Q | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6202
Max Score
2.916
Min Score
-3.6436
Total Score
-146.98
Score CDR
-0.4268
Score non-CDR
-0.6887

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) N (Heavy), Q (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6436
Maximum Score 2.916
Average Score -0.6202
Total Score -146.9818

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q N -1.7807 Soluble
2 V N -1.4418 Soluble
3 Q N -1.9970 Soluble
4 L N 0.0000 Buried
5 Q N -2.0800 Soluble
6 E N -1.3747 Soluble
7 S N -0.8627 Soluble
8 G N -0.4342 Soluble
9 P N 0.0124 Aggregation-prone
11 G N 0.5024 Aggregation-prone
12 L N 1.1275 Aggregation-prone
13 V N -0.3233 Soluble
14 K N -1.8456 Soluble
15 P N -1.6650 Soluble
16 S N -1.9458 Soluble
17 E N -2.8240 Soluble
18 T N -1.8418 Soluble
19 L N 0.0000 Buried
20 S N -0.8637 Soluble
21 V N 0.0000 Buried
22 T N -0.6566 Soluble
23 C N 0.0000 Buried
24 S N -1.1079 Soluble
25 V N -1.0035 Soluble
26 S N -1.4843 Soluble
27 G N -1.9031 Soluble
28 D N -2.5563 Soluble
29 S N -1.5643 Soluble
30 M N -1.2424 Soluble
35 N N -2.1604 Soluble
36 N N -2.0715 Soluble
37 Y N -0.9483 Soluble
38 Y N -0.6456 Soluble
39 W N 0.0000 Buried
40 T N 0.0000 Buried
41 W N 0.0000 Buried
42 I N 0.0000 Buried
43 R N -0.7740 Soluble
44 Q N -1.0748 Soluble
45 S N -1.2145 Soluble
46 P N -1.1100 Soluble
47 G N -1.5206 Soluble
48 K N -2.3505 Soluble
49 G N -1.6890 Soluble
50 L N 0.0000 Buried
51 E N -0.9964 Soluble
52 W N 0.0000 Buried
53 I N 0.0000 Buried
54 G N 0.0000 Buried
55 Y N 0.1992 Aggregation-prone
56 I N 0.0000 Buried
57 S N -2.1144 Soluble
58 D N -3.6436 Soluble
59 R N -3.6352 Soluble
63 E N -3.4247 Soluble
64 S N -1.9260 Soluble
65 A N -0.4341 Soluble
66 T N -0.0524 Soluble
67 Y N -0.0879 Soluble
68 N N -0.5201 Soluble
69 P N -0.6518 Soluble
70 S N -0.6760 Soluble
71 L N -0.8855 Soluble
72 N N -1.6760 Soluble
74 S N -1.0509 Soluble
75 R N -1.4309 Soluble
76 V N 0.0000 Buried
77 V N 0.6338 Aggregation-prone
78 I N 0.0000 Buried
79 S N -0.8936 Soluble
80 R N -2.1881 Soluble
81 D N -2.4896 Soluble
82 T N -1.8191 Soluble
83 S N -1.8246 Soluble
84 K N -2.6841 Soluble
85 N N -2.2518 Soluble
86 Q N -1.6892 Soluble
87 L N 0.0000 Buried
88 S N -0.5537 Soluble
89 L N 0.0000 Buried
90 K N -1.1698 Soluble
91 L N -1.2438 Soluble
92 N N -2.1854 Soluble
93 S N -1.4531 Soluble
94 V N 0.0000 Buried
95 T N -0.9985 Soluble
96 P N -0.7209 Soluble
97 A N -0.3841 Soluble
98 D N -0.7619 Soluble
99 T N -0.3013 Soluble
100 A N 0.0000 Buried
101 V N -0.3519 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 A N 0.0000 Buried
106 T N 0.0000 Buried
107 A N 0.0000 Buried
108 R N -1.2487 Soluble
109 R N -1.1760 Soluble
110 G N -1.2469 Soluble
111 Q N -1.0911 Soluble
111A R N -0.9042 Soluble
111B I N 1.0503 Aggregation-prone
111C Y N 1.2542 Aggregation-prone
111D G N 1.2985 Aggregation-prone
111E V N 2.5742 Aggregation-prone
111F V N 2.9160 Aggregation-prone
112G S N 1.7889 Aggregation-prone
112F F N 2.4513 Aggregation-prone
112E G N 1.5266 Aggregation-prone
112D E N 1.1172 Aggregation-prone
112C F N 1.3003 Aggregation-prone
112B F N 0.4259 Aggregation-prone
112A Y N 0.4042 Aggregation-prone
112 Y N 0.0000 Buried
113 Y N 0.0000 Buried
114 S N -0.5557 Soluble
115 M N 0.0000 Buried
116 D N 0.0625 Aggregation-prone
117 V N 0.3117 Aggregation-prone
118 W N 0.0000 Buried
119 G N 0.0000 Buried
120 K N -2.4641 Soluble
121 G N -1.4854 Soluble
122 T N -0.7332 Soluble
123 T N -0.0082 Soluble
124 V N 0.0000 Buried
125 T N 0.0890 Aggregation-prone
126 V N 0.0000 Buried
127 S N -0.5332 Soluble
128 S N -0.6693 Soluble
129 A N -0.2008 Soluble
11 L Q 0.8580 Aggregation-prone
12 S Q 0.8473 Aggregation-prone
13 V Q 0.5143 Aggregation-prone
14 A Q 0.8187 Aggregation-prone
15 L Q 0.3624 Aggregation-prone
16 G Q -0.8903 Soluble
17 E Q -1.4802 Soluble
18 T Q -1.2375 Soluble
19 A Q 0.0000 Buried
20 R Q -1.8636 Soluble
21 I Q 0.0000 Buried
22 S Q -1.1692 Soluble
23 C Q 0.0000 Buried
24 G Q -1.8590 Soluble
25 R Q -2.6280 Soluble
26 Q Q -2.0736 Soluble
27 A Q -0.9036 Soluble
28 L Q 0.5954 Aggregation-prone
29 G Q 0.3170 Aggregation-prone
36 S Q 0.5028 Aggregation-prone
37 R Q -0.4247 Soluble
38 A Q 0.0000 Buried
39 V Q 0.0000 Buried
40 Q Q 0.0000 Buried
41 W Q 0.0000 Buried
42 Y Q 0.0000 Buried
43 Q Q -0.3358 Soluble
44 H Q 0.0000 Buried
45 R Q -1.7928 Soluble
46 P Q -1.3890 Soluble
47 G Q -1.6188 Soluble
48 Q Q -1.9055 Soluble
49 A Q -0.9054 Soluble
50 P Q 0.0000 Buried
51 I Q 1.6145 Aggregation-prone
52 L Q 0.0000 Buried
53 L Q 0.0000 Buried
54 I Q 0.0000 Buried
55 Y Q -1.0084 Soluble
56 N Q -1.8476 Soluble
57 N Q -1.6058 Soluble
65 Q Q -2.2836 Soluble
66 D Q -2.2118 Soluble
67 R Q -1.7189 Soluble
68 P Q -0.9620 Soluble
69 S Q -0.6018 Soluble
70 G Q -0.6682 Soluble
71 I Q -0.5569 Soluble
72 P Q -1.1926 Soluble
74 E Q -2.2273 Soluble
75 R Q -1.6055 Soluble
76 F Q 0.0000 Buried
77 S Q -1.1882 Soluble
78 G Q -1.0777 Soluble
79 T Q -0.5845 Soluble
80 P Q -0.4743 Soluble
81 D Q 0.2026 Aggregation-prone
81A I Q 1.7100 Aggregation-prone
82 N Q 0.4360 Aggregation-prone
83 F Q 1.5861 Aggregation-prone
84 G Q 0.3679 Aggregation-prone
85 T Q -0.1258 Soluble
86 R Q -1.0750 Soluble
87 A Q 0.0000 Buried
88 T Q -0.8082 Soluble
89 L Q 0.0000 Buried
90 T Q -1.0793 Soluble
91 I Q 0.0000 Buried
92 S Q -1.5649 Soluble
93 G Q -1.3393 Soluble
94 V Q 0.0000 Buried
95 E Q -2.0474 Soluble
96 A Q -1.0665 Soluble
97 G Q -1.2505 Soluble
98 D Q -1.6083 Soluble
99 E Q -2.2417 Soluble
100 A Q 0.0000 Buried
101 D Q -1.5888 Soluble
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q -0.3748 Soluble
105 H Q 0.0000 Buried
106 M Q -0.4039 Soluble
107 W Q 0.0000 Buried
108 D Q -0.4993 Soluble
109 S Q -0.7680 Soluble
110 R Q -1.7444 Soluble
112 S Q -0.9864 Soluble
113 G Q -0.6155 Soluble
114 F Q 0.4040 Aggregation-prone
115 S Q 0.1475 Aggregation-prone
116 W Q 0.0572 Aggregation-prone
117 S Q -0.3923 Soluble
118 F Q 0.0000 Buried
119 G Q -1.1782 Soluble
120 G Q -1.3007 Soluble
121 A Q -1.0515 Soluble
122 T Q -0.8401 Soluble
123 R Q -1.7949 Soluble
124 L Q 0.0000 Buried
125 T Q 0.1067 Aggregation-prone
126 V Q 0.6175 Aggregation-prone
127 L Q 1.2964 Aggregation-prone
128 G Q 0.4927 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4789 4.6321 CSV PDB
4.5 -0.5238 4.616 CSV PDB
5.0 -0.5783 4.5973 CSV PDB
5.5 -0.6331 4.5774 CSV PDB
6.0 -0.6796 4.5571 CSV PDB
6.5 -0.7113 4.5366 CSV PDB
7.0 -0.7272 4.5162 CSV PDB
7.5 -0.7318 4.496 CSV PDB
8.0 -0.7296 4.4764 CSV PDB
8.5 -0.722 4.4585 CSV PDB
9.0 -0.7083 4.4445 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH