Zinlirvimab / 8czz

A4DAB308_8czz_Q_R | Source PDB: 8czz | Chains: Q, R | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.572
Max Score
2.3311
Min Score
-2.8573
Total Score
-134.41
Score CDR
-0.3633
Score non-CDR
-0.6467

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) Q (Heavy), R (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.8573
Maximum Score 2.3311
Average Score -0.572
Total Score -134.4131

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q Q -1.9031 Soluble
2 V Q -1.2042 Soluble
3 Q Q -1.9502 Soluble
4 L Q -1.3095 Soluble
5 Q Q -1.9774 Soluble
6 E Q -1.3567 Soluble
7 S Q -0.8091 Soluble
8 G Q -0.5700 Soluble
9 P Q -0.2452 Soluble
11 G Q 0.1647 Aggregation-prone
12 L Q 0.8990 Aggregation-prone
13 V Q 0.0000 Buried
14 K Q -1.9903 Soluble
15 P Q -1.5734 Soluble
16 S Q -1.6447 Soluble
17 E Q -2.4441 Soluble
18 T Q -1.4154 Soluble
19 L Q 0.0000 Buried
20 S Q -0.7838 Soluble
21 V Q 0.0000 Buried
22 T Q -0.7504 Soluble
23 C Q 0.0000 Buried
24 S Q -0.9930 Soluble
25 V Q -1.2981 Soluble
26 S Q -1.4920 Soluble
27 G Q -1.9519 Soluble
28 D Q -2.5212 Soluble
29 S Q -1.6407 Soluble
30 M Q -1.0552 Soluble
35 N Q -1.3743 Soluble
36 N Q -1.7873 Soluble
37 Y Q -0.9973 Soluble
38 Y Q -0.9986 Soluble
39 W Q 0.0000 Buried
40 T Q 0.0000 Buried
41 W Q 0.0000 Buried
42 I Q 0.0000 Buried
43 R Q 0.0000 Buried
44 Q Q -1.2672 Soluble
45 S Q 0.0000 Buried
46 P Q -1.2605 Soluble
47 G Q -1.6372 Soluble
48 K Q -2.4213 Soluble
49 G Q -1.8392 Soluble
50 L Q 0.0000 Buried
51 E Q -1.3475 Soluble
52 W Q 0.0000 Buried
53 I Q 0.0000 Buried
54 G Q 0.0000 Buried
55 Y Q 0.0000 Buried
56 I Q 0.0000 Buried
57 S Q -1.3904 Soluble
58 D Q -1.9787 Soluble
59 R Q -2.8521 Soluble
63 E Q -2.6477 Soluble
64 S Q -1.4771 Soluble
65 A Q -0.2899 Soluble
66 T Q 0.0358 Aggregation-prone
67 Y Q -0.1123 Soluble
68 N Q -0.6896 Soluble
69 P Q -0.7471 Soluble
70 S Q -0.7472 Soluble
71 L Q -0.8193 Soluble
72 N Q -1.5623 Soluble
74 S Q -0.8236 Soluble
75 R Q -0.7866 Soluble
76 V Q 0.0000 Buried
77 V Q 1.3436 Aggregation-prone
78 I Q 0.3880 Aggregation-prone
79 S Q -0.4508 Soluble
80 R Q -1.4527 Soluble
81 D Q -1.9397 Soluble
82 T Q -1.6815 Soluble
83 S Q -1.3720 Soluble
84 K Q -2.1931 Soluble
85 N Q 0.0000 Buried
86 Q Q -1.3956 Soluble
87 L Q 0.0000 Buried
88 S Q -0.6553 Soluble
89 L Q 0.0000 Buried
90 K Q -0.2894 Soluble
91 L Q 0.0000 Buried
92 N Q -1.2942 Soluble
93 S Q -1.1256 Soluble
94 V Q -0.5216 Soluble
95 T Q -0.2385 Soluble
96 P Q -0.1629 Soluble
97 A Q -0.0036 Soluble
98 D Q 0.0000 Buried
99 T Q 0.0063 Aggregation-prone
100 A Q 0.0000 Buried
101 V Q 0.0000 Buried
102 Y Q 0.0000 Buried
103 Y Q 0.0000 Buried
104 C Q 0.0000 Buried
105 A Q 0.0000 Buried
106 T Q 0.0000 Buried
107 A Q 0.0000 Buried
108 R Q -1.8043 Soluble
109 R Q -1.9119 Soluble
110 G Q -1.1595 Soluble
111 Q Q -0.5885 Soluble
111A R Q -0.0661 Soluble
111B I Q 1.3566 Aggregation-prone
111C Y Q 1.5228 Aggregation-prone
111D G Q 1.2848 Aggregation-prone
111E V Q 2.1134 Aggregation-prone
111F V Q 2.3311 Aggregation-prone
112G S Q 1.4566 Aggregation-prone
112F F Q 2.1872 Aggregation-prone
112E G Q 1.0838 Aggregation-prone
112D E Q 0.8785 Aggregation-prone
112C F Q 1.3178 Aggregation-prone
112B F Q 0.5212 Aggregation-prone
112A Y Q 0.1666 Aggregation-prone
112 Y Q 0.0000 Buried
113 Y Q -0.7465 Soluble
114 S Q 0.0000 Buried
115 M Q 0.0000 Buried
116 D Q -0.9305 Soluble
117 V Q -0.1972 Soluble
118 W Q 0.0000 Buried
119 G Q 0.0000 Buried
120 K Q -2.5746 Soluble
121 G Q -1.5868 Soluble
122 T Q -0.9987 Soluble
123 T Q -0.1365 Soluble
124 V Q 0.0000 Buried
125 T Q 0.2733 Aggregation-prone
126 V Q 0.1685 Aggregation-prone
127 S Q -0.1873 Soluble
11 L R 1.1813 Aggregation-prone
12 S R 0.4438 Aggregation-prone
13 V R 1.1723 Aggregation-prone
14 A R 0.8833 Aggregation-prone
15 L R 1.0792 Aggregation-prone
16 G R -0.4897 Soluble
17 E R -1.3163 Soluble
18 T R -0.9153 Soluble
19 A R -1.0931 Soluble
20 R R -1.7847 Soluble
21 I R -0.5911 Soluble
22 S R -1.1489 Soluble
23 C R -1.1326 Soluble
24 G R -1.4652 Soluble
25 R R -2.3235 Soluble
26 Q R -2.2470 Soluble
27 A R -1.1306 Soluble
28 L R -0.3553 Soluble
29 G R -0.1831 Soluble
36 S R 0.3965 Aggregation-prone
37 R R -0.3934 Soluble
38 A R 0.0000 Buried
39 V R 0.0000 Buried
40 Q R 0.0000 Buried
41 W R 0.0000 Buried
42 Y R 0.0000 Buried
43 Q R -0.1659 Soluble
44 H R -0.8684 Soluble
45 R R -1.0745 Soluble
46 P R -1.0816 Soluble
47 G R -1.5935 Soluble
48 Q R -1.8786 Soluble
49 A R -1.1116 Soluble
50 P R -0.3572 Soluble
51 I R 0.7025 Aggregation-prone
52 L R 0.4379 Aggregation-prone
53 L R 0.0000 Buried
54 I R 0.0000 Buried
55 Y R -0.8696 Soluble
56 N R -1.3632 Soluble
57 N R 0.0000 Buried
65 Q R -2.0671 Soluble
66 D R -2.3034 Soluble
67 R R -2.8573 Soluble
68 P R -1.3975 Soluble
69 S R -0.9274 Soluble
70 G R -0.9257 Soluble
71 I R -1.0118 Soluble
72 P R -1.5501 Soluble
74 E R -2.4539 Soluble
75 R R -1.6807 Soluble
76 F R 0.0000 Buried
77 S R -1.4340 Soluble
78 G R -0.8211 Soluble
79 T R -0.5201 Soluble
80 P R -0.4557 Soluble
81 D R -0.2560 Soluble
81A I R 1.4477 Aggregation-prone
82 N R 0.3231 Aggregation-prone
83 F R 1.2513 Aggregation-prone
84 G R -0.1713 Soluble
85 T R -0.8864 Soluble
86 R R -2.1547 Soluble
87 A R -1.2949 Soluble
88 T R -0.9398 Soluble
89 L R 0.0000 Buried
90 T R -1.1098 Soluble
91 I R 0.0000 Buried
92 S R -1.3036 Soluble
93 G R -1.0112 Soluble
94 V R -0.8975 Soluble
95 E R -1.8562 Soluble
96 A R -1.2405 Soluble
97 G R -1.2963 Soluble
98 D R -1.9177 Soluble
99 E R -2.6510 Soluble
100 A R 0.0000 Buried
101 D R 0.0000 Buried
102 Y R 0.0000 Buried
103 Y R -0.2682 Soluble
104 C R 0.0000 Buried
105 H R 0.0000 Buried
106 M R 0.0000 Buried
107 W R 0.0000 Buried
108 D R 0.0000 Buried
109 S R -0.6995 Soluble
110 R R -1.8531 Soluble
112 S R -0.9319 Soluble
113 G R -0.3682 Soluble
114 F R 0.6654 Aggregation-prone
115 S R 0.0000 Buried
116 W R 0.2418 Aggregation-prone
117 S R -0.3372 Soluble
118 F R 0.0000 Buried
119 G R -0.5729 Soluble
120 G R -1.0493 Soluble
121 A R -0.5682 Soluble
122 T R -0.7795 Soluble
123 R R -1.8788 Soluble
124 L R 0.0000 Buried
125 T R 0.0614 Aggregation-prone
126 V R 1.2138 Aggregation-prone
127 L R 1.9190 Aggregation-prone
128 G R 0.6992 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4097 4.3697 CSV PDB
4.5 -0.4459 4.3528 CSV PDB
5.0 -0.4937 4.3274 CSV PDB
5.5 -0.5448 4.2977 CSV PDB
6.0 -0.5904 4.2683 CSV PDB
6.5 -0.6234 4.2439 CSV PDB
7.0 -0.6407 4.2283 CSV PDB
7.5 -0.6455 4.221 CSV PDB
8.0 -0.6432 4.2183 CSV PDB
8.5 -0.6368 4.2174 CSV PDB
9.0 -0.6268 4.2171 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH