Danvilostomig / 5xj3

A4DAB080_5xj3_J_K | Source PDB: 5xj3 | Chains: J, K | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6031
Max Score
2.1737
Min Score
-3.4557
Total Score
-135.7
Score CDR
-0.1936
Score non-CDR
-0.7084

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK input.pdb
Selected Chain(s) J (Heavy), K (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4557
Maximum Score 2.1737
Average Score -0.6031
Total Score -135.7038

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q J -1.3214 Soluble
2 V J -0.6196 Soluble
3 Q J -0.9246 Soluble
4 L J 0.0000 Buried
5 V J 0.9062 Aggregation-prone
6 E J 0.0000 Buried
7 S J -0.3281 Soluble
8 G J -0.6701 Soluble
9 G J 0.0289 Aggregation-prone
11 G J 0.8474 Aggregation-prone
12 V J 1.6304 Aggregation-prone
13 V J 0.0000 Buried
14 Q J -1.3979 Soluble
15 P J -2.1363 Soluble
16 G J -2.1576 Soluble
17 R J -2.6692 Soluble
18 S J -2.0046 Soluble
19 L J -1.2991 Soluble
20 R J -2.1769 Soluble
21 L J 0.0000 Buried
22 S J -0.4954 Soluble
23 C J 0.0000 Buried
24 A J -0.1138 Soluble
25 A J 0.0000 Buried
26 S J -0.5737 Soluble
27 G J -0.6962 Soluble
28 F J -0.2697 Soluble
29 T J -0.1759 Soluble
30 F J 0.0000 Buried
35 S J -0.5803 Soluble
36 S J -0.0076 Soluble
37 Y J 0.0000 Buried
38 T J 0.0000 Buried
39 M J 0.0000 Buried
40 H J 0.0000 Buried
41 W J 0.0000 Buried
42 V J 0.0000 Buried
43 R J 0.0000 Buried
44 Q J -0.7340 Soluble
45 A J -1.0612 Soluble
46 P J -0.8392 Soluble
47 G J -1.4666 Soluble
48 K J -2.4594 Soluble
49 G J -1.7460 Soluble
50 L J 0.0000 Buried
51 E J -1.6192 Soluble
52 W J 0.0000 Buried
53 V J 0.0000 Buried
54 T J 0.0000 Buried
55 F J 0.0906 Aggregation-prone
56 I J 0.0000 Buried
57 S J -0.8349 Soluble
58 Y J -0.3974 Soluble
59 D J -2.1042 Soluble
62 G J -1.9781 Soluble
63 N J -2.5175 Soluble
64 N J -2.1949 Soluble
65 K J -1.2840 Soluble
66 Y J -0.0007 Soluble
67 Y J -0.3857 Soluble
68 A J -1.0356 Soluble
69 D J -2.0876 Soluble
70 S J -1.5611 Soluble
71 V J 0.0000 Buried
72 K J -2.2710 Soluble
74 G J -1.4511 Soluble
75 R J 0.0000 Buried
76 F J 0.0000 Buried
77 T J -0.9309 Soluble
78 I J 0.0000 Buried
79 S J -0.6363 Soluble
80 R J -1.2032 Soluble
81 D J -1.5683 Soluble
82 N J -1.7369 Soluble
83 S J -1.5609 Soluble
84 K J -2.2727 Soluble
85 N J -1.6754 Soluble
86 T J -0.8662 Soluble
87 L J 0.0000 Buried
88 Y J -0.6348 Soluble
89 L J 0.0000 Buried
90 Q J -1.5141 Soluble
91 M J 0.0000 Buried
92 N J -1.9281 Soluble
93 S J -1.8187 Soluble
94 L J 0.0000 Buried
95 R J -2.7137 Soluble
96 A J -1.6065 Soluble
97 E J -1.9206 Soluble
98 D J 0.0000 Buried
99 T J -0.3705 Soluble
100 A J 0.0000 Buried
101 I J 0.7966 Aggregation-prone
102 Y J 0.0000 Buried
103 Y J 0.0000 Buried
104 C J 0.0000 Buried
105 A J 0.0000 Buried
106 R J 0.0000 Buried
107 T J 0.6320 Aggregation-prone
108 G J 0.0000 Buried
109 W J 1.8624 Aggregation-prone
110 L J 2.1737 Aggregation-prone
113 G J 1.1307 Aggregation-prone
114 P J 0.0000 Buried
115 F J 0.0000 Buried
116 D J 0.2187 Aggregation-prone
117 Y J 0.3336 Aggregation-prone
118 W J 0.0016 Aggregation-prone
119 G J 0.0000 Buried
120 Q J -1.1325 Soluble
121 G J -0.1409 Soluble
122 T J 0.4239 Aggregation-prone
123 L J 1.2507 Aggregation-prone
124 V J 0.0000 Buried
125 T J 0.3444 Aggregation-prone
126 V J 0.0000 Buried
127 S J -0.4680 Soluble
1 E K -1.4515 Soluble
2 I K -0.1200 Soluble
3 V K 0.8174 Aggregation-prone
4 L K 0.0000 Buried
5 T K -0.7358 Soluble
6 Q K 0.0000 Buried
7 S K -0.9448 Soluble
8 P K -0.5589 Soluble
9 G K -0.9710 Soluble
10 T K -0.8228 Soluble
11 L K -0.4447 Soluble
12 S K -0.8485 Soluble
13 L K -1.0274 Soluble
14 S K -1.8909 Soluble
15 P K -2.1353 Soluble
16 G K -2.3825 Soluble
17 E K -2.8669 Soluble
18 R K -3.0383 Soluble
19 A K 0.0000 Buried
20 T K -0.6689 Soluble
21 L K 0.0000 Buried
22 S K -0.8310 Soluble
23 C K 0.0000 Buried
24 R K -2.2767 Soluble
25 A K 0.0000 Buried
26 S K -0.8516 Soluble
27 Q K -1.5529 Soluble
28 S K -1.2906 Soluble
29 V K 0.0000 Buried
30 G K -0.6054 Soluble
36 S K -0.1343 Soluble
37 S K 0.4389 Aggregation-prone
38 Y K 0.7216 Aggregation-prone
39 L K 0.0000 Buried
40 A K 0.0000 Buried
41 W K 0.0000 Buried
42 Y K 0.0000 Buried
43 Q K 0.0000 Buried
44 Q K 0.0000 Buried
45 K K -1.4359 Soluble
46 P K -0.9045 Soluble
47 G K -1.4434 Soluble
48 Q K -2.0766 Soluble
49 A K -1.2913 Soluble
50 P K 0.0000 Buried
51 R K -1.2329 Soluble
52 L K 0.0000 Buried
53 L K 0.0000 Buried
54 I K 0.0000 Buried
55 Y K 0.6967 Aggregation-prone
56 G K 0.7209 Aggregation-prone
57 A K 0.0000 Buried
65 F K 1.3201 Aggregation-prone
66 S K 0.2280 Aggregation-prone
67 R K -0.9008 Soluble
68 A K 0.0000 Buried
69 T K -0.5429 Soluble
70 G K -0.7761 Soluble
71 I K -0.8809 Soluble
72 P K -1.1720 Soluble
74 D K -2.3332 Soluble
75 R K -2.0066 Soluble
76 F K 0.0000 Buried
77 S K -0.4532 Soluble
78 G K 0.3104 Aggregation-prone
79 S K 0.0801 Aggregation-prone
80 G K -0.5978 Soluble
83 S K -0.9810 Soluble
84 G K -1.1967 Soluble
85 T K -1.6733 Soluble
86 D K -1.9948 Soluble
87 F K 0.0000 Buried
88 T K -0.4797 Soluble
89 L K 0.0000 Buried
90 T K -0.8001 Soluble
91 I K 0.0000 Buried
92 S K -2.5492 Soluble
93 R K -3.4557 Soluble
94 L K 0.0000 Buried
95 E K -2.3149 Soluble
96 P K -1.9408 Soluble
97 E K -2.0207 Soluble
98 D K 0.0000 Buried
99 F K -0.6165 Soluble
100 A K 0.0000 Buried
101 V K -0.5046 Soluble
102 Y K 0.0000 Buried
103 Y K 0.0000 Buried
104 C K 0.0000 Buried
105 Q K 0.0000 Buried
106 Q K 0.0000 Buried
107 Y K 0.0000 Buried
108 G K -0.1947 Soluble
109 S K -0.4694 Soluble
114 S K -0.3569 Soluble
115 P K -0.5487 Soluble
116 W K -0.0821 Soluble
117 T K -0.1831 Soluble
118 F K -0.0688 Soluble
119 G K 0.0000 Buried
120 Q K -1.6412 Soluble
121 G K 0.0000 Buried
122 T K 0.0000 Buried
123 K K -1.3532 Soluble
124 V K 0.0000 Buried
125 E K -1.1368 Soluble
126 I K -1.4993 Soluble
127 K K -1.8021 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.592 4.3206 CSV PDB
4.5 -0.6271 4.3112 CSV PDB
5.0 -0.6704 4.3011 CSV PDB
5.5 -0.7145 4.2907 CSV PDB
6.0 -0.7505 4.2802 CSV PDB
6.5 -0.7718 4.2697 CSV PDB
7.0 -0.7772 4.2593 CSV PDB
7.5 -0.7708 4.2492 CSV PDB
8.0 -0.7574 4.2398 CSV PDB
8.5 -0.7387 4.2321 CSV PDB
9.0 -0.7151 4.2272 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH