Nirsevimab / 5udd

A4DAB181_5udd_O_U | Source PDB: 5udd | Chains: O, U | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6583
Max Score
2.5601
Min Score
-3.4162
Total Score
-279.12
Score CDR
-0.129
Score non-CDR
-0.7339

Calculation Parameters

Chain Sequence(s) QVQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPDIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) O (Heavy), U (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4162
Maximum Score 2.5601
Average Score -0.6583
Total Score -279.1165

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.6504 Soluble
2 V O 0.0000 Buried
3 Q O -1.5468 Soluble
4 L O 0.0000 Buried
5 V O 0.5851 Aggregation-prone
6 Q O 0.0000 Buried
7 S O -0.1222 Soluble
8 G O -0.9967 Soluble
9 A O -0.9736 Soluble
11 E O -1.2366 Soluble
12 V O -0.8250 Soluble
13 K O -1.5465 Soluble
14 K O -2.3895 Soluble
15 P O -1.7673 Soluble
16 G O -1.4516 Soluble
17 S O -1.1834 Soluble
18 S O -0.8945 Soluble
19 V O 0.0000 Buried
20 M O 0.1242 Aggregation-prone
21 V O 0.0000 Buried
22 S O 0.0909 Aggregation-prone
23 C O 0.0000 Buried
24 Q O -0.1503 Soluble
25 A O 0.0000 Buried
26 S O -0.7134 Soluble
27 G O -0.8874 Soluble
28 G O -0.5188 Soluble
29 L O -0.2008 Soluble
30 L O 0.0000 Buried
35 E O -1.0478 Soluble
36 D O -0.0539 Soluble
37 Y O 0.1971 Aggregation-prone
38 I O 0.0000 Buried
39 I O 0.0000 Buried
40 N O 0.0000 Buried
41 W O 0.0000 Buried
42 V O 0.0000 Buried
43 R O -0.4916 Soluble
44 Q O -0.7537 Soluble
45 A O -1.0751 Soluble
46 P O -0.8842 Soluble
47 G O -1.2304 Soluble
48 Q O -1.7704 Soluble
49 G O -1.1281 Soluble
50 P O 0.0000 Buried
51 E O -0.6548 Soluble
52 W O 0.0000 Buried
53 M O 0.0000 Buried
54 G O 0.0000 Buried
55 G O 0.0000 Buried
56 I O 0.0000 Buried
57 I O 0.0000 Buried
58 P O -0.3278 Soluble
59 V O 0.2681 Aggregation-prone
62 L O 0.2316 Aggregation-prone
63 G O 0.0116 Aggregation-prone
64 T O 0.4548 Aggregation-prone
65 V O 0.7964 Aggregation-prone
66 H O 0.3231 Aggregation-prone
67 Y O -0.2929 Soluble
68 G O 0.0000 Buried
69 P O -1.6122 Soluble
70 K O -2.2109 Soluble
71 F O 0.0000 Buried
72 Q O -1.9929 Soluble
74 G O -1.4414 Soluble
75 R O -1.3287 Soluble
76 V O 0.0000 Buried
77 T O -0.4906 Soluble
78 I O 0.0000 Buried
79 T O -0.3492 Soluble
80 A O -1.0572 Soluble
81 D O -1.8807 Soluble
82 E O -2.3967 Soluble
83 S O -1.3041 Soluble
84 T O -1.0174 Soluble
85 D O -1.2977 Soluble
86 T O 0.0000 Buried
87 A O 0.0000 Buried
88 Y O 0.0093 Aggregation-prone
89 M O 0.0000 Buried
90 E O -0.6675 Soluble
91 L O 0.0000 Buried
92 S O -0.7401 Soluble
93 S O -0.9223 Soluble
94 L O 0.0000 Buried
95 R O -2.1700 Soluble
96 S O -1.6623 Soluble
97 E O -2.1955 Soluble
98 D O 0.0000 Buried
99 T O -0.8178 Soluble
100 A O 0.0000 Buried
101 M O -0.0736 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 E O 0.0000 Buried
108 T O 0.3147 Aggregation-prone
109 A O 0.0000 Buried
110 L O 2.2187 Aggregation-prone
111 V O 2.5601 Aggregation-prone
111A V O 1.3169 Aggregation-prone
111B S O -0.1181 Soluble
111C E O -1.5683 Soluble
112C T O -0.6545 Soluble
112B Y O -0.0372 Soluble
112A L O 0.1647 Aggregation-prone
112 P O 0.0000 Buried
113 H O 0.0649 Aggregation-prone
114 Y O 0.2271 Aggregation-prone
115 F O 0.0000 Buried
116 D O -1.0196 Soluble
117 N O -1.1231 Soluble
118 W O 0.0000 Buried
119 G O 0.0000 Buried
120 Q O -1.4769 Soluble
121 G O -0.8095 Soluble
122 T O 0.0000 Buried
123 L O -0.1987 Soluble
124 V O 0.0000 Buried
125 T O 0.0000 Buried
126 V O 0.0000 Buried
127 S O -1.0984 Soluble
128 S O -0.9740 Soluble
129 T O -0.5715 Soluble
130 K O -1.0743 Soluble
131 G O -1.2652 Soluble
132 P O 0.0000 Buried
133 S O -0.5713 Soluble
134 V O 0.0000 Buried
135 F O 0.0000 Buried
136 P O -1.2867 Soluble
137 L O 0.0000 Buried
138 A O -0.7275 Soluble
139 P O -0.4881 Soluble
140 T O -0.2461 Soluble
141 A O -0.1391 Soluble
142 A O 0.0000 Buried
143 L O 0.0000 Buried
144 G O 0.0000 Buried
145 C O 0.0000 Buried
146 L O 0.0000 Buried
147 V O 0.0000 Buried
148 K O 0.0000 Buried
149 D O -0.2709 Soluble
150 Y O 0.0000 Buried
151 F O -0.2080 Soluble
152 P O 0.0000 Buried
153 E O -0.3863 Soluble
154 P O -0.6354 Soluble
155 V O 0.0000 Buried
156 T O -0.6337 Soluble
157 V O -0.4058 Soluble
158 S O -0.3760 Soluble
159 W O 0.0000 Buried
160 N O -0.4311 Soluble
161 S O -0.5399 Soluble
162 G O -0.6381 Soluble
163 A O -0.2762 Soluble
164 L O -0.0485 Soluble
165 T O -0.1815 Soluble
166 S O -0.3893 Soluble
167 G O -0.1571 Soluble
168 V O 0.1918 Aggregation-prone
169 H O 0.0000 Buried
170 T O -0.1350 Soluble
171 F O 0.0000 Buried
172 P O -0.4355 Soluble
173 A O 0.1659 Aggregation-prone
174 V O 0.3757 Aggregation-prone
175 L O 0.9697 Aggregation-prone
176 Q O 0.0000 Buried
177 S O -0.2390 Soluble
178 S O -0.2233 Soluble
179 G O -0.0297 Soluble
180 L O 0.1828 Aggregation-prone
181 Y O 0.4542 Aggregation-prone
182 S O 0.0000 Buried
183 L O 0.0000 Buried
184 S O 0.0000 Buried
185 S O 0.0000 Buried
186 V O 0.0000 Buried
187 V O 0.0000 Buried
188 T O -0.1554 Soluble
189 V O 0.0000 Buried
190 P O -0.3814 Soluble
191 S O -0.4138 Soluble
192 S O -0.5171 Soluble
193 S O -0.5487 Soluble
194 L O -0.5844 Soluble
195 G O -0.8491 Soluble
196 T O -0.6886 Soluble
197 Q O -0.9932 Soluble
198 T O -0.9840 Soluble
199 Y O 0.0000 Buried
200 I O -1.0347 Soluble
201 C O 0.0000 Buried
202 N O -1.3320 Soluble
203 V O 0.0000 Buried
204 N O -1.7378 Soluble
205 H O 0.0000 Buried
206 K O -2.8833 Soluble
207 P O -1.7608 Soluble
208 S O -1.7945 Soluble
209 N O -2.4679 Soluble
210 T O -2.0174 Soluble
211 K O -2.5737 Soluble
212 V O -1.5251 Soluble
213 D O -2.0323 Soluble
214 K O -2.1329 Soluble
215 R O -2.5631 Soluble
216 V O -1.8823 Soluble
217 E O -2.3272 Soluble
218 P O -1.1200 Soluble
1 D U -2.3485 Soluble
2 I U 0.0000 Buried
3 Q U -1.9529 Soluble
4 M U -1.2907 Soluble
5 T U -0.9682 Soluble
6 Q U -0.8500 Soluble
7 S U -0.7214 Soluble
8 P U -0.6688 Soluble
9 S U -0.9058 Soluble
10 S U -1.0103 Soluble
11 L U -0.6775 Soluble
12 S U -0.7533 Soluble
13 A U -0.7567 Soluble
14 A U -0.5418 Soluble
15 V U 0.3086 Aggregation-prone
16 G U -0.5601 Soluble
17 D U -1.6305 Soluble
18 R U -2.2925 Soluble
19 V U 0.0000 Buried
20 T U -0.6804 Soluble
21 I U 0.0000 Buried
22 T U -0.6548 Soluble
23 C U 0.0000 Buried
24 Q U -1.8849 Soluble
25 A U -1.7783 Soluble
26 S U -1.8856 Soluble
27 Q U -2.2417 Soluble
28 D U -2.2134 Soluble
29 I U 0.0000 Buried
36 V U 0.3541 Aggregation-prone
37 N U 0.0327 Aggregation-prone
38 Y U 0.3641 Aggregation-prone
39 L U 0.0000 Buried
40 N U 0.0000 Buried
41 W U 0.0000 Buried
42 Y U 0.0000 Buried
43 Q U 0.0000 Buried
44 Q U 0.0000 Buried
45 K U -1.7553 Soluble
46 P U -1.5537 Soluble
47 G U -1.8413 Soluble
48 K U -2.5301 Soluble
49 A U -1.6835 Soluble
50 P U 0.0000 Buried
51 K U -1.7920 Soluble
52 L U 0.0000 Buried
53 L U 0.0000 Buried
54 I U 0.0000 Buried
55 Y U 0.4556 Aggregation-prone
56 V U 0.6971 Aggregation-prone
57 A U 0.0000 Buried
65 S U -0.3610 Soluble
66 N U -0.3616 Soluble
67 L U -0.0232 Soluble
68 E U -0.6968 Soluble
69 T U -0.5007 Soluble
70 G U -0.5973 Soluble
71 V U 0.0000 Buried
72 P U -0.4453 Soluble
74 S U -0.4918 Soluble
75 R U -0.7312 Soluble
76 F U 0.0000 Buried
77 S U -0.4679 Soluble
78 G U -0.2966 Soluble
79 S U -0.7600 Soluble
80 G U -0.8175 Soluble
83 S U -0.7449 Soluble
84 G U -1.0547 Soluble
85 T U -1.7123 Soluble
86 D U -2.0507 Soluble
87 F U 0.0000 Buried
88 S U -0.6951 Soluble
89 L U 0.0000 Buried
90 T U -0.6082 Soluble
91 I U 0.0000 Buried
92 S U -1.3081 Soluble
93 S U -1.0203 Soluble
94 L U 0.0000 Buried
95 Q U -0.9591 Soluble
96 P U -1.7992 Soluble
97 E U -2.7869 Soluble
98 D U 0.0000 Buried
99 V U -1.5992 Soluble
100 A U 0.0000 Buried
101 T U -0.9681 Soluble
102 Y U 0.0000 Buried
103 Y U 0.0000 Buried
104 C U 0.0000 Buried
105 Q U 0.0000 Buried
106 Q U 0.0000 Buried
107 Y U -0.0885 Soluble
108 D U -1.0030 Soluble
109 N U -1.4719 Soluble
114 L U -0.6586 Soluble
115 P U -0.8297 Soluble
116 L U 0.0000 Buried
117 T U -0.6888 Soluble
118 F U -0.2063 Soluble
119 G U 0.0000 Buried
120 G U -1.0705 Soluble
121 G U 0.0000 Buried
122 T U 0.0000 Buried
123 K U -1.9207 Soluble
124 V U 0.0000 Buried
125 E U -0.9170 Soluble
126 I U -0.9574 Soluble
127 K U -1.3980 Soluble
128 A U -0.1287 Soluble
129 A U -0.1975 Soluble
130 P U -0.0623 Soluble
131 S U -0.0382 Soluble
132 V U 0.0000 Buried
133 F U 0.2766 Aggregation-prone
134 I U 0.1444 Aggregation-prone
135 F U 0.0000 Buried
136 P U -0.7586 Soluble
137 P U -0.9419 Soluble
138 S U -1.7772 Soluble
139 D U -3.0690 Soluble
140 E U -3.2285 Soluble
141 Q U 0.0000 Buried
142 L U -2.3365 Soluble
143 K U -2.8955 Soluble
144 S U -1.8199 Soluble
145 G U -1.5100 Soluble
146 T U -1.1644 Soluble
147 A U 0.0000 Buried
148 S U 0.0000 Buried
149 V U 0.0000 Buried
150 V U 0.0000 Buried
151 C U 0.0000 Buried
152 L U 0.0000 Buried
153 L U 0.0000 Buried
154 N U 0.0000 Buried
155 N U -0.6212 Soluble
156 F U 0.0000 Buried
157 Y U -0.6394 Soluble
158 P U -1.2933 Soluble
159 R U -2.0086 Soluble
160 E U -2.7977 Soluble
161 A U -2.0187 Soluble
162 K U -2.2706 Soluble
163 V U -1.0982 Soluble
164 Q U -0.6724 Soluble
165 W U 0.0000 Buried
166 K U -0.7704 Soluble
167 V U 0.0000 Buried
168 D U -1.9970 Soluble
169 N U -1.5584 Soluble
170 A U -0.5318 Soluble
171 L U 0.2030 Aggregation-prone
172 Q U -0.5224 Soluble
173 S U -0.7235 Soluble
174 G U -1.2680 Soluble
175 N U -1.5123 Soluble
176 S U -1.4338 Soluble
177 Q U -1.4682 Soluble
178 E U -1.9022 Soluble
179 S U 0.0000 Buried
180 V U -0.4308 Soluble
181 T U -0.9156 Soluble
182 E U -2.1134 Soluble
183 Q U 0.0000 Buried
184 D U -2.2329 Soluble
185 S U -2.5681 Soluble
186 K U -3.3315 Soluble
187 D U -3.0580 Soluble
188 S U 0.0000 Buried
189 T U 0.0000 Buried
190 Y U 0.0000 Buried
191 S U 0.0000 Buried
192 L U 0.0000 Buried
193 S U 0.0000 Buried
194 S U 0.0000 Buried
195 T U 0.0000 Buried
196 L U 0.0000 Buried
197 T U -0.3904 Soluble
198 L U -0.7051 Soluble
199 S U -1.1955 Soluble
200 K U -2.2663 Soluble
201 A U -1.9859 Soluble
202 D U -2.9684 Soluble
203 Y U 0.0000 Buried
204 E U -3.3548 Soluble
205 K U -3.4162 Soluble
206 H U -3.1669 Soluble
207 K U -3.4056 Soluble
208 V U -2.0093 Soluble
209 Y U 0.0000 Buried
210 A U -0.7786 Soluble
211 C U 0.0000 Buried
212 E U -0.5686 Soluble
213 V U 0.0000 Buried
214 T U -0.8743 Soluble
215 H U -1.3797 Soluble
216 Q U -1.6461 Soluble
217 G U -0.9467 Soluble
218 L U -0.4369 Soluble
219 S U -0.4758 Soluble
220 S U -0.3853 Soluble
221 P U -0.2783 Soluble
222 V U 0.1804 Aggregation-prone
223 T U -0.3491 Soluble
224 K U -0.6199 Soluble
225 S U -0.9488 Soluble
226 F U -1.2000 Soluble
227 N U -2.6009 Soluble
228 R U -3.1170 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5929 2.6409 CSV PDB
4.5 -0.6449 2.5809 CSV PDB
5.0 -0.7052 2.5036 CSV PDB
5.5 -0.7629 2.4195 CSV PDB
6.0 -0.8068 2.3363 CSV PDB
6.5 -0.8281 2.2647 CSV PDB
7.0 -0.8264 2.2395 CSV PDB
7.5 -0.8094 2.2144 CSV PDB
8.0 -0.7836 2.19 CSV PDB
8.5 -0.7509 2.1671 CSV PDB
9.0 -0.7108 2.148 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH