Diridavumab / 8f38

A4DAB087_8f38_D_G | Source PDB: 8f38 | Chains: D, G | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.4749
Max Score
3.0226
Min Score
-2.9702
Total Score
-107.8
Score CDR
-0.1688
Score non-CDR
-0.5681

Calculation Parameters

Chain Sequence(s) VQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRRPTAYVVFGGGTKLTVL input.pdb
Selected Chain(s) D (Heavy), G (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.9702
Maximum Score 3.0226
Average Score -0.4749
Total Score -107.8012

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V D 1.0758 Aggregation-prone
3 Q D -0.3952 Soluble
4 L D 0.0000 Buried
5 V D 0.2211 Aggregation-prone
6 E D -0.2639 Soluble
7 S D -0.5287 Soluble
8 G D -0.5431 Soluble
9 A D -0.1462 Soluble
11 E D 0.0289 Aggregation-prone
12 V D 1.1234 Aggregation-prone
13 K D -0.6676 Soluble
14 K D -1.9542 Soluble
15 P D -2.1951 Soluble
16 G D -1.6219 Soluble
17 S D -1.2886 Soluble
18 S D -1.2833 Soluble
19 V D 0.0000 Buried
20 K D -1.9122 Soluble
21 V D 0.0000 Buried
22 S D -0.4602 Soluble
23 C D 0.0000 Buried
24 K D -0.7093 Soluble
25 A D -0.2058 Soluble
26 S D -0.4170 Soluble
27 G D -0.4529 Soluble
28 G D -0.1575 Soluble
29 P D 0.3619 Aggregation-prone
30 F D 1.6832 Aggregation-prone
35 R D 0.6438 Aggregation-prone
36 S D 0.7786 Aggregation-prone
37 Y D 0.8180 Aggregation-prone
38 A D 0.0000 Buried
39 I D 0.0000 Buried
40 S D 0.0000 Buried
41 W D 0.0000 Buried
42 V D 0.0000 Buried
43 R D 0.0000 Buried
44 Q D 0.0000 Buried
45 A D -0.9867 Soluble
46 P D -0.8479 Soluble
47 G D -1.2090 Soluble
48 Q D -1.7483 Soluble
49 G D -1.1930 Soluble
50 P D 0.0000 Buried
51 E D -0.9644 Soluble
52 W D 0.0000 Buried
53 M D 0.0000 Buried
54 G D 0.0000 Buried
55 G D 0.0000 Buried
56 I D 0.0000 Buried
57 I D 0.0000 Buried
58 P D 0.0000 Buried
59 I D 3.0226 Aggregation-prone
62 F D 2.7997 Aggregation-prone
63 G D 1.0315 Aggregation-prone
64 T D 0.3833 Aggregation-prone
65 T D -0.1263 Soluble
66 K D -0.5535 Soluble
67 Y D -0.7527 Soluble
68 A D 0.0000 Buried
69 P D -1.5599 Soluble
70 K D -2.3591 Soluble
71 F D 0.0000 Buried
72 Q D -2.2068 Soluble
74 G D -1.6204 Soluble
75 R D -1.5915 Soluble
76 V D 0.0000 Buried
77 T D -0.8740 Soluble
78 I D 0.0000 Buried
79 T D -0.4559 Soluble
80 A D -0.6013 Soluble
81 D D -0.8871 Soluble
82 D D -0.1534 Soluble
83 F D 1.3574 Aggregation-prone
84 A D 0.3171 Aggregation-prone
85 G D -0.2670 Soluble
86 T D 0.0000 Buried
87 V D 0.0000 Buried
88 Y D -0.4838 Soluble
89 M D 0.0000 Buried
90 E D -1.5277 Soluble
91 L D 0.0000 Buried
92 S D -1.2690 Soluble
93 S D -1.3029 Soluble
94 L D 0.0000 Buried
95 R D -2.9702 Soluble
96 S D -2.1325 Soluble
97 E D -2.4340 Soluble
98 D D 0.0000 Buried
99 T D -0.6112 Soluble
100 A D 0.0000 Buried
101 M D -0.0202 Soluble
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 A D 0.0000 Buried
106 K D 0.1625 Aggregation-prone
107 H D 0.0000 Buried
108 M D 0.5024 Aggregation-prone
109 G D 0.2725 Aggregation-prone
110 Y D 1.1288 Aggregation-prone
111 Q D -0.3847 Soluble
112A V D 0.0000 Buried
112 R D -0.3892 Soluble
113 E D 0.0000 Buried
114 T D -0.1905 Soluble
115 M D 0.0000 Buried
116 D D -0.5406 Soluble
117 V D 0.0649 Aggregation-prone
118 W D -0.3012 Soluble
119 G D 0.0000 Buried
120 K D -1.6058 Soluble
121 G D -0.7098 Soluble
122 T D 0.0000 Buried
123 T D 0.0939 Aggregation-prone
124 V D 0.0000 Buried
125 T D -0.0542 Soluble
126 V D -0.5566 Soluble
3 V G 1.6255 Aggregation-prone
4 L G 0.0000 Buried
5 T G -0.0226 Soluble
6 Q G -0.3829 Soluble
7 P G -0.5739 Soluble
8 P G -0.7626 Soluble
9 S G -0.7564 Soluble
11 V G -0.2219 Soluble
12 S G -0.0798 Soluble
13 A G -0.2080 Soluble
14 A G -0.3288 Soluble
15 P G -1.0218 Soluble
16 G G -1.7407 Soluble
17 Q G -2.2371 Soluble
18 K G -2.4085 Soluble
19 V G 0.0000 Buried
20 T G -0.5086 Soluble
21 I G 0.0000 Buried
22 S G -0.3803 Soluble
23 C G 0.0000 Buried
24 S G -0.2892 Soluble
25 G G -0.0216 Soluble
26 S G -0.3946 Soluble
27 S G -0.9257 Soluble
28 S G -1.1779 Soluble
29 N G 0.0000 Buried
30 I G 0.0000 Buried
35 G G -1.1698 Soluble
36 N G -1.5575 Soluble
37 D G -0.6453 Soluble
38 Y G 0.2193 Aggregation-prone
39 V G 0.0000 Buried
40 S G 0.0000 Buried
41 W G 0.0000 Buried
42 Y G 0.0000 Buried
43 Q G 0.0000 Buried
44 Q G -0.7345 Soluble
45 L G -0.4508 Soluble
46 P G -0.5135 Soluble
47 G G -0.7282 Soluble
48 T G -0.7470 Soluble
49 A G -0.7351 Soluble
50 P G 0.0000 Buried
51 K G -1.1189 Soluble
52 L G 0.0000 Buried
53 L G 0.0000 Buried
54 I G 0.0000 Buried
55 Y G -1.3064 Soluble
56 D G -1.7123 Soluble
57 N G -1.6226 Soluble
65 N G -2.5758 Soluble
66 K G -2.7969 Soluble
67 R G -2.3294 Soluble
68 P G -0.9887 Soluble
69 S G -0.7281 Soluble
70 G G -0.8007 Soluble
71 I G -0.9102 Soluble
72 P G -1.2684 Soluble
74 D G -2.1796 Soluble
75 R G -1.5351 Soluble
76 F G 0.0000 Buried
77 S G -1.4598 Soluble
78 G G -1.3794 Soluble
79 S G -1.3664 Soluble
80 K G -1.0864 Soluble
83 S G -0.8633 Soluble
84 G G -1.0582 Soluble
85 T G -0.9450 Soluble
86 S G -0.7604 Soluble
87 A G 0.0000 Buried
88 T G -0.5079 Soluble
89 L G 0.0000 Buried
90 G G -0.6923 Soluble
91 I G 0.0000 Buried
92 T G -1.7666 Soluble
93 G G -1.4526 Soluble
94 L G 0.0000 Buried
95 Q G -1.6828 Soluble
96 T G -0.9516 Soluble
97 G G -1.1410 Soluble
98 D G 0.0000 Buried
99 E G -1.4565 Soluble
100 A G 0.0000 Buried
101 N G -0.9455 Soluble
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 A G 0.0000 Buried
106 T G 0.0000 Buried
107 W G 0.0000 Buried
108 D G -0.9859 Soluble
109 R G -2.2807 Soluble
110 R G -2.5301 Soluble
112 P G -1.4410 Soluble
113 T G -1.0272 Soluble
114 A G -1.1004 Soluble
115 Y G -0.2769 Soluble
116 V G 0.0000 Buried
117 V G 0.4492 Aggregation-prone
118 F G 0.3241 Aggregation-prone
119 G G 0.0612 Aggregation-prone
120 G G -0.4917 Soluble
121 G G -0.9559 Soluble
122 T G 0.0000 Buried
123 K G -1.5659 Soluble
124 L G 0.0000 Buried
125 T G -0.2952 Soluble
126 V G 0.0591 Aggregation-prone
127 L G 1.2984 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3295 5.787 CSV PDB
4.5 -0.3574 5.787 CSV PDB
5.0 -0.3885 5.787 CSV PDB
5.5 -0.4172 5.787 CSV PDB
6.0 -0.4361 5.787 CSV PDB
6.5 -0.4384 5.787 CSV PDB
7.0 -0.4232 5.787 CSV PDB
7.5 -0.3963 5.787 CSV PDB
8.0 -0.3629 5.7869 CSV PDB
8.5 -0.3242 5.7869 CSV PDB
9.0 -0.2802 5.7866 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH